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TSSK2  -  testis-specific serine kinase 2

Homo sapiens

Synonyms: DGS-G, DGSG, DiGeorge syndrome protein G, FLJ38613, SPOGA2, ...
 
 
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High impact information on TSSK2

  • There was no evidence of any microsatellite allele disturbances on chromosome 2q in the region homologous to the tsk2 locus or the region containing the interleukin-1 family [1].
  • METHODS: A candidate gene approach was used in which microsatellite alleles on human chromosomes 15q and 2q, homologous to the murine tight skin 1 (tsk1) and tsk2 loci, respectively, were analyzed in Choctaw SSc cases and race-matched normal controls for possible disease association [1].
  • TSSK 2 expressed in yeast and bacteria was able to autophosphorylate and also phosphorylated recombinant TSKS in vitro [2].
  • Two members of the human testis-specific serine/threonine (Ser/Thr) kinase family, TSSK 1 and TSSK 2, were cloned and sequenced from a human testis adaptor-ligated cDNA library using a PCR strategy [2].
 

Anatomical context of TSSK2

  • Antibodies against recombinant TSSK 2 demonstrated that a member of the TSSK family was present in human testis and localized to the equatorial segment of ejaculated human sperm [2].
 

Other interactions of TSSK2

  • Human TSSK 2 and TSKS interacted in a yeast two-hybrid system and also co-immunoprecipitated after in vitro translation [2].

References

  1. Association of microsatellite markers near the fibrillin 1 gene on human chromosome 15q with scleroderma in a Native American population. Tan, F.K., Stivers, D.N., Foster, M.W., Chakraborty, R., Howard, R.F., Milewicz, D.M., Arnett, F.C. Arthritis Rheum. (1998) [Pubmed]
  2. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. Hao, Z., Jha, K.N., Kim, Y.H., Vemuganti, S., Westbrook, V.A., Chertihin, O., Markgraf, K., Flickinger, C.J., Coppola, M., Herr, J.C., Visconti, P.E. Mol. Hum. Reprod. (2004) [Pubmed]
 
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