The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

LDHB  -  lactate dehydrogenase B

Gallus gallus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of LDHB

  • These data demonstrate that LDH-B gene repression after hypoxia and reactivation after oxygen reperfusion occurs in both vascular and avascular retinal cells [1].
 

High impact information on LDHB

  • Lactate dehydrogenase (LDH) isoenzymes, LDH-A and LDH-B, are expressed in premeiotic, meiotic cells, and early spermatids, both in avian and mammalian spermatogenesis [2].
  • While mammals and columbid birds express the testis specific LDH-C gene in meiotic and postmeiotic cells, several LDH-B testis specific transcripts were detected in the corresponding cells during chicken spermatogenesis [2].
  • In developing chick retina in situ hybridization localized LDH-B mRNA to aerobic regions of the retina, coincident with the distribution of active mitochondria [1].
  • The three crystallins, alpha B-crystallin, tau-crystallin/alpha-enolase and epsilon-crystallin/lactate dehydrogenase B are all stress induced proteins and may thus share common regulatory elements [3].
  • This species-specific difference may correlate with the difference in LDH-B activity between various chicken and duck tissues: the retina and pancreas in duck have significantly higher LDH-B activity than in chick, while heart, muscle, stomach, liver, intestine and kidney all have much higher LDH-B activity in chicken than in duck [3].
 

Anatomical context of LDHB

  • These observations suggest that GB expressed only LDH-B and that GB cells are not lactate-producing cells, like astrocyte, but rather are lactate-consuming cells, similar to neurons in CNS [4].
  • In the GB the subtype of LDH mRNA was LDM-B only, and in the cerebral cortex and spinal cord, the subtype of LDH mRNA was predominantly LDH-B, and a small amount of LDH-A was found in the chicken and embryo [4].
 

Analytical, diagnostic and therapeutic context of LDHB

  • Northern and semi-quantitative RT/PCR analyses demonstrated that LDH-B mRNA levels decrease in primary rat and chick retinal cells in response to hypoxia [1].

References

  1. Hypoxic repression of lactate dehydrogenase-B in retina. Buono, R.J., Lang, R.K. Exp. Eye Res. (1999) [Pubmed]
  2. Expression of lactate dehydrogenases A and B during chicken spermatogenesis: characterization of testis specific transcripts. Arias, W.M., Mezquita, C., Mezquita, J. J. Cell. Biochem. (2000) [Pubmed]
  3. The developmental expression of taxon-specific crystallins in the duck lens. Kraft, H.J., Voorter, C.E., Wintjes, L., Lubsen, N.H., Schoenmakers, J.G. Exp. Eye Res. (1994) [Pubmed]
  4. Expression of lactate dehydrogenase-A and -B messenger ribonucleic acids in chick glycogen body. Imagawa, T., Yamamoto, E., Sawada, M., Okamoto, M., Uehara, M. Poult. Sci. (2006) [Pubmed]
 
WikiGenes - Universities