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Gene Review

SLC16A8  -  solute carrier family 16 (monocarboxylate...

Homo sapiens

Synonyms: MCT 3, MCT3, Monocarboxylate transporter 3, REMP, Solute carrier family 16 member 8
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Disease relevance of SLC16A8

  • This hypothesis could explain the REMP reduction in end-stage uremia and its correction with dialysis [1].
  • The influence of intradialytic REMP increase linked to K+ removal also concerns the correction of metabolic acidosis: the acquired bicarbonate during dialysis increases on reducing removal K+ gradient [1].

High impact information on SLC16A8

  • Using radiation hybrid mapping, the MCT3 gene was mapped to chromosome 22 between markers WI11639 and SGC30687 [2].
  • The human genomic sequence was used to design primers to clone human MCT3 cDNA and to identify a bacterial artificial chromosome clone containing the human MCT3 gene [2].
  • Comparison of the cDNA and genomic sequences revealed that the MCT3 gene was composed of five exons distributed over 5 kb of DNA [2].
  • The human MCT3 cDNA contained a 1512-nucleotide open reading frame with a deduced amino sequence 85% identical to rat MCT3 [2].
  • The retinal pigment epithelium (RPE) expresses a unique member of this family, MCT3 [2].

Biological context of SLC16A8

  • A search of chromosome 22 in the Sanger Centre database confirmed the location of the human MCT3 gene at 22q12.3-q13.2 [2].
  • At the same time points, plasma electrolytes, intra-erythrocytic potassium and the electrical membrane potential at rest (REMP) of the erythrocytic membrane were measured [3].

Associations of SLC16A8 with chemical compounds

  • The effect of chlorpromazine (CPZ), imipramine (IMP), nitrazepam (NZP) and amobarbital sodium (AMOB) on the REM period of sleep (REMP) was investigated on four subjects by means of all-night sleep polygraphy with the schedule PPPDDDPP where P is placebo and D active drug [4].


  1. Hydroelectrolytic equilibrium change in dialysis. Redaelli, B. J. Nephrol. (2001) [Pubmed]
  2. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. Yoon, H., Donoso, L.A., Philp, N.J. Genomics (1999) [Pubmed]
  3. The effect of two different protocols of potassium haemodiafiltration on QT dispersion. Buemi, M., Aloisi, E., Coppolino, G., Loddo, S., Crascì, E., Aloisi, C., Barillà, A., Cosentini, V., Nostro, L., Caccamo, C., Floccari, F., Romeo, A., Frisina, N., Teti, D. Nephrol. Dial. Transplant. (2005) [Pubmed]
  4. Differential effects of chlorpromazine, imipramine, nitrazepam and amobarbital on REM sleep and REM density in man. Okuma, T., Hata, N., Fujii, S. Folia psychiatrica et neurologica japonica. (1975) [Pubmed]
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