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Gene Review:

Prkag3 - protein kinase, AMP-activated, gamma 3 non...

Mus musculus

Synonyms: 5'-AMP-activated protein kinase subunit gamma-3, AMPK gamma3, AMPK subunit gamma-3, AMPKg3, AMPKg3L, ...

Nilsson, E.C. et al., Barnes, B.R. et al., Barnes, B.R. et al., Barnes, B.R. et al.

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High impact information on Prkag3

Evidence is provided for coordinated and reciprocal regulation of multiple key components in glucose and fat metabolism, as well as skeletal muscle ergogenics in TgPrkag3(225Q) and Prkag3(-/-) mice [1].
We determined AMPK gamma3-dependent regulation of gene expression by analyzing global transcription profiles in glycolytic skeletal muscle from gamma3 mutant transgenic and knock-out mice using oligonucleotide microarray technology [1].
In contrast, ACC phosphorylation and triglyceride content was similar between wild-type and Prkag3(-/-) mice [2].
Expression of lipoprotein lipase 1, carnitine palmitoyl transferase 1b, and 3-hydroxyacyl-CoA dehydrogenase was increased in Tg-Prkag3(225Q) mice, with opposing effects in Prkag3(-/-) mice after exercise [2].
Furthermore, mutations in the AMPK gamma3-isoform may provide protection from diet-induced insulin resistance by increasing lipid oxidation in the presence of increased lipid supply [3].

Analytical, diagnostic and therapeutic context of Prkag3

We used AMPK3 transgenic (Tg-Prkag3225Q) and knockout (Prkag3-/-) mice to determine the relationship between AMPK activity, glycogen content, and ergogenics (ability to perform work) in isolated extensor digitorum longus skeletal muscle after contractions induced by electrical stimulation [4].

References

Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice. Nilsson, E.C., Long, Y.C., Martinsson, S., Glund, S., Garcia-Roves, P., Svensson, L.T., Andersson, L., Zierath, J.R., Mahlapuu, M. J. Biol. Chem. (2006) [Pubmed]
Changes in Exercise-Induced Gene Expression in 5'-AMP-Activated Protein Kinase {gamma}3-Null and {gamma}3 R225Q Transgenic Mice. Barnes, B.R., Long, Y.C., Steiler, T.L., Leng, Y., Galuska, D., Wojtaszewski, J.F., Andersson, L., Zierath, J.R. Diabetes (2005) [Pubmed]
Role of AMP--activated protein kinase in the control of glucose homeostasis. Barnes, B.R., Zierath, J.R. Curr. Mol. Med. (2005) [Pubmed]
5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics. Barnes, B.R., Glund, S., Long, Y.C., Hjälm, G., Andersson, L., Zierath, J.R. FASEB J. (2005) [Pubmed]

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