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Gene Review

Sigirr  -  single immunoglobulin and toll-interleukin...

Mus musculus

Synonyms: AI256711, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, TIR8, ...
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Disease relevance of Sigirr


High impact information on Sigirr


Associations of Sigirr with chemical compounds

  • Accordingly, blocking IL-1beta and TNF-alpha with a mix of anti-cytokine Abs, significantly prolonged survival of Tir8(-/-) mice [3].


  1. Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Garlanda, C., Riva, F., Polentarutti, N., Buracchi, C., Sironi, M., De Bortoli, M., Muzio, M., Bergottini, R., Scanziani, E., Vecchi, A., Hirsch, E., Mantovani, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis. Dimcheff, D.E., Volkert, L.G., Li, Y., DeLucia, A.L., Lynch, W.P. Retrovirology (2006) [Pubmed]
  3. Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling. Garlanda, C., Di Liberto, D., Vecchi, A., La Manna, M.P., Buracchi, C., Caccamo, N., Salerno, A., Dieli, F., Mantovani, A. J. Immunol. (2007) [Pubmed]
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