Gene Review:
SIGIRR - single immunoglobulin and toll-interleukin...
Homo sapiens
Synonyms:
Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, TIR8, Toll/interleukin-1 receptor 8, ...
- SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. Huang, X., Hazlett, L.D., Du, W., Barrett, R.P. J. Immunol. (2006)
- Impaired monocyte Toll-like receptor-4 signaling in trauma and sepsis: is SIGIRR the answer? Wang, J.E., Dahle, M.K., Aasen, A.O. Crit. Care Med. (2006)
- Gene expression clusters of a lipopolysaccharide-stimulated pathway in peripheral blood monocytes of Japanese patients with Crohn's disease. Naito, Y., Takagi, T., Mizushima, K., Ueta, M., Kinoshita, S., Handa, O., Kokura, S., Ichikawa, H., Yoshida, N., Yoshikawa, T. Aliment. Pharmacol. Ther. (2006)
- SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. Qin, J., Qian, Y., Yao, J., Grace, C., Li, X. J. Biol. Chem. (2005)
- Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Adib-Conquy, M., Adrie, C., Fitting, C., Gattolliat, O., Beyaert, R., Cavaillon, J.M. Crit. Care Med. (2006)
- An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway. Nakashima, K., Hirota, T., Obara, K., Shimizu, M., Jodo, A., Kameda, M., Doi, S., Fujita, K., Shirakawa, T., Enomoto, T., Kishi, F., Yoshihara, S., Matsumoto, K., Saito, H., Suzuki, Y., Nakamura, Y., Tamari, M. J. Hum. Genet. (2006)
- Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Polentarutti, N., Rol, G.P., Muzio, M., Bosisio, D., Camnasio, M., Riva, F., Zoja, C., Benigni, A., Tomasoni, S., Vecchi, A., Garlanda, C., Mantovani, A. Eur. Cytokine Netw. (2003)