The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PPIL2  -  peptidylprolyl isomerase (cyclophilin)-like 2

Homo sapiens

Synonyms: CYC4, CYP60, Cyclophilin-60, Cyclophilin-like protein Cyp-60, Cyp-60, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PPIL2


High impact information on PPIL2

  • Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60 [1].
  • We have determined the solution structure of the two domain protein hPin1-(1-163) and its separately expressed PPIase domain (50-163) (hPin1PPIase) with an root mean square deviation of <0.5 A over backbone atoms using NMR [2].
  • Also crucial were active site residues of CyPA, because rotamase-defective CyPA mutants failed to initiate signaling events [3].
  • The association of PPIL2 with BACE expression and its requirement for Abeta production suggests new approaches to discover disease modifying agents for AD [4].
  • In addition, hCyP-60 contains a tyrosine residue (Tyr 389) instead of a tryptophan residue found in most eukaryotic cyclophilins at a position important for cyclosporin binding [5].

Biological context of PPIL2


Anatomical context of PPIL2


Physical interactions of PPIL2

  • We have identified a novel human cyclophilin (hCyP-60) which interacts with the proteinase inhibitor eglin c using the yeast two-hybrid system [5].

Other interactions of PPIL2

  • These results suggest that Cyp60 plays an important role in the translocation of CD147 to the cell surface [1].


  1. Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. Pushkarsky, T., Yurchenko, V., Vanpouille, C., Brichacek, B., Vaisman, I., Hatakeyama, S., Nakayama, K.I., Sherry, B., Bukrinsky, M.I. J. Biol. Chem. (2005) [Pubmed]
  2. Structural analysis of the mitotic regulator hPin1 in solution: insights into domain architecture and substrate binding. Bayer, E., Goettsch, S., Mueller, J.W., Griewel, B., Guiberman, E., Mayr, L.M., Bayer, P. J. Biol. Chem. (2003) [Pubmed]
  3. Active site residues of cyclophilin A are crucial for its signaling activity via CD147. Yurchenko, V., Zybarth, G., O'Connor, M., Dai, W.W., Franchin, G., Hao, T., Guo, H., Hung, H.C., Toole, B., Gallay, P., Sherry, B., Bukrinsky, M. J. Biol. Chem. (2002) [Pubmed]
  4. A genome wide analysis of ubiquitin ligases in APP processing identifies a novel regulator of BACE1 mRNA levels. Espeseth, A.S., Huang, Q., Gates, A., Xu, M., Yu, Y., Simon, A.J., Shi, X.P., Zhang, X., Hodor, P., Stone, D.J., Burchard, J., Cavet, G., Bartz, S., Linsley, P., Ray, W.J., Hazuda, D. Mol. Cell. Neurosci. (2006) [Pubmed]
  5. Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c. Wang, B.B., Hayenga, K.J., Payan, D.G., Fisher, J.M. Biochem. J. (1996) [Pubmed]
WikiGenes - Universities