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SLC16A8  -  solute carrier family 16 (monocarboxylate...

Gallus gallus

 
 
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High impact information on SLC16A8

  • The deduced amino-acid sequence of REMP shares 32.9% identity with MCT1, a monocarboxylate transporter (Garcia, Goldstein, Pathak, Anderson, and Brown, Cell, 76, 865-873, 1994) [1].
  • The gene encoding REMP was isolated from an E15 chick RPE cDNA library, cloned into lambda gt11, and screened with MAb 3C4 [1].
  • REMP was first detected in the chick RPE at Embryonic Day 5 (E5) in both apical and basolateral membranes [1].
  • Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast [2].
  • In addition, MCT3 was highly resistant to a number of "classical" inhibitors of lactate transport [2].
 

Biological context of SLC16A8

  • The MCT3 gene is distributed over 8 kb of DNA and is composed of 6 exons [3].
  • To determine the exon-intron structure and to understand the elements that control the tissue specific and developmental expression of MCT3, the MCT3 gene was cloned and sequenced from a chicken genomic library [3].
 

Anatomical context of SLC16A8

  • MCT3 is a monocarboxylate transporter that is specifically expressed on the basolateral membrane of retinal pigment epithelial cells (RPE) [3].
 

Analytical, diagnostic and therapeutic context of SLC16A8

References

  1. Developmental expression and molecular cloning of REMP, a novel retinal epithelial membrane protein. Philp, N., Chu, P., Pan, T.C., Zhang, R.Z., Chu, M.L., Stark, K., Boettiger, D., Yoon, H., Kieber-Emmons, T. Exp. Cell Res. (1995) [Pubmed]
  2. Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast. Grollman, E.F., Philp, N.J., McPhie, P., Ward, R.D., Sauer, B. Biochemistry (2000) [Pubmed]
  3. Genomic structure and developmental expression of the chicken nonocarboxylate transporter MCT3 gene. Yoon, H., Philp, N.J. Exp. Eye Res. (1998) [Pubmed]
 
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