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Gene Review

DNAJC25  -  DnaJ (Hsp40) homolog, subfamily C , member 25

Homo sapiens

Synonyms: DnaJ homolog subfamily C member 25, bA16L21.2.1
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Disease relevance of bA16L21.2.1

  • We show that HsDPH3 is the previously described human diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1 and that DPH4 encodes a CSL zinc finger-containing DnaJ-like protein [1].
  • The NMR structure of the N-terminal, DnaJ-like domain of murine polyomavirus tumor antigens (PyJ) has been determined to high precision, with root mean square deviations to the mean structure of 0.38 A for backbone atoms and 0.94 A for all heavy atoms of ordered residues 5-41 and 50-69 [2].
  • Recent studies have shown that DnaJ-like family proteins can inhibit polyglutamine aggregation, a hallmark of many neurodegenerative diseases, including Huntington's disease (HD) [3].
  • By using microarray and an invasion/metastasis lung cell line model, we identified the DnaJ-like heat shock protein 40, HLJ1, and found that the expression of HLJ1 correlates negatively with cancer cell invasion ability [4].
  • Human neurone-specific DnaJ-like proteins, HSJ1a and HSJ1b, possess a J domain and a glycine/phenylalanine-rich region in common with E. coli DnaJ, although the overall amino acid identity is less than 23% [5].

High impact information on bA16L21.2.1


Biological context of bA16L21.2.1


Anatomical context of bA16L21.2.1


Associations of bA16L21.2.1 with chemical compounds

  • Although most DnaJ-like proteins studied are ubiquitously expressed, some have restricted expression, so it is possible that some specific chaperones may affect polyglutamine aggregation in specific neurons [3].

Regulatory relationships of bA16L21.2.1


Other interactions of bA16L21.2.1


  1. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Liu, S., Milne, G.T., Kuremsky, J.G., Fink, G.R., Leppla, S.H. Mol. Cell. Biol. (2004) [Pubmed]
  2. NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens. Berjanskii, M.V., Riley, M.I., Xie, A., Semenchenko, V., Folk, W.R., Van Doren, S.R. J. Biol. Chem. (2000) [Pubmed]
  3. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. Chuang, J.Z., Zhou, H., Zhu, M., Li, S.H., Li, X.J., Sung, C.H. J. Biol. Chem. (2002) [Pubmed]
  4. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. Wang, C.C., Tsai, M.F., Hong, T.M., Chang, G.C., Chen, C.Y., Yang, W.M., Chen, J.J., Yang, P.C. Oncogene (2005) [Pubmed]
  5. Regulation of 70-kDa heat-shock-protein ATPase activity and substrate binding by human DnaJ-like proteins, HSJ1a and HSJ1b. Cheetham, M.E., Jackson, A.P., Anderton, B.H. Eur. J. Biochem. (1994) [Pubmed]
  6. Domain requirements of DnaJ-like (Hsp40) molecular chaperones in the activation of a steroid hormone receptor. Fliss, A.E., Rao, J., Melville, M.W., Cheetham, M.E., Caplan, A.J. J. Biol. Chem. (1999) [Pubmed]
  7. Inhibition of hsc70-catalysed clathrin uncoating by HSJ1 proteins. Cheetham, M.E., Anderton, B.H., Jackson, A.P. Biochem. J. (1996) [Pubmed]
  8. MsJ1, an alfalfa DnaJ-like gene, is tissue-specific and transcriptionally regulated during cell cycle. Frugis, G., Mele, G., Giannino, D., Mariotti, D. Plant Mol. Biol. (1999) [Pubmed]
  9. Molecular cloning, structure, and testis-specific expression of MFSJ1, a member of the DNAJ protein family, in the Japanese monkey (Macaca fuscata). Yu, S.S., Takenaka, O. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  10. Expression of DnaJ homologs and Hsp70 in the Japanese willow (Salix gilgiana Seemen). Futamura, N., Ishiiminami, N., Hayashida, N., Shinohara, K. Plant Cell Physiol. (1999) [Pubmed]
  11. Expression of a novel DnaJA1 alternative splicing in human testis and sperm. Hu, Y., Zhou, Z., Huang, X., Xu, M., Lu, L., Xu, Z., Li, J., Sha, J. Int. J. Androl. (2004) [Pubmed]
  12. Human cDNA encoding DnaJ protein homologue. Oh, S., Iwahori, A., Kato, S. Biochim. Biophys. Acta (1993) [Pubmed]
  13. Normal protein folding machinery. Hartman, D., Gething, M.J. EXS. (1996) [Pubmed]
  14. Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein for adolescent nephronophthisis and Senior-Løken syndrome type 3. Volz, A., Melkaoui, R., Hildebrandt, F., Omran, H. Cytogenet. Genome Res. (2002) [Pubmed]
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