The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

IDH1  -  isocitrate dehydrogenase 1 (NADP+), soluble

Bos taurus

 
 
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on IDH1

  • In addition, we found that the trans-10, cis-12 CLA, but not the cis-9, trans-11 CLA isomer, inhibited basal- and PRL-induced IDH1 mRNA expression [1].
  • We propose that the inhibitory effects of CLA on milk fat synthesis in mammary epithelial cells may derive, at least in part, from repression of IDH1 expression [1].
  • In previous studies, we documented that the expression of IDH1 in bovine mammary epithelium was modulated by regulators of mammary differentiation and metabolic effectors [1].
  • The cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDH1) plays a critical role in cholesterol and fatty acid biosynthesis by providing reducing equivalents as NADPH [1].
  • Next, we examined the effects of extracellular matrix and lactogenic hormones on the expression of IDH1 in cultured BME-UV bovine mammary epithelial cells [2].
 

Biological context of IDH1

  • The enzymatic activity of IDH1 increases dramatically in early lactation in bovine mammary tissue [2].
  • IDH1 mRNA levels increased by 2.3-fold after parturition compared to late pregnancy and remained elevated thereafter [2].
 

Anatomical context of IDH1

 

Associations of IDH1 with chemical compounds

 

Other interactions of IDH1

 

Analytical, diagnostic and therapeutic context of IDH1

  • The inhibitory effects of the trans-10, cis-12 CLA isomer on PRL-induced IDH1 expression accumulation were confirmed by quantitative real time PCR and western-blotting analysis [1].

References

 
WikiGenes - Universities