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Gene Review

Kirrel2  -  kin of IRRE like 2 (Drosophila)

Mus musculus

Synonyms: C330019F22Rik, Kin of IRRE-like protein 2, Kin of irregular chiasm-like protein 2, NEPH3, NLG1, ...
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Disease relevance of Kirrel2


High impact information on Kirrel2

  • Using the transgenic mouse in which the majority of OSNs express a particular OR, we identified such genes coding for the homophilic adhesive molecules Kirrel2/Kirrel3 and repulsive molecules ephrin-A5/EphA5 [2].
  • Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets [1].
  • Furthermore, adherens junctions (AJs) were formed around the apical end of processes extending from Neph3- and Dll1 mRNA-positive postmitotic precursors [3].
  • In this study, we have identified Neph3 as a specific marker for early postmitotic neural precursors in the VZ of the developing spinal cord [3].

Analytical, diagnostic and therapeutic context of Kirrel2


  1. Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. Sun, C., Kilburn, D., Lukashin, A., Crowell, T., Gardner, H., Brundiers, R., Diefenbach, B., Carulli, J.P. Genomics (2003) [Pubmed]
  2. A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting. Serizawa, S., Miyamichi, K., Takeuchi, H., Yamagishi, Y., Suzuki, M., Sakano, H. Cell (2006) [Pubmed]
  3. Migrating postmitotic neural precursor cells in the ventricular zone extend apical processes and form adherens junctions near the ventricle in the developing spinal cord. Minaki, Y., Mizuhara, E., Morimoto, K., Nakatani, T., Sakamoto, Y., Inoue, Y., Satoh, K., Imai, T., Takai, Y., Ono, Y. Neurosci. Res. (2005) [Pubmed]
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