Gene Review:
BSG - basigin (Ok blood group)
Homo sapiens
Synonyms:
5F7, Basigin, CD147, Collagenase stimulatory factor, EMMPRIN, ...
- Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions. Sun, J., Hemler, M.E. Cancer Res. (2001)
- Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. Pushkarsky, T., Yurchenko, V., Vanpouille, C., Brichacek, B., Vaisman, I., Hatakeyama, S., Nakayama, K.I., Sherry, B., Bukrinsky, M.I. J. Biol. Chem. (2005)
- Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Kanekura, T., Chen, X., Kanzaki, T. Int. J. Cancer (2002)
- EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. Sier, C.F., Zuidwijk, K., Zijlmans, H.J., Hanemaaijer, R., Mulder-Stapel, A.A., Prins, F.A., Dreef, E.J., Kenter, G.G., Fleuren, G.J., Gorter, A. Int. J. Cancer (2006)
- Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. Kuang, Y.H., Chen, X., Su, J., Wu, L.S., Li, J., Chang, J., Qiu, Y., Chen, Z.S., Kanekura, T. J. Proteome Res. (2008)
- EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer. Ju, X.Z., Yang, J.M., Zhou, X.Y., Li, Z.T., Wu, X.H. Clin. Cancer Res. (2008)
- CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Zhou, S., Zhou, H., Walian, P.J., Jap, B.K. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Immunochemical localization and amino acid sequences of crossreactive epitopes within the group A streptococcal M6 protein. Jones, K.F., Khan, S.A., Erickson, B.W., Hollingshead, S.K., Scott, J.R., Fischetti, V.A. J. Exp. Med. (1986)
- Conversion of an M- group A streptococcus to M+ by transfer of a plasmid containing an M6 gene. Scott, J.R., Guenthner, P.C., Malone, L.M., Fischetti, V.A. J. Exp. Med. (1986)
- CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. Kirk, P., Wilson, M.C., Heddle, C., Brown, M.H., Barclay, A.N., Halestrap, A.P. EMBO J. (2000)
- Clinicopathological significance of expression of paxillin, syndecan-1 and EMMPRIN in hepatocellular carcinoma. Li, H.G., Xie, D.R., Shen, X.M., Li, H.H., Zeng, H., Zeng, Y.J. World J. Gastroenterol. (2005)
- CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. Pushkarsky, T., Zybarth, G., Dubrovsky, L., Yurchenko, V., Tang, H., Guo, H., Toole, B., Sherry, B., Bukrinsky, M. Proc. Natl. Acad. Sci. U.S.A. (2001)
- PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. Davidson, B., Goldberg, I., Gotlieb, W.H., Kopolovic, J., Ben-Baruch, G., Reich, R. Clin. Cancer Res. (2003)
- Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells. Haug, C., Lenz, C., Díaz, F., Bachem, M.G. Arterioscler. Thromb. Vasc. Biol. (2004)
- High incidence of EMMPRIN expression in human tumors. Riethdorf, S., Reimers, N., Assmann, V., Kornfeld, J.W., Terracciano, L., Sauter, G., Pantel, K. Int. J. Cancer (2006)
- Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways. Tang, J., Wu, Y.M., Zhao, P., Yang, X.M., Jiang, J.L., Chen, Z.N. Cell. Mol. Life Sci. (2008)
- Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Gabison, E.E., Mourah, S., Steinfels, E., Yan, L., Hoang-Xuan, T., Watsky, M.A., De Wever, B., Calvo, F., Mauviel, A., Menashi, S. Am. J. Pathol. (2005)
- Membrane Type 1 Matrix Metalloproteinase (MT1-MMP/MMP-14) Cleaves and Releases a 22-kDa Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Fragment from Tumor Cells. Egawa, N., Koshikawa, N., Tomari, T., Nabeshima, K., Isobe, T., Seiki, M. J. Biol. Chem. (2006)
- Identification and characterization of extracellular matrix metalloproteinase inducer in human endometrium during the menstrual cycle in vivo and in vitro. Noguchi, Y., Sato, T., Hirata, M., Hara, T., Ohama, K., Ito, A. J. Clin. Endocrinol. Metab. (2003)
- EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface. Guo, H., Li, R., Zucker, S., Toole, B.P. Cancer Res. (2000)
- Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain. Yurchenko, V., Pushkarsky, T., Li, J.H., Dai, W.W., Sherry, B., Bukrinsky, M. J. Biol. Chem. (2005)
- Extracellular matrix metalloproteinase inducer regulates metalloproteinases in human uterine endometrium. Braundmeier, A.G., Fazleabas, A.T., Lessey, B.A., Guo, H., Toole, B.P., Nowak, R.A. J. Clin. Endocrinol. Metab. (2006)
- Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Deora, A.A., Philp, N., Hu, J., Bok, D., Rodriguez-Boulan, E. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Caveolin-1 regulates matrix metalloproteinases-1 induction and CD147/EMMPRIN cell surface clustering. Tang, W., Hemler, M.E. J. Biol. Chem. (2004)
- Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction. Schmidt, R., Bültmann, A., Ungerer, M., Joghetaei, N., Bülbül, O., Thieme, S., Chavakis, T., Toole, B.P., Gawaz, M., Schömig, A., May, A.E. Circulation (2006)
- Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production. Zhu, P., Ding, J., Zhou, J., Dong, W.J., Fan, C.M., Chen, Z.N. Arthritis Res. Ther. (2005)
- Regulation of matrix metalloproteinases and their inhibitors in the left ventricular myocardium of patients with aortic stenosis. Fielitz, J., Leuschner, M., Zurbrügg, H.R., Hannack, B., Pregla, R., Hetzer, R., Regitz-Zagrosek, V. J. Mol. Med. (2004)
- Expression of the extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase-2 in bronchopulmonary and breast lesions. Caudroy, S., Polette, M., Tournier, J.M., Burlet, H., Toole, B., Zucker, S., Birembaut, P. J. Histochem. Cytochem. (1999)
- Cytokines regulate matrix metalloproteinases in human uterine endometrial fibroblast cells through a mechanism that does not involve increases in extracellular matrix metalloproteinase inducer. Braundmeier, A.G., Nowak, R.A. Am. J. Reprod. Immunol. (2006)
- Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells. Yang, J.M., Xu, Z., Wu, H., Zhu, H., Wu, X., Hait, W.N. Mol. Cancer Res. (2003)
- Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms. Sluijter, J.P., Pulskens, W.P., Schoneveld, A.H., Velema, E., Strijder, C.F., Moll, F., de Vries, J.P., Verheijen, J., Hanemaaijer, R., de Kleijn, D.P., Pasterkamp, G. Stroke (2006)