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Gbx1  -  gastrulation brain homeobox 1

Mus musculus

Synonyms: Gastrulation and brain-specific homeobox protein 1, Gbx-1, Homeobox protein GBX-1
 
 
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High impact information on Gbx1

  • Although cholinergic neurons are not formed, initial steps in their specification appear to be preserved, as indicated by a presence of cells expressing a truncated Lhx8 mRNA and mRNA of the homeobox gene Gbx1 [1].
  • Immunohistological analyses revealed that Gbx1 identifies a distinct population of late-born, Lhx1/5(+), Pax2(+) neurons [2].
  • Expression of Gbx1 in the dorsal spinal cord depends on Lbx1 function [2].
  • The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord [2].
  • Therefore, the only regions of potential genetic redundancy are where Gbx1 and 2 are normally coexpressed: the primitive streak, regions of the ventricular zone of the neural tube and the medial ganglionic eminence [3].
 

Anatomical context of Gbx1

  • Gbx1 is expressed first during gastrulation and later in a dynamic pattern in the central nervous system, including rhombomeres 3 and 5, optic vesicles, and the medial ganglionic eminence [3].

References

  1. The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Zhao, Y., Marín, O., Hermesz, E., Powell, A., Flames, N., Palkovits, M., Rubenstein, J.L., Westphal, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. The homeodomain transcription factor Gbx1 identifies a subpopulation of late-born GABAergic interneurons in the developing dorsal spinal cord. John, A., Wildner, H., Britsch, S. Dev. Dyn. (2005) [Pubmed]
  3. Cloning and embryonic expression analysis of the mouse Gbx1 gene. Waters, S.T., Wilson, C.P., Lewandoski, M. Gene Expr. Patterns (2003) [Pubmed]
 
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