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P2ry4  -  pyrimidinergic receptor P2Y, G-protein...

Mus musculus

Synonyms: P2Y purinoceptor 4, P2Y4, P2Y4R, P2y4r
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High impact information on P2ry4

  • Thus, by the process of elimination, our data suggest that P2Y purinoceptors (P2Y2 or P2Y4) are involved in the Ca(2+)(i) response to fluid flow [1].
  • Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice [2].
  • RT-PCR analysis of isolated colonic crypts revealed P2Y2, P2Y4 and P2Y6 specific transcripts [3].
  • Luminal UTP-stimulated K+ secretion was completely absent in P2Y2/P2Y4 double receptor KO mice [3].
  • To this end P2Y2 and P2Y4 knock-out mice were used to measure distal colonic ion transport in an Ussing chamber [3].

Biological context of P2ry4


Anatomical context of P2ry4

  • In summary, these results indicate that both the P2Y2 and P2Y4 receptors are present in the luminal membrane of mouse distal colonic mucosa, and stimulation of these receptors leads to K+ secretion [3].

Associations of P2ry4 with chemical compounds

  • K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon [3].
  • P2Y4 receptors were not involved, since P2Y4-deficient mice displayed unaltered responses to ATP and UTP.The purinergic receptor antagonist suramin exerted surmountable antagonism for all agonists [6].
  • In 1321N1 transfected cells, the mouse P2Y4 receptor was equally activated by UTP and ATP, and was antagonized by pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) and Reactive Blue 2, and not by suramin [5].


  1. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. You, J., Jacobs, C.R., Steinberg, T.H., Donahue, H.J. J. Biol. Chem. (2002) [Pubmed]
  2. Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice. Robaye, B., Ghanem, E., Wilkin, F., Fokan, D., Van Driessche, W., Schurmans, S., Boeynaems, J.M., Beauwens, R. Mol. Pharmacol. (2003) [Pubmed]
  3. K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon. Matos, J.E., Robaye, B., Boeynaems, J.M., Beauwens, R., Leipziger, J. J. Physiol. (Lond.) (2005) [Pubmed]
  4. The P2Y agonist UTP activates cutaneous afferent fibers. Stucky, C.L., Medler, K.A., Molliver, D.C. Pain (2004) [Pubmed]
  5. Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor. Suarez-Huerta, N., Pouillon, V., Boeynaems, J., Robaye, B. Eur. J. Pharmacol. (2001) [Pubmed]
  6. Pharmacological characterization of nucleotide P2Y receptors on endothelial cells of the mouse aorta. Guns, P.J., Korda, A., Crauwels, H.M., Van Assche, T., Robaye, B., Boeynaems, J.M., Bult, H. Br. J. Pharmacol. (2005) [Pubmed]
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