Disease relevance of Legg-Perthes Disease

• Protein C and S deficiency, thrombophilia, and hypofibrinolysis: pathophysiologic causes of Legg-Perthes disease [1].
• We hypothesized that the bisphosphonate zoledronic acid (ZA) could improve femoral head sphericity in Perthes disease by changing the balance between bone resorption and new bone formation [2].
• Compression fracture of the secondary centers of ossification is an important factor in the pathogenesis of Perthes' disease and osteochondrosis dissecans [3].
• Factors relating to hip joint arthritis following three childhood diseases--juvenile rheumatoid arthritis, Perthes disease, and postreduction avascular necrosis in congenital hip dislocation [4].
• The causes of the overgrowth were Perthes disease, avascular necrosis after treatment of developmental dysplasia of the hip, septic arthritis and rheumatoid arthritis [5].

High impact information on Legg-Perthes Disease

• In eight patients with Legg-Perthes disease, we assessed the etiologic roles of thrombophilia caused by protein C and protein S deficiency and hypofibrinolysis mediated by low levels of tissue plasminogen activator activity [1].
• Assays for the detection of factor-V Leiden mutation and the plasma concentrations of protein C, protein S, antithrombin III, and lipoprotein (a) were performed on plasma samples from children with Legg-Perthes disease, and the results were compared with those for pooled plasma from normal controls [6].
• We have cloned the canine protein C gene to investigate whether Morbus Perthes disease in dogs is also caused by mutations within this gene [7].
• Thirty-two patients in whom Legg-Perthes disease apparently involved only one hip were examined with venography, measurement of intraosseous and intra-articular pressures, arthrography, and dynamic triphasic bone-imaging with 99mTc methylene diphosphonate [8].
• Three-dimensional CT and MRI were used to analyse the detailed morphology of the acetabulum with special reference to its inner surface, in 16 patients with Perthes' disease and a bicompartmental acetabulum.The bicompartmental appearance was seen on the coronal plane image through the acetabular fossa [9].

Chemical compound and disease context of Legg-Perthes Disease

• Zoledronic acid improves femoral head sphericity in a rat model of perthes disease [2].
• Low blood manganese levels in Liverpool children with Perthes' disease [10].
• The plasma-IGF I levels, measured by radioimmunoassay after acid ethanol extraction, were reduced in affected children during the first 2 years after the diagnosis of Perthes' disease [11].
• We studied Insulin-like Growth Factor I (IGF I) plasma levels, standing height, and weight in 59 consecutive children with Perthes' disease and 59 matched controls [11].
• Serial quantitative scintigraphic studies using 99mTc-methylene diphosphonate were performed on 25 hips with Legg-Perthes' disease to evaluate changes in local blood flow of the femoral head after subtrochanteric varizational and/or derotational osteotomy [12].

Biological context of Legg-Perthes Disease

• Eight of 64 children with Legg-Perthes disease had a low activated protein C ratio and the mutant Factor V gene (7 heterozygotes, 1 homozygote) versus 1 of 101 normal pediatric controls [13].
• Certain epidemiologic characteristics of Perthes' disease (sex ratio, socioeconomic status, geographic location, and associated congenital anomalies) are also similar to those of ADHD, suggesting a correlation between the two disorders [14].

Anatomical context of Legg-Perthes Disease

• Mutations in the human protein C gene have been linked to some cases of Morbus Perthes disease, a thrombophilic condition that results in aseptic necrosis of the femur head and neck [7].

Gene context of Legg-Perthes Disease

• Plasma levels of insulin-like growth factor binding protein-3 (IGFBP-3) were measured in 55 children with Perthes' disease and 55 age- and sex-matched controls [15].
• Normal plasma levels of IGF binding protein in Perthes' disease. Follow-up of previous report [15].
• Serum somatomedin A in Perthes' disease [16].
• The most severe forms of Perthes' disease associated with the homozygous Factor V Leiden mutation [17].
• Normal somatomedin-C activity measured by radioimmunoassay in Perthes' disease [18].

Analytical, diagnostic and therapeutic context of Legg-Perthes Disease

• Serum somatomedin A, determined by radioreceptor assay in 47 children with Perthes' disease, was significantly reduced as compared to normal children of the same age [16].
• The purpose of this study was to review radiological changes in LP grade in older patients with Perthes disease during 20 months of treatment with skin traction and ROM exercises [19].

References