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Gene Review:

Sigirr - single immunoglobulin and toll-interleukin...

Mus musculus

Synonyms: AI256711, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, TIR8, ...

Garlanda, C. et al., Dimcheff, D.E. et al., Garlanda, C. et al.

Volkert, Lynch, Dimcheff, Li, DeLucia,

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Disease relevance of Sigirr

Tir8-deficient mice had normal susceptibility to systemic lipopolysaccharide toxicity and to i.p. or s.c. inflammation [1].

High impact information on Sigirr

Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family [1].
Tir8-deficient DC showed increased cytokine production in response to TLR agonists (lipopolysaccharide, CpG oligodeoxynucleotides) [1].
Here we report that Tir8 has a unique pattern of expression, which includes mucosal tissues and dendritic cells (DC) [1].
Thus, TIR8 represents a negative pathway of regulation of the IL-1 receptor/TLR system, expressed in epithelial cells and DC, crucial for tuning inflammation in the gastrointestinal tract [1].
Validation experiments for these genes by Taqman real-time RT-PCR indicated that only single Ig IL-1 receptor related protein (SIGIRR) transcript was consistently altered in culture; however, SIGIRR changes were not observed in enriched microglial fractions from infected brains [2].

Associations of Sigirr with chemical compounds

Accordingly, blocking IL-1beta and TNF-alpha with a mix of anti-cytokine Abs, significantly prolonged survival of Tir8(-/-) mice [3].

References

Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Garlanda, C., Riva, F., Polentarutti, N., Buracchi, C., Sironi, M., De Bortoli, M., Muzio, M., Bergottini, R., Scanziani, E., Vecchi, A., Hirsch, E., Mantovani, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis. Dimcheff, D.E., Volkert, L.G., Li, Y., DeLucia, A.L., Lynch, W.P. Retrovirology (2006) [Pubmed]
Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling. Garlanda, C., Di Liberto, D., Vecchi, A., La Manna, M.P., Buracchi, C., Caccamo, N., Salerno, A., Dieli, F., Mantovani, A. J. Immunol. (2007) [Pubmed]

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SIGIRR	Bos taurus
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sigirr	Danio rerio
SIGIRR	Gallus gallus
SIGIRR	Homo sapiens
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sigirr	Xenopus (Silurana) tropicalis

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