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Gene Review:

Clec5a - C-type lectin domain family 5, member a

Mus musculus

Synonyms: C-type lectin domain family 5 member A, C-type lectin superfamily member 5, Clecsf5, Ly100, MDL-1, ...

Yim, D. et al., Aoki, N. et al., Bakker, A.B. et al.

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High impact information on Clec5a

Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells [1].
In contrast, expression of both MDL-1 and TREM-1 was markedly induced by mycobacterial infection and such induction was inhibited by concurrent exposure to IFN-gamma [2].
Porcine MDL-1 contains a conserved lysine in the transmembrane domain [3].
There are six putative N-linked glycosylation sites in the MDL-1 long form [3].
In this study, we report the molecular cloning of two isoforms of porcine MDL-1 cDNA from pulmonary alveolar macrophages [3].

Anatomical context of Clec5a

MDL-1 transcripts were detected exclusively in macrophages and monocytes by RT-PCR [3].

Analytical, diagnostic and therapeutic context of Clec5a

Molecular cloning and expression pattern of porcine myeloid DAP12-associating lectin-1 [3].

References

Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Bakker, A.B., Baker, E., Sutherland, G.R., Phillips, J.H., Lanier, L.L. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
Differential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection. Aoki, N., Zganiacz, A., Margetts, P., Xing, Z. Infect. Immun. (2004) [Pubmed]
Molecular cloning and expression pattern of porcine myeloid DAP12-associating lectin-1. Yim, D., Jie, H.B., Sotiriadis, J., Kim, Y.S., Kim, Y.B. Cell. Immunol. (2001) [Pubmed]

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