Disease relevance of Ldhb

• Furthermore, chronic hypoxia limits LDH B gene transcription or its mRNA stability in both soleus and EDL [1].

High impact information on Ldhb

• Three fish LDH-As, as well as a single LDH of lamprey, also seem to be more related to vertebrate LDH-B than to land vertebrate LDH-A [2].
• Polymorphism of lactate dehydrogenase B subunit in rat erythrocytes [3].
• LDH B remained fairly constant, and LDH C increased from undetectable levels at birth to become the most abundant of the three polypeptides from week 3 onwards [4].

Biological context of Ldhb

• Lactate dehydrogenase (LDH) is a tetramer made up of two different subunits A and B. In cellular models, severe hypoxia increases LDH A gene expression whereas LDH B gene does not exhibit any regulation [1].
• For lactate dehydrogenase-A, we found a significant up-regulation in the RV and the lung, for lactate dehydrogenase-B up-regulation in the RV, but down-regulation in the LV and the atria [5].

Anatomical context of Ldhb

• The mammalian LDH-C (testis) subunit appears to have diverged very early, prior to the divergence of vertebrate LDH-A and LDH-B subunits, as reported previously [2].
• However, neither LDH-A or LDH-B mRNA abundance was affected following 3 days of hindlimb suspension [6].

References