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Gene Review

Ldhb  -  lactate dehydrogenase B

Rattus norvegicus

Synonyms: L-lactate dehydrogenase B chain, LDH heart subunit, LDH-B, LDH-H, Ldh-2, ...
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Disease relevance of Ldhb


High impact information on Ldhb

  • Three fish LDH-As, as well as a single LDH of lamprey, also seem to be more related to vertebrate LDH-B than to land vertebrate LDH-A [2].
  • Polymorphism of lactate dehydrogenase B subunit in rat erythrocytes [3].
  • LDH B remained fairly constant, and LDH C increased from undetectable levels at birth to become the most abundant of the three polypeptides from week 3 onwards [4].

Biological context of Ldhb


Anatomical context of Ldhb

  • The mammalian LDH-C (testis) subunit appears to have diverged very early, prior to the divergence of vertebrate LDH-A and LDH-B subunits, as reported previously [2].
  • However, neither LDH-A or LDH-B mRNA abundance was affected following 3 days of hindlimb suspension [6].


  1. Expression of lactate dehydrogenase A and B genes in different tissues of rats adapted to chronic hypobaric hypoxia. Rossignol, F., Solares, M., Balanza, E., Coudert, J., Clottes, E. J. Cell. Biochem. (2003) [Pubmed]
  2. Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat. Tsuji, S., Qureshi, M.A., Hou, E.W., Fitch, W.M., Li, S.S. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Polymorphism of lactate dehydrogenase B subunit in rat erythrocytes. Stolc, V. Genet. Res. (1985) [Pubmed]
  4. Changes in testicular lactate dehydrogenases of the rat (Rattus norvegicus) during growth and development. Skidmore, A.F., Beebee, T.J. Comp. Biochem. Physiol., B (1991) [Pubmed]
  5. Effect of intermittent high altitude hypoxia on gene expression in rat heart and lung. Deindl, E., Kolár, F., Neubauer, E., Vogel, S., Schaper, W., Ostádal, B. Physiological research / Academia Scientiarum Bohemoslovaca. (2003) [Pubmed]
  6. Lactate dehydrogenase expression at the onset of altered loading in rat soleus muscle. Washington, T.A., Reecy, J.M., Thompson, R.W., Lowe, L.L., McClung, J.M., Carson, J.A. J. Appl. Physiol. (2004) [Pubmed]
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