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Pilra  -  paired immunoglobin-like type 2 receptor...

Mus musculus

Synonyms: AV021745, Cell surface receptor FDF03, FDF03, Inhibitory receptor PILR-alpha, Paired immunoglobulin-like type 2 receptor alpha
 
 
 
 
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High impact information on Pilra

  • The FDF03 cytoplasmic tail contained two immunoreceptor tyrosine-based inhibitory motif (ITIM)-like sequences [1].
  • The gene encoding FDF03 mapped to chromosome 7q22 [1].
  • FDF03 was also strongly expressed by monocyte-derived dendritic cells (DC) and preferentially by CD14+/CD1a- DC derived from CD34+ progenitors [1].
  • FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells [1].
  • In this study, we describe human FDF03, a novel member of the Ig superfamily expressed as a monomeric 44-kDa transmembrane glycoprotein and containing a single extracellular V-set Ig-like domain [1].
 

Anatomical context of Pilra

  • FDF03 was mostly detected in hemopoietic tissues and was expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes (B, T, and NK cells), indicating an expression restricted to cells of the myelomonocytic lineage [1].
  • When overexpressed in pervanadate-treated U937 cells, FDF03 was tyrosine-phosphorylated and recruited Src homology-2 (SH2) domain-containing protein tyrosine phosphatase (SHP)-2 and to a lesser extent SHP-1 [1].

References

  1. FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. Fournier, N., Chalus, L., Durand, I., Garcia, E., Pin, J.J., Churakova, T., Patel, S., Zlot, C., Gorman, D., Zurawski, S., Abrams, J., Bates, E.E., Garrone, P. J. Immunol. (2000) [Pubmed]
 
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