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Gene Review

Idh1  -  isocitrate dehydrogenase 1 (NADP+), soluble

Rattus norvegicus

Synonyms: Cytosolic NADP-isocitrate dehydrogenase, IDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase
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Disease relevance of Idh1


High impact information on Idh1

  • The oxidation of isocitrate through IDH activity was coupled to the cytochrome system by NADPH- and NADH-cytochrome c reductase activities [2].
  • The results suggest that the accumulation of high prostate citrate levels is not due to a limitation imposed by a lack of IDH activity in prostate mitochondria [2].


  1. Histochemistry of oxidative enzymes in experimental allergic encephalomyelitis. Wender, M., Kozik, M., Goncerzewicz, A. Folia histochemica et cytochemica. (1976) [Pubmed]
  2. Mitochondrial isocitrate dehydrogenase and isocitrate oxidation of rat ventral prostate. Costello, L.C., Franklin, R., Stacey, R. Enzyme (1976) [Pubmed]
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