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Gene Review

IDH1  -  isocitrate dehydrogenase 1 (NADP+), soluble

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High impact information on IDH1

  • In addition, we found that the trans-10, cis-12 CLA, but not the cis-9, trans-11 CLA isomer, inhibited basal- and PRL-induced IDH1 mRNA expression [1].
  • We propose that the inhibitory effects of CLA on milk fat synthesis in mammary epithelial cells may derive, at least in part, from repression of IDH1 expression [1].
  • In previous studies, we documented that the expression of IDH1 in bovine mammary epithelium was modulated by regulators of mammary differentiation and metabolic effectors [1].
  • The cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDH1) plays a critical role in cholesterol and fatty acid biosynthesis by providing reducing equivalents as NADPH [1].
  • Next, we examined the effects of extracellular matrix and lactogenic hormones on the expression of IDH1 in cultured BME-UV bovine mammary epithelial cells [2].

Biological context of IDH1

  • The enzymatic activity of IDH1 increases dramatically in early lactation in bovine mammary tissue [2].
  • IDH1 mRNA levels increased by 2.3-fold after parturition compared to late pregnancy and remained elevated thereafter [2].

Anatomical context of IDH1


Associations of IDH1 with chemical compounds


Other interactions of IDH1


Analytical, diagnostic and therapeutic context of IDH1

  • The inhibitory effects of the trans-10, cis-12 CLA isomer on PRL-induced IDH1 expression accumulation were confirmed by quantitative real time PCR and western-blotting analysis [1].


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