The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Barbamyl     sodium5-ethyl-5-(3- methylbutyl)-4,6-dioxo...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of amobarbital


Psychiatry related information on amobarbital


High impact information on amobarbital


Biological context of amobarbital

  • A computerised evoked potential test for the lateralisation of speech dominance was compared with the intracarotid sodium amylobarbitone test in 22 epileptic patients [15].
  • Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test [16].
  • The unique contribution of neuropsychology, which includes standard neuropsychological assessment and intracarotid sodium amytal (Wada) testing, is its capability to predict lateralization and often localization of a brain lesion based on cognitive function and dysfunction, which can be demonstrated also in the absence of a structural lesion [17].

Anatomical context of amobarbital


Associations of amobarbital with other chemical compounds


Gene context of amobarbital


Analytical, diagnostic and therapeutic context of amobarbital

  • Sodium Amytal inhibition of NADH oxidation resulted in a homogeneous increase in NADH fluorescence, while lowering perfusion pressure from 55 to 10 torr caused a heterogeneous increase in NADH fluorescence, reflecting the heterogeneous oxygen delivery at this low pressure [32].
  • Trans-synaptic regulation of muscarinic, peptidergic, and purinergic responses after denervation has been reported previously in rat parotid acinar cells (McMillian, M. K., Soltoff, S. P., Cantley, L. C., Rudel, R., and Talamo, B. R. (1993) Br. J. Pharmacol. 108, 453-461) [33].
  • Sodium amylobarbitone in the differential diagnosis of confusion [34].
  • Mapping distribution of amobarbital sodium in the intracarotid Wada test with use of Tc-99m HMPAO with SPECT [35].
  • This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation [3].


  1. Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow. Ambrosio, G., Zweier, J.L., Duilio, C., Kuppusamy, P., Santoro, G., Elia, P.P., Tritto, I., Cirillo, P., Condorelli, M., Chiariello, M. J. Biol. Chem. (1993) [Pubmed]
  2. Electrographic and clinical effects of intracarotid sodium amobarbital on bilateral myoclonic status epilepticus. McCutchen, C.B., Vignaendra, V., Chatrian, G.E. Neurology (1977) [Pubmed]
  3. Effect of intravenous sodium amytal on cutaneous limb temperatures and sympathetic skin responses in normal subjects and pain patients with and without Complex Regional Pain Syndromes (type I and II). I. Mailis, A., Plapler, P., Ashby, P., Shoichet, R., Roe, S. Pain (1997) [Pubmed]
  4. Dopaminergic function in two patients with catalepsy. Cervantes, P., Lal, S., Smith, F., Guyda, H. Acta psychiatrica Scandinavica. (1977) [Pubmed]
  5. Sodium amobarbital response during simulated catatonia. Dysken, M.W., Steinberg, J., Davis, J.M. Biol. Psychiatry (1979) [Pubmed]
  6. Right hemisphere speech perception revealed by amobarbital injection and electrical interference. Boatman, D., Hart, J., Lesser, R.P., Honeycutt, N., Anderson, N.B., Miglioretti, D., Gordon, B. Neurology (1998) [Pubmed]
  7. Quantitative analysis of hemispatial neglect in the intracarotid sodium amobarbital (ISA) test. Ahern, G.L., Herring, A.M., Labiner, D.M., Weinand, M.E. Journal of the International Neuropsychological Society : JINS. (1998) [Pubmed]
  8. Writing hand posture and cerebral dominance for speech. Strauss, E., Wada, J., Kosaka, B. Cortex; a journal devoted to the study of the nervous system and behavior. (1984) [Pubmed]
  9. The hippocampus: functional and structural correlations. Baxendale, S.A. Seizure : the journal of the British Epilepsy Association. (1995) [Pubmed]
  10. Decrease in L-type pyruvate kinase activity in rat liver by some promoters of hepatocarcinogenesis. Yanagi, S., Sakamoto, M., Ninomiya, Y., Kamiya, T. J. Natl. Cancer Inst. (1984) [Pubmed]
  11. The corpus callosum is larger with right-hemisphere cerebral speech dominance. O'Kusky, J., Strauss, E., Kosaka, B., Wada, J., Li, D., Druhan, M., Petrie, J. Ann. Neurol. (1988) [Pubmed]
  12. Resumption of behavior following intracarotid sodium amobarbital injection. Rausch, R., Fedio, P., Ary, C.M., Engel, J., Crandall, P.H. Ann. Neurol. (1984) [Pubmed]
  13. Correlates of arterial-filling patterns in the intracarotid amobarbital procedure. Perrine, K., Devinsky, O., Luciano, D.J., Choi, I.S., Nelson, P.K. Arch. Neurol. (1995) [Pubmed]
  14. Mapping the distribution of amobarbital sodium in the intracarotid Wada test by use of Tc-99m HMPAO with SPECT. Jeffery, P.J., Monsein, L.H., Szabo, Z., Hart, J., Fisher, R.S., Lesser, R.P., Debrun, G.M., Gordon, B., Wagner, H.N., Camargo, E.E. Radiology. (1991) [Pubmed]
  15. Lateralisation of speech dominance by spectral analysis of evoked potentials. Davis, A.E., Wada, J.A. J. Neurol. Neurosurg. Psychiatr. (1977) [Pubmed]
  16. Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test. Ahern, G.L., Sollers, J.J., Lane, R.D., Labiner, D.M., Herring, A.M., Weinand, M.E., Hutzler, R., Thayer, J.F. Epilepsia (2001) [Pubmed]
  17. Contribution of neuropsychology to epilepsy surgery. Andelman, F., Neufeld, M.Y., Fried, I. The Israel journal of psychiatry and related sciences. (2004) [Pubmed]
  18. Memory performance on the intracarotid amobarbital procedure as a predicator of seizure focus. Roman, D.D., Beniak, T.E., Nugent, S. Epilepsy Res. (1996) [Pubmed]
  19. Posterior cerebral artery Wada test: sodium amytal distribution and functional deficits. Urbach, H., Klemm, E., Linke, D.B., Behrends, K., Biersack, H.J., Schramm, J., Schild, H.H. Neuroradiology. (2001) [Pubmed]
  20. Selective deficit of one language in a bilingual patient following surgery in the left perisylvian area. Gomez-Tortosa, E., Martin, E.M., Gaviria, M., Charbel, F., Ausman, J.I. Brain and language. (1995) [Pubmed]
  21. Crossed cerebellar diaschisis in intracarotid sodium amytal procedures: a SPECT study. Kurthen, M., Reichmann, K., Linke, D.B., Biersack, H.J., Reuter, B.M., Durwen, H.F., Grünwald, F. Acta neurologica Scandinavica. (1990) [Pubmed]
  22. Maculo-papillary branch retinal artery occlusions following the Wada test. Müller, E., Huk, W., Pauli, E., Wenkel, H. Graefes Arch. Clin. Exp. Ophthalmol. (2000) [Pubmed]
  23. The neural substrate of memory impairment demonstrated by the intracarotid amobarbital procedure. Sass, K.J., Lencz, T., Westerveld, M., Novelly, R.A., Spencer, D.D., Kim, J.H. Arch. Neurol. (1991) [Pubmed]
  24. Lormetazepam and amobarbital sodium in the outpatient treatment of insomnia: a controlled trial. Ansseau, M., Diricq, S. Clinical therapeutics. (1983) [Pubmed]
  25. Tuinal as a drug of abuse. Dymock, R.B., James, R.A., Lokan, R.J. Med. J. Aust. (1980) [Pubmed]
  26. Cerebral anesthesia for localization of speech: the contribution of W. James Gardner. Harris, L.J., Snyder, P.J. Brain and language. (1997) [Pubmed]
  27. Differential effects of chlorpromazine, imipramine, nitrazepam and amobarbital on REM sleep and REM density in man. Okuma, T., Hata, N., Fujii, S. Folia psychiatrica et neurologica japonica. (1975) [Pubmed]
  28. Acute dystonia during fixed-dose neuroleptic treatment. Singh, H., Levinson, D.F., Simpson, G.M., Lo, E.S., Friedman, E. Journal of clinical psychopharmacology. (1990) [Pubmed]
  29. Episodic memory dysfunction during sodium amytal testing of epileptic patients in relation to posterior cerebral artery perfusion. Morton, N., Polkey, C.E., Cox, T., Morris, R.G. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1996) [Pubmed]
  30. Bizarre behavior during intracarotid sodium amytal testing (Wada test): are they predictable? de Paola, L., Mäder, M.J., Germiniani, F.M., Coral, P., Zavala, J.A., Watzo, D.J., Kanegusuku, J., Silvado, C.E., Werneck, L.C. Arquivos de neuro-psiquiatria. (2004) [Pubmed]
  31. Further examples confirming the existence of Pi null (Pi-). Martin, J.P. Pathol. Biol. (1975) [Pubmed]
  32. Ischemic areas in perfused rat hearts: measurement by NADH fluorescence photography. Barlow, C.H., Chance, B. Science (1976) [Pubmed]
  33. Expression and trans-synaptic regulation of P2x4 and P2z receptors for extracellular ATP in parotid acinar cells. Effects of parasympathetic denervation. Tenneti, L., Gibbons, S.J., Talamo, B.R. J. Biol. Chem. (1998) [Pubmed]
  34. Sodium amylobarbitone in the differential diagnosis of confusion. Ward, N.G., Rowlett, D.B., Burke, P. The American journal of psychiatry. (1978) [Pubmed]
  35. Mapping distribution of amobarbital sodium in the intracarotid Wada test with use of Tc-99m HMPAO with SPECT. Friedman, D. Radiology. (1991) [Pubmed]
WikiGenes - Universities