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Gene Review

SIGIRR  -  single immunoglobulin and toll-interleukin...

Homo sapiens

Synonyms: Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, TIR8, Toll/interleukin-1 receptor 8, ...
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Disease relevance of SIGIRR


High impact information on SIGIRR

  • Whereas both the extracellular Ig domain and the intracellular TIR domains are important for SIGIRR to inhibit IL-1 signaling, only the TIR domain is necessary for SIGIRR to inhibit LPS signaling [4].
  • Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients [5].
  • To investigate whether polymorphisms in these genes were associated with asthma or asthma-related phenotypes, we screened these genes for polymorphisms by direct sequencing of 24 asthmatics and identified 19 variants in IRAK-M and 12 variants in SIGIRR [6].
  • None of the alleles or haplotypes of IRAK-M and SIGIRR were associated with asthma susceptibility or asthma-related phenotype [6].
  • In the kidney, the organ with highest mRNA levels, TIR8 expression was confined to epithelial cells and, in situ, to tubular epithelium [7].

Anatomical context of SIGIRR

  • Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no TIR8, with the exception of the mouse GG2EE macrophage line [7].

Associations of SIGIRR with chemical compounds

  • The Toll-interleukin-1 receptor (TIR) domain-containing orphan receptor SIGIRR (single immunoglobulin interleukin-1 receptor-related protein) acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling [4].

Regulatory relationships of SIGIRR


Other interactions of SIGIRR


  1. SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. Huang, X., Hazlett, L.D., Du, W., Barrett, R.P. J. Immunol. (2006) [Pubmed]
  2. Impaired monocyte Toll-like receptor-4 signaling in trauma and sepsis: is SIGIRR the answer? Wang, J.E., Dahle, M.K., Aasen, A.O. Crit. Care Med. (2006) [Pubmed]
  3. Gene expression clusters of a lipopolysaccharide-stimulated pathway in peripheral blood monocytes of Japanese patients with Crohn's disease. Naito, Y., Takagi, T., Mizushima, K., Ueta, M., Kinoshita, S., Handa, O., Kokura, S., Ichikawa, H., Yoshida, N., Yoshikawa, T. Aliment. Pharmacol. Ther. (2006) [Pubmed]
  4. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. Qin, J., Qian, Y., Yao, J., Grace, C., Li, X. J. Biol. Chem. (2005) [Pubmed]
  5. Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Adib-Conquy, M., Adrie, C., Fitting, C., Gattolliat, O., Beyaert, R., Cavaillon, J.M. Crit. Care Med. (2006) [Pubmed]
  6. An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway. Nakashima, K., Hirota, T., Obara, K., Shimizu, M., Jodo, A., Kameda, M., Doi, S., Fujita, K., Shirakawa, T., Enomoto, T., Kishi, F., Yoshihara, S., Matsumoto, K., Saito, H., Suzuki, Y., Nakamura, Y., Tamari, M. J. Hum. Genet. (2006) [Pubmed]
  7. Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Polentarutti, N., Rol, G.P., Muzio, M., Bosisio, D., Camnasio, M., Riva, F., Zoja, C., Benigni, A., Tomasoni, S., Vecchi, A., Garlanda, C., Mantovani, A. Eur. Cytokine Netw. (2003) [Pubmed]
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