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Gene Review

DNAJC13  -  DnaJ (Hsp40) homolog, subfamily C, member 13

Homo sapiens

Synonyms: DnaJ homolog subfamily C member 13, KIAA0678, RME-8, RME8, Required for receptor-mediated endocytosis 8
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Disease relevance of DNAJC13

  • KIAA0678 was considered a good functional candidate gene for NPH3 and SLS3, because molecular cha- perones are involved in the etiology of renal and retinal diseases [1].

High impact information on DNAJC13


Biological context of DNAJC13


Anatomical context of DNAJC13

  • In the macrophage-like coelomocytes, RME-8 localizes to the limiting membrane of large endosomes [3].

Other interactions of DNAJC13


  1. Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein for adolescent nephronophthisis and Senior-Løken syndrome type 3. Volz, A., Melkaoui, R., Hildebrandt, F., Omran, H. Cytogenet. Genome Res. (2002) [Pubmed]
  2. The DnaJ-domain protein RME-8 functions in endosomal trafficking. Girard, M., Poupon, V., Blondeau, F., McPherson, P.S. J. Biol. Chem. (2005) [Pubmed]
  3. RME-8, a conserved J-domain protein, is required for endocytosis in Caenorhabditis elegans. Zhang, Y., Grant, B., Hirsh, D. Mol. Biol. Cell (2001) [Pubmed]
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