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MeSH Review

Adenoma, Oxyphilic

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Disease relevance of Adenoma, Oxyphilic

  • Three families classified with familial renal oncocytoma were identified with BHD mutations, which represents the first disease gene associated with this rare form of renal neoplasm [1].
  • Thus, we conclude that MN/CA9 protein expression could serve as a valuable adjunct to the cytological and histological diagnosis of benign renal cysts versus cystic RCC, adenoma versus RCC, and oncocytoma versus granular cell RCC [2].
  • Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma [3].
  • There were no differences in Rex-1 mRNA or protein expression among the various histologic subtypes of renal tumors (clear cell carcinoma, papillary carcinoma, chromophobe carcinoma and oncocytoma) [4].
  • Based on the light microscopic appearance and ultrastructural and enzyme histochemical findings, the nasal tumor was primarily diagnosed as an oncocytoma, but due to the finding of neurosecretory granules and positivity for NSE in tumor cells, we believe it should be regarded as an oncocytic carcinoid [5].

High impact information on Adenoma, Oxyphilic

  • Detailed histopathology was available for 59 of the tumours investigated: 18 of 43 (42%) RCC with a clear cell appearance had a somatic VHL gene mutation but none of 16 non-clear cell RCC (eight chromophilic, three chromophobe and five oncocytoma) (chi2 = 7.77, P < 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)[6]
  • In adult p53-null mice, wt1-heterozygosity (wt1het) predisposes to an earlier onset of lymphomagenesis and the development of kidney abnormalities resembling oncocytoma in humans. wt1-heterozygosity alone predisposes to the development of glomerular sclerosis [7].
  • PVALB was highest in chromophobe RCC, variable in oncocytoma, and low in clear cell and papillary types [8].
  • RESULTS: CA9 expression was highest in clear cell carcinoma and lowest in chromophobe RCC and in oncocytoma [8].
  • AMACR expression was highest in papillary RCC, and CLCNKB was highest in chromophobe RCC/oncocytoma [8].

Chemical compound and disease context of Adenoma, Oxyphilic

  • In the formalin-fixed group, the molecular criteria accurately classified the cases into 15 clear cell, 16 papillary, and 32 in the chromophobe/oncocytoma group but could only separate some, but not all, oncocytomas from chromophobe RCC [8].
  • Iodine-131 therapy for parotid oncocytoma [9].
  • Since other tumors were found to be linked to mitochondrial deficiencies like genetic alterations of fumarate hydratase or succinate dehydrogenase, oncocytoma could be the third type of benign tumor associated with impairment of mitochondrial ATP production in an oxidative, quiescent tissue [10].
  • The technical results of 259 nephron sparing operations for renal cell carcinoma or renal oncocytoma were reviewed [11].
  • Finally, it should be determined whether KIT plays a role in the tumorigenesis of ChRCC and oncocytoma and whether targeted therapy with STI-571, an inhibitor of KIT, could be effective in exceptional cases of ChRCC with metastatic extension or recurrence [12].

Biological context of Adenoma, Oxyphilic


Anatomical context of Adenoma, Oxyphilic


Gene context of Adenoma, Oxyphilic

  • We conclude that overexpression of the PRC pathway is responsible for mitochondrial proliferation in the context of thyroid oncocytoma [18].
  • Semiquantitative assessment of immunohistochemical staining demonstrated significant increases in epithelial associated IGF-I and IGFBP-3 in clear cell RCC, increased IGFBP-5 protein in papillary RCC and no significant changes in IGF/IGFBP protein expression in oncocytoma [21].
  • Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus [16].
  • The results suggest an association between loss of caveolin expression among malignant renal tumors that might be useful in distinguishing oncocytoma from malignant renal tumors and possibly implicates this peptide in their pathogenesis [22].
  • An immunoblot analysis confirmed the presence of paxillin in healthy kidney, chromophobe RCC, and oncocytoma [23].

Analytical, diagnostic and therapeutic context of Adenoma, Oxyphilic


Gene context of Adenoma, Oxyphilic


  1. Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. Schmidt, L.S., Nickerson, M.L., Warren, M.B., Glenn, G.M., Toro, J.R., Merino, M.J., Turner, M.L., Choyke, P.L., Sharma, N., Peterson, J., Morrison, P., Maher, E.R., Walther, M.M., Zbar, B., Linehan, W.M. Am. J. Hum. Genet. (2005) [Pubmed]
  2. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Liao, S.Y., Aurelio, O.N., Jan, K., Zavada, J., Stanbridge, E.J. Cancer Res. (1997) [Pubmed]
  3. Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma. Nagy, A., Zoubakov, D., Stupar, Z., Kovacs, G. Int. J. Cancer (2004) [Pubmed]
  4. Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma. Raman, J.D., Mongan, N.P., Liu, L., Tickoo, S.K., Nanus, D.M., Scherr, D.S., Gudas, L.J. Carcinogenesis (2006) [Pubmed]
  5. Oncocytic carcinoid of the nasal cavity and carcinoid of the lung in a child. Siwersson, U., Kindblom, L.G. Pathol. Res. Pract. (1984) [Pubmed]
  6. Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma. Foster, K., Prowse, A., van den Berg, A., Fleming, S., Hulsbeek, M.M., Crossey, P.A., Richards, F.M., Cairns, P., Affara, N.A., Ferguson-Smith, M.A. Hum. Mol. Genet. (1994) [Pubmed]
  7. Genetic interactions between the Wilms' tumor 1 gene and the p53 gene. Menke, A.L., Clarke, A.R., Leitch, A., Ijpenberg, A., Williamson, K.A., Spraggon, L., Harrison, D.J., Hastie, N.D. Cancer Res. (2002) [Pubmed]
  8. Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma. Chen, Y.T., Tu, J.J., Kao, J., Zhou, X.K., Mazumdar, M. Clin. Cancer Res. (2005) [Pubmed]
  9. Iodine-131 therapy for parotid oncocytoma. Kosuda, S., Ishikawa, M., Tamura, K., Mukai, M., Kubo, A., Hashimoto, S. J. Nucl. Med. (1988) [Pubmed]
  10. Mitochondrial complex I is deficient in renal oncocytomas. Simonnet, H., Demont, J., Pfeiffer, K., Guenaneche, L., Bouvier, R., Brandt, U., Schagger, H., Godinot, C. Carcinogenesis (2003) [Pubmed]
  11. Complications of nephron sparing surgery for renal tumors. Campbell, S.C., Novick, A.C., Streem, S.B., Klein, E., Licht, M. J. Urol. (1994) [Pubmed]
  12. KIT expression in chromophobe renal cell carcinoma: comparative immunohistochemical analysis of KIT expression in different renal cell neoplasms. Petit, A., Castillo, M., Santos, M., Mellado, B., Alcover, J.B., Mallofré, C. Am. J. Surg. Pathol. (2004) [Pubmed]
  13. Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis. Gonzalgo, M.L., Yegnasubramanian, S., Yan, G., Rogers, C.G., Nicol, T.L., Nelson, W.G., Pavlovich, C.P. Clin. Cancer Res. (2004) [Pubmed]
  14. The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma. Rampino, T., Gregorini, M., Soccio, G., Maggio, M., Rosso, R., Malvezzi, P., Collesi, C., Dal Canton, A. Am. J. Surg. Pathol. (2003) [Pubmed]
  15. Benign and malignant oncocytoma of the salivary glands with an immunohistochemical evaluation of Ki-67. Ito, K., Tsukuda, M., Kawabe, R., Nakagawa, C., Matsushita, K., Kubota, A., Furukawa, M., Kameda, Y., Ito, T. ORL J. Otorhinolaryngol. Relat. Spec. (2000) [Pubmed]
  16. Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus. Kollert-Jöns, A., Wagner, S., Hübner, S., Appelhans, H., Drenckhahn, D. Am. J. Physiol. (1993) [Pubmed]
  17. Mitochondrial adenosine triphosphatase in the oxyphil cells of a renal oncocytoma. Hunter, V.R., Pauly, D.F., Wolkowicz, P.E., McMillin, J.B., Beckner, M.E. Hum. Pathol. (1990) [Pubmed]
  18. PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma. Savagner, F., Mirebeau, D., Jacques, C., Guyetant, S., Morgan, C., Franc, B., Reynier, P., Malthièry, Y. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  19. Parotid oncocytoma in the Birt-Hogg-Dubé syndrome. Liu, V., Kwan, T., Page, E.H. J. Am. Acad. Dermatol. (2000) [Pubmed]
  20. Renal oncocytoma mimicking hemorrhagic renal cyst. Sekido, N., Kawai, K., Takeshima, H., Akaza, H., Koiso, K. International journal of urology : official journal of the Japanese Urological Association. (1995) [Pubmed]
  21. Altered messenger RNA and protein expressions for insulin-like growth factor family members in clear cell and papillary renal cell carcinomas. Cheung, C., Vesey, D., Cotterill, A., Douglas, M., Gobe, G., Nicol, D., Johnson, D. International journal of urology : official journal of the Japanese Urological Association. (2005) [Pubmed]
  22. Caveolin expression in adult renal tumors. Carrion, R., Morgan, B.E., Tannenbaum, M., Salup, R., Morgan, M.B. Urol. Oncol. (2003) [Pubmed]
  23. Paxillin: application of immunohistochemistry to the diagnosis of chromophobe renal cell carcinoma and oncocytoma. Kuroda, N., Guo, L., Toi, M., Naruse, K., Miyazaki, E., Hayashi, Y., Yoshikawa, C., Ashida, S., Shuin, T., Enzan, H. Appl. Immunohistochem. Mol. Morphol. (2001) [Pubmed]
  24. Partial nephrectomy for a renal oncocytoma associated with tuberous sclerosis. Srinivas, V., Herr, H.W., Hajdu, E.O. J. Urol. (1985) [Pubmed]
  25. Expression of CD9/motility-related protein 1 (MRP-1) in renal parenchymal neoplasms: consistent expression in papillary and chromophobe renal cell carcinomas. Kuroda, N., Inoue, K., Guo, L., Miyazaki, E., Hayashi, Y., Naruse, K., Toi, M., Hiroi, M., Shuin, T., Enzan, H. Hum. Pathol. (2001) [Pubmed]
  26. Magnetic resonance spectroscopy and chromatographic methods identify altered lipid composition in human renal neoplasms. Tosi, M.R., Rodriguez-Estrada, M.T., Lercker, G., Poerio, A., Trinchero, A., Reggiani, A., Tugnoli, V. Int. J. Mol. Med. (2004) [Pubmed]
  27. Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. Salido, M., Lloreta, J., Melero, C., García, M., Placer, J., Espinet, B., Villa, O., Bielsa, O., Gelabert-Mas, A., Serrano, S., Solé, F. Cancer Genet. Cytogenet. (2005) [Pubmed]
  28. FDG PET-negative liver metastases of a malignant melanoma and FDG PET-positive hurthle cell tumor of the thyroid. Wiesner, W., Engel, H., von Schulthess, G.K., Krestin, G.P., Bicik, I. European radiology. (1999) [Pubmed]
  29. Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Rohan, S., Tu, J.J., Kao, J., Mukherjee, P., Campagne, F., Zhou, X.K., Hyjek, E., Alonso, M.A., Chen, Y.T. Clin. Cancer Res. (2006) [Pubmed]
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