Gene Review:
Igf2r - insulin-like growth factor 2 receptor
Mus musculus
Synonyms:
300 kDa mannose 6-phosphate receptor, AI661837, CD222, CI Man-6-P receptor, CI-MPR, ...
- Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements. Pauler, F.M., Stricker, S.H., Warczok, K.E., Barlow, D.P. Genome Res. (2005)
- Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice. Wutz, A., Theussl, H.C., Dausman, J., Jaenisch, R., Barlow, D.P., Wagner, E.F. Development (2001)
- Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Ludwig, T., Eggenschwiler, J., Fisher, P., D'Ercole, A.J., Davenport, M.L., Efstratiadis, A. Dev. Biol. (1996)
- Foreign DNA integration. Genome-wide perturbations of methylation and transcription in the recipient genomes. Müller, K., Heller, H., Doerfler, W. J. Biol. Chem. (2001)
- Trans allele methylation and paramutation-like effects in mice. Herman, H., Lu, M., Anggraini, M., Sikora, A., Chang, Y., Yoon, B.J., Soloway, P.D. Nat. Genet. (2003)
- Parental imprinting of the Mas protooncogene in mouse. Villar, A.J., Pedersen, R.A. Nat. Genet. (1994)
- Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Stöger, R., Kubicka, P., Liu, C.G., Kafri, T., Razin, A., Cedar, H., Barlow, D.P. Cell (1993)
- Genetic analysis of genomic imprinting: an Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locus. Forejt, J., Gregorová, S. Cell (1992)
- The imprinting box of the mouse Igf2r gene. Birger, Y., Shemer, R., Perk, J., Razin, A. Nature (1999)
- Insulin-like growth factor II inhibits glucose-induced insulin exocytosis. Zhang, Q., Berggren, P.O., Larsson, O., Hall, K., Tally, M. Biochem. Biophys. Res. Commun. (1998)
- Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor? Dabrosin, C., Johansson, A.C., Ollinger, K. Breast Cancer Res. Treat. (2004)
- Imprinted expression of the Igf2r gene depends on an intronic CpG island. Wutz, A., Smrzka, O.W., Schweifer, N., Schellander, K., Wagner, E.F., Barlow, D.P. Nature (1997)
- Igf2r and Igf2 gene expression in androgenetic, gynogenetic, and parthenogenetic preimplantation mouse embryos: absence of regulation by genomic imprinting. Latham, K.E., Doherty, A.S., Scott, C.D., Schultz, R.M. Genes Dev. (1994)
- Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms. Szabó, P.E., Mann, J.R. Genes Dev. (1995)
- Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air. Yamasaki, Y., Kayashima, T., Soejima, H., Kinoshita, A., Yoshiura, K., Matsumoto, N., Ohta, T., Urano, T., Masuzaki, H., Ishimaru, T., Mukai, T., Niikawa, N., Kishino, T. Hum. Mol. Genet. (2005)
- Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis. Obata, Y., Kaneko-Ishino, T., Koide, T., Takai, Y., Ueda, T., Domeki, I., Shiroishi, T., Ishino, F., Kono, T. Development (1998)
- A functional analysis of imprinting in parthenogenetic embryonic stem cells. Allen, N.D., Barton, S.C., Hilton, K., Norris, M.L., Surani, M.A. Development (1994)
- Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene. Schweifer, N., Valk, P.J., Delwel, R., Cox, R., Francis, F., Meier-Ewert, S., Lehrach, H., Barlow, D.P. Genomics (1997)
- Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Lau, M.M., Stewart, C.E., Liu, Z., Bhatt, H., Rotwein, P., Stewart, C.L. Genes Dev. (1994)
- Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo. Lerchner, W., Barlow, D.P. Mech. Dev. (1997)
- Imprinted M6p/Igf2 receptor is mutated in rat liver tumors. Mills, J.J., Falls, J.G., De Souza, A.T., Jirtle, R.L. Oncogene (1998)
- Ligand binding specificities of the two mannose 6-phosphate receptors. Sleat, D.E., Lobel, P. J. Biol. Chem. (1997)
- Mannose-6-phosphate enhances cross-linking efficiency between insulin-like growth factor-II (IGF-II) and IGF-II/mannose-6-phosphate receptors in membranes. MacDonald, R.G. Endocrinology (1991)
- Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes. Zwart, R., Sleutels, F., Wutz, A., Schinkel, A.H., Barlow, D.P. Genes Dev. (2001)
- Allele-specific histone acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene. Hu, J.F., Pham, J., Dey, I., Li, T., Vu, T.H., Hoffman, A.R. Endocrinology (2000)
- An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias. Latos, P.A., Stricker, S.H., Steenpass, L., Pauler, F.M., Huang, R., Senergin, B.H., Regha, K., Koerner, M.V., Warczok, K.E., Unger, C., Barlow, D.P. Development (2009)
- The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Barlow, D.P., Stöger, R., Herrmann, B.G., Saito, K., Schweifer, N. Nature (1991)
- Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes. Dean, W., Bowden, L., Aitchison, A., Klose, J., Moore, T., Meneses, J.J., Reik, W., Feil, R. Development (1998)
- Disruption of imprinting in cloned mouse fetuses from embryonic stem cells. Ogawa, H., Ono, Y., Shimozawa, N., Sotomaru, Y., Katsuzawa, Y., Hiura, H., Ito, M., Kono, T. Reproduction (2003)
- The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms. Zaina, S., Squire, S. J. Biol. Chem. (1998)
- Serum factors alter the extent of dephosphorylation of ligands endocytosed via the mannose 6-phosphate/insulin-like growth factor II receptor. Einstein, R., Gabel, C.A. J. Cell Biol. (1989)
- Insulin-like growth factor II may play a local role in the regulation of ocular size. Cuthbertson, R.A., Beck, F., Senior, P.V., Haralambidis, J., Penschow, J.D., Coghlan, J.P. Development (1989)
- Cellular response to latent TGF-beta1 is facilitated by insulin-like growth factor-II/mannose-6-phosphate receptors on MS-9 cells. Ghahary, A., Tredget, E.E., Mi, L., Yang, L. Exp. Cell Res. (1999)
- Endocytosed cation-independent mannose 6-phosphate receptor traffics via the endocytic recycling compartment en route to the trans-Golgi network and a subpopulation of late endosomes. Lin, S.X., Mallet, W.G., Huang, A.Y., Maxfield, F.R. Mol. Biol. Cell (2004)