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Gene Review

IDH1  -  isocitrate dehydrogenase 1 (NADP+), soluble

Homo sapiens

Synonyms: Cytosolic NADP-isocitrate dehydrogenase, HEL-216, HEL-S-26, IDCD, IDH, ...
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Disease relevance of IDH1


Psychiatry related information on IDH1

  • We studied 24 patients, 12 of whom had minor cognitive impairment or questionable dementia (PICD) and 12 who met NINCDS-ADRDA criteria for presenile AD (PAD) [5].

High impact information on IDH1

  • The presence of a human-specific enzyme identified by this method correlated with the presence of a particular human chromosome permitting assignments of the human cytoplasmic forms of NADP-linked IDH, human PGI, and human HGPRT genes to chromosomes 2, 19, and X, respectively [6].
  • The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase [7].
  • In subcellular fractionation experiments, we found PICD in both peroxisomes and cytoplasm of human and rat liver cells, with approximately 27% of total PICD protein associated with peroxisomes [7].
  • Kinetic studies on bacterially expressed PICD demonstrated that this enzyme catalyzed the oxidative decarboxylation of isocitrate to 2-oxoglutarate with a specific activity of 22.5 units/mg and that PICD displayed K(M) values of 76 microM for isocitrate and 112 microM for NADP(+) [7].
  • The presence of PICD in mammalian peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid [7].

Chemical compound and disease context of IDH1

  • Single crystals of monomeric IDH from Azotobacter vinelandii in complex with DL-isocitrate and Mn(2+) were obtained by the hanging-drop vapour-diffusion method at room temperature [8].

Biological context of IDH1

  • A series of rodent-human hybrid clones exhibiting a mitotic separation of IDH1 and MDH1 indicated that ADCP is most probably situated between corresponding loci in human chromosome 2 [9].
  • The prevalence of "isolated" systolic hypertension (ISH: "casual" blood pressure at or above 160 for systolic readings and below 95 for diastolic) was 6.2%, that of "isolated" diastolic (IDH) 9% and that of "simultaneous" systolic diastolic hypertension (SDH) 15.5% [10].

Anatomical context of IDH1

  • BACKGROUND: Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (IDH) is a chronic and recurrent eczema occurring during childhood and adolescence [11].

Associations of IDH1 with chemical compounds

  • Thus, in the present study the cross-cultural differences of IDH mortality are primarily attributable to plasma status of vitamin E, which might have protective functions [12].
  • The enzyme isocitrate dehydrogenase (IDH, EC can exhibit activation by one of its products, NADPH [13].
  • Mixing the tritopic ligand 2poap with pyridine-2,6-dicarboxylic acid (picd) in the presence of Cu(NO(3))(2) produces a remarkable mixed ligand, nonanuclear grid complex [Cu(9)(2poap-H)(4)(picd-H)(3)(picd-2H)](NO(3))(9).9H(2)O (7), in which aromatic pi-stacking interactions are important in stabilizing the structure [14].
  • One IDH, six ACP, six PER, and six EST isozymes were induced in cultured callus tissues in medium containing three 2,4-dichlorophenoxyacetic acid and kinetin combinations [15].

Other interactions of IDH1

  • The following markers and syntenic groups were localized : GUSB on PPA3 ; NP-MPI-PKM2-IDH2 on PPA7; ADA on PPA10 and IDH1 on PPA12 [16].
  • The fact that IDH1 and the MLC1F/MLC3F gene are closely linked on chromosome 1 in the mouse and map to the same region of human chromosome 2 in man indicates, that these chromosomes have a conserved region of homology between them and that the human 3.7-kb TaqI fragment corresponds indeed to a functional gene [17].
  • IDH-2 and human cytoplasmic IDH (IDH-1) were found to be asyntenic [18].
  • The analysis of six enzymatic systems showed the existence of four monomorphic systems (IDH, MDH, SHDH and SOD) [19].

Analytical, diagnostic and therapeutic context of IDH1

  • Serotypes of A. actinomycetemcomitans were determined by an indirect immunofluorescence assay using serotype-specific polyclonal antisera to A. actinomycetemcomitans strains ATCC 29523, ATCC 43728, ATCC 33384, IDH 781 and IDH 1705 (serotype a, b, c, d, and e, respectively) [20].
  • Pediatric surgeons should increase awareness regarding IDH in order to reduce delay in diagnosis and the need for surgical decompression [21].
  • The current epidemiological studies are done by different methods, and use non-standardized terminology with very free interpretation of the IDH concepts [22].
  • Increased body mass index (BMI) during follow-up predicted new-onset IDH and SDH [23].
  • This epidemic predominantly affected the adult population of Calcutta as evidenced by the hospitalization of more adults at the Infectious Disease Hospital, Calcutta (IDH), which bore the main brunt of the epidemic in and around Calcutta. During the peak of the epidemic about 180 to 300 diarrhoea patients were admitted daily at the IDH [24].


  1. LOH at 16p13 is a novel chromosomal alteration detected in benign and malignant microdissected papillary neoplasms of the breast. Lininger, R.A., Park, W.S., Man, Y.G., Pham, T., MacGrogan, G., Zhuang, Z., Tavassoli, F.A. Hum. Pathol. (1998) [Pubmed]
  2. Ductal carcinoma in situ: introduction of the concept of ductal intraepithelial neoplasia. Tavassoli, F.A. Mod. Pathol. (1998) [Pubmed]
  3. Systolic and diastolic hypertension: no relationship with lipid and inflammatory markers in Haute-Garonne, France. Marques-Vidal, P., Cambou, J.P., Bongard, V., Ruidavets, J.B., Ferrières, J. Am. J. Hypertens. (2003) [Pubmed]
  4. IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. van den Bent, M.J., Dubbink, H.J., Marie, Y., Brandes, A.A., Taphoorn, M.J., Wesseling, P., Frenay, M., Tijssen, C.C., Lacombe, D., Idbaih, A., van Marion, R., Kros, J.M., Dinjens, W.N., Gorlia, T., Sanson, M. Clin. Cancer Res. (2010) [Pubmed]
  5. Presenile primary cognitive decline or Alzheimer's dementia: 7-year clinical and neuropsychological follow-up. Zappoli, R., Paganini, M., Arnetoli, G., Bracco, L., Battaglia, A., Chiaramonti, R., Arneodo, M.G. Italian journal of neurological sciences. (1999) [Pubmed]
  6. Immunochemical detection of human enzymes in hybrid cells. Shimizu, N., Shimizu, Y., Kucherlapati, R.S., Ruddle, F.H. Cell (1976) [Pubmed]
  7. The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. Geisbrecht, B.V., Gould, S.J. J. Biol. Chem. (1999) [Pubmed]
  8. Crystallization and preliminary X-ray diffraction studies of monomeric isocitrate dehydrogenase by the MAD method using Mn atoms. Yasutake, Y., Watanabe, S., Yao, M., Takada, Y., Fukunaga, N., Tanaka, I. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  9. Assignment of adenosine deaminase complexing protein (ADCP) gene(s) to human chromosome 2 in rodent-human somatic cell hybrids. Herbschleb-Voogt, E., Grzeschik, K.H., Pearson, P.L., Meera Khan, P. Hum. Genet. (1981) [Pubmed]
  10. Isolated systolic hypertension in the community. Data from a population survey and hypertension register in Northern Italy. Ambrosio, G.B., Zamboni, S., Pilotto, L., Dal Palù, C. Clinical and experimental hypertension. Part A, Theory and practice. (1982) [Pubmed]
  11. Infective dermatitis and human T cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis in childhood and adolescence. Primo, J.R., Brites, C., Oliveira, M.d.e. .F., Moreno-Carvalho, O., Machado, M., Bittencourt, A.L. Clin. Infect. Dis. (2005) [Pubmed]
  12. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Gey, K.F., Puska, P., Jordan, P., Moser, U.K. Am. J. Clin. Nutr. (1991) [Pubmed]
  13. Bistability in the isocitrate dehydrogenase reaction: an experimentally based theoretical study. Guidi, G.M., Carlier, M.F., Goldbeter, A. Biophys. J. (1998) [Pubmed]
  14. Octanuclear and nonanuclear supramolecular copper(II) complexes with linear "tritopic" ligands: structural and magnetic studies. Milway, V.A., Niel, V., Abedin, T.S., Xu, Z., Thompson, L.K., Grove, H., Miller, D.O., Parsons, S.R. Inorganic chemistry. (2004) [Pubmed]
  15. Isozyme patterns in callus cultures and in plants regenerated from calli of Cereus peruvianus (Cactaceae). Mangolin, C.A., Prioli, A.J., Machado, M.F. Biochem. Genet. (1994) [Pubmed]
  16. Comparative gene mapping of the baboon (Papio papio) and man. Créau-Goldberg, N., Turleau, C., Cochet, C., de Grouchy, J. Ann. Genet. (1982) [Pubmed]
  17. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. Cohen-Haguenauer, O., Barton, P.J., Nguyen, V.C., Serero, S., Gross, M.S., Jegou-Foubert, C., de Tand, M.F., Robert, B., Buckingham, M., Frézal, J. Hum. Genet. (1988) [Pubmed]
  18. Somatic cell genetic assignment of the human gene for mitochondrial NADP-linked isocitrate dehydrogenase to the long arm of chromosome 15. Shimizu, N., Giles, R.E., Kucherlapati, R.S., Shimizu, Y., Ruddle, F.H. Somatic Cell Genet. (1977) [Pubmed]
  19. Polyporus s. str. in southern South America: isoenzyme analysis. Borges da Silveira, R.M., Saidman, B.O., Wright, J.E. Mycol. Res. (2003) [Pubmed]
  20. Relationship of Actinobacillus actinomycetemcomitans serotype b to aggressive periodontitis: frequency in pure cultured isolates. Yang, H.W., Asikainen, S., Doğan, B., Suda, R., Lai, C.H. J. Periodontol. (2004) [Pubmed]
  21. Post-traumatic intramural duodenal hematoma in children. Iuchtman, M., Steiner, T., Faierman, T., Breitgand, A., Bartal, G. Isr. Med. Assoc. J. (2006) [Pubmed]
  22. Epidemiology of disability and implications for practice. Hermanova, H.M. Public health reviews. (1993) [Pubmed]
  23. Predictors of new-onset diastolic and systolic hypertension: the Framingham Heart Study. Franklin, S.S., Pio, J.R., Wong, N.D., Larson, M.G., Leip, E.P., Vasan, R.S., Levy, D. Circulation (2005) [Pubmed]
  24. Epidemic of Vibrio cholerae 0139 in Calcutta. Bhattacharya, S.K., Goswami, A.G., Bhattacharya, M.K., Dutta, D., Deb, A., Deb, M., Sircar, B.K., Chowdhury, A.S., Das, K.P., Nair, G.B. Indian J. Med. Res. (1994) [Pubmed]
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