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Gene Review

GBX1  -  gastrulation brain homeobox 1

Homo sapiens

Synonyms: Gastrulation and brain-specific homeobox protein 1, Homeobox protein GBX-1
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Disease relevance of GBX1

  • In the present studies, specific primer sets were designed for reverse transcription-PCR detection of the expression of GBX1 versus GBX2 in human prostate cancer [1].

High impact information on GBX1

  • Previously, we have demonstrated that GBX genes, a homeobox-containing human family of DNA-binding transcription factors consisting of GBX1 and GBX2, are overexpressed in a panel of human prostatic cancer cell lines (ie., TSU-pr1, PC3, DU145, and LNCaP) compared to normal prostate [1].
  • GBX1 and EN-2 have been mapped to chromosome 7q36 [2].
  • Northern hybridization of mRNA for various kinds of hematopoietic cell showed that the newly identified GBX1 gene is expressed in K562 cells and Daudi cells [3].

Anatomical context of GBX1

  • These studies demonstrated that the GBX2 gene, but not the GBX1 gene, is consistently overexpressed in this panel of human prostate cancer cell lines compared to normal human prostate [1].

Other interactions of GBX1


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