Disease relevance of Igf2r

• These results suggest that alterations of the M6p/Igf2r gene may be involved in the development of lung adenocarcinomas induced by BHP in rats [1].
• To elucidate whether the M6p/Igf2 receptor (M6p/Igf2r) gene might be involved in exogenous and endogenous liver carcinogenesis, we investigated its alteration in hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) and by a choline-deficient L-amino acid-defined (CDAA) diet in rats [2].

High impact information on Igf2r

• Furthermore, O6-methylguanine DNA methyltransferase and mannose 6-phosphatase/insulin-like growth factor 2 receptor mRNA levels were quantified [3].
• Total RNA was extracted from individual HCCs for assessment of mutations within exons 27, 28, 31, 33, and 34, and aberrant transcript of the M6p/Igf2r gene by reverse transcription (RT)-polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) and RT-PCR analyses, respectively [2].
• A total of 12 lung adenocarcinomas were obtained, and total RNAs were extracted from each for assessment of mutations and levels of aberrant transcripts of the M6p/Igf2r gene by reverse transcription (RT)-polymerase chain reaction (PCR) single-strand conformation polymorphism analysis and RT-PCR analysis, respectively [1].
• It was supposed that mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R), at least in part, activates TGF-beta preproprotein [4].
• In the present study, we examined the polymorphism in mannose 6-phosphate/insulin-like growth factor 2 receptor (M6p/Igf2r) gene and found that the DRH rat showed CCC (Proline)-type polymorphism in exon 48 and the Donryu rat had GCC (Alanine) sequence [5].

References