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Gene Review

PPFIA1  -  protein tyrosine phosphatase, receptor...

Homo sapiens

Synonyms: LAR-interacting protein 1, LIP-1, LIP.1, LIP1, LIPRIN, ...
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Disease relevance of PPFIA1


High impact information on PPFIA1


Biological context of PPFIA1


Anatomical context of PPFIA1


Associations of PPFIA1 with chemical compounds

  • Here, we identified liprin alpha1/PPFIA1, a cytoplasmic protein necessary for focal adhesion formation and axon guidance, as a novel interacting protein with ING4 [2].
  • LIP1 was also compared with Lipozyme RM IM as biocatalysts [12].

Physical interactions of PPFIA1

  • Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation [7].
  • GIT1 is enriched in PSD fractions and forms a complex with liprin-alpha, GRIP, and AMPA receptors in brain [13].
  • Here we report that liprin-alpha directly interacts with the ERC (ELKS-Rab6-interacting protein-CAST) family of proteins, members of which are known to bind RIMs, the active zone proteins that regulate neurotransmitter release [14].
  • To better understand the structural basis of peptide recognition by a class II PDZ domain and PDZ-mediated multimerization, we determined the crystal structures of the GRIP1 PDZ6 domain alone and in complex with a synthetic C-terminal octapeptide of human liprin-alpha at resolutions of 1.5 and 1.8 A, respectively [15].

Regulatory relationships of PPFIA1

  • Taken together, our results suggest that liprin autophosphorylation regulates its association with LAR [7].

Other interactions of PPFIA1

  • This is the first report on comprehensive characterization of PPFIA4 belonging to the PPFIA family of kinesin-cargo linkers [16].
  • Expression of dominant-negative constructs interfering with the GIT1-liprin-alpha interaction leads to a selective and marked reduction in the dendritic and surface clustering of AMPA receptors in cultured neurons [13].
  • Liprin-alpha/SYD-2 is a family of multidomain proteins with four known isoforms [14].
  • Recently, liprin-alpha proteins, which define active zone size and morphology, were found to associate with MALS/CASK, suggesting that this complex links the presynaptic release machinery to the active zone, thereby regulating neurotransmitter release [4].


  1. Liprin-alpha2 gene, protein tyrosine phosphatase LAR interacting protein related gene, is downregulated by androgens in the human prostate cancer cell line LNCaP. Fujinami, K., Uemura, H., Ishiguro, H., Kubota, Y. Int. J. Mol. Med. (2002) [Pubmed]
  2. Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. Shen, J.C., Unoki, M., Ythier, D., Duperray, A., Varticovski, L., Kumamoto, K., Pedeux, R., Harris, C.C. Cancer Res. (2007) [Pubmed]
  3. Cloning, sequence and structural features of a lipase from the antarctic facultative psychrophile Psychrobacter immobilis B10. Arpigny, J.L., Feller, G., Gerday, C. Biochim. Biophys. Acta (1993) [Pubmed]
  4. Synaptic transmission regulated by a presynaptic MALS/Liprin-alpha protein complex. Olsen, O., Moore, K.A., Nicoll, R.A., Bredt, D.S. Curr. Opin. Cell Biol. (2006) [Pubmed]
  5. LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses. Dunah, A.W., Hueske, E., Wyszynski, M., Hoogenraad, C.C., Jaworski, J., Pak, D.T., Simonetta, A., Liu, G., Sheng, M. Nat. Neurosci. (2005) [Pubmed]
  6. The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. Serra-Pagès, C., Kedersha, N.L., Fazikas, L., Medley, Q., Debant, A., Streuli, M. EMBO J. (1995) [Pubmed]
  7. Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation. Serra-Pagès, C., Streuli, M., Medley, Q.G. Biochemistry (2005) [Pubmed]
  8. Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Zhang, Z., DuBois, R.N. Oncogene (2001) [Pubmed]
  9. The dark-adaptation response of the de-etiolated pea mutant lip1 is modulated by external signals and endogenous programs. Frances, S., Thompson, W.F. Plant Physiol. (1997) [Pubmed]
  10. Liprin-alpha has LAR-independent functions in R7 photoreceptor axon targeting. Hofmeyer, K., Maurel-Zaffran, C., Sink, H., Treisman, J.E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  11. The distribution of protochlorophyllide and chlorophyll within seedlings of the lip1 mutant of Pea. Seyedi, M., Timko, M.P., Sundqvist, C. Plant Cell Physiol. (2001) [Pubmed]
  12. Candida rugosa lipase LIP1-catalyzed transesterification to produce human milk fat substitute. Srivastava, A., Akoh, C.C., Chang, S.W., Lee, G.C., Shaw, J.F. J. Agric. Food Chem. (2006) [Pubmed]
  13. Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. Ko, J., Kim, S., Valtschanoff, J.G., Shin, H., Lee, J.R., Sheng, M., Premont, R.T., Weinberg, R.J., Kim, E. J. Neurosci. (2003) [Pubmed]
  14. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. Ko, J., Na, M., Kim, S., Lee, J.R., Kim, E. J. Biol. Chem. (2003) [Pubmed]
  15. Crystal structure of GRIP1 PDZ6-peptide complex reveals the structural basis for class II PDZ target recognition and PDZ domain-mediated multimerization. Im, Y.J., Park, S.H., Rho, S.H., Lee, J.H., Kang, G.B., Sheng, M., Kim, E., Eom, S.H. J. Biol. Chem. (2003) [Pubmed]
  16. Identification and characterization of human PPFIA4 gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
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