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Gene Review

KIRREL2  -  kin of IRRE like 2 (Drosophila)

Homo sapiens

Synonyms: DKFZp564A1164, FILTRIN, Kin of IRRE-like protein 2, Kin of irregular chiasm-like protein 2, MGC15718, ...
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High impact information on KIRREL2


Biological context of KIRREL2


Anatomical context of KIRREL2

  • Additionally, we studied whether densin and filtrin, another molecule shared between the kidney podocytes and pancreatic islet cells, can act as autoantigens and whether autoantibodies against these can be detected in patients with type 1 diabetes [3].

Other interactions of KIRREL2


Analytical, diagnostic and therapeutic context of KIRREL2

  • The expression of NLG1 mRNA in kidney glomeruli was verified with RT-PCR [2].


  1. Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets. Sun, C., Kilburn, D., Lukashin, A., Crowell, T., Gardner, H., Brundiers, R., Diefenbach, B., Carulli, J.P. Genomics (2003) [Pubmed]
  2. Filtrin is a novel member of nephrin-like proteins. Ihalmo, P., Palmén, T., Ahola, H., Valtonen, E., Holthöfer, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes. Rinta-Valkama, J., Aaltonen, P., Lassila, M., Palmén, T., Tossavainen, P., Knip, M., Holthöfer, H. Diabetes Metab. Res. Rev. (2007) [Pubmed]
  4. Podocyte-associated proteins FAT, alpha-actinin-4 and filtrin are expressed in Langerhans islets of the pancreas. Rinta-Valkama, J., Palmén, T., Lassila, M., Holthöfer, H. Mol. Cell. Biochem. (2007) [Pubmed]
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