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Gene Review:

Gstt1 - glutathione S-transferase theta 1

Rattus norvegicus

Synonyms: GST 5-5, GST class-theta-1, Glutathione S-transferase 5, Glutathione S-transferase theta-1

Shimada, T. et al., Marsch, G.A. et al., Guengerich, F.P. et al., Brambila, E. et al., Gisi, D. et al.

Guengerich, McCormick, Wheeler,

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High impact information on Gstt1

The four DNA nucleosides were also reacted with the dihalomethanes CH(2)Cl(2) and CH(2)Br(2) in the presence of glutathione (GSH) and GSH S-transferases from bacteria (DM11), rat (GST 5-5), and human (GST T1-1) under conditions that produce mutations in bacteria [1].
We examined rat GST 5-5 and human GST T1-1 and did not detect any burst kinetics in the conjugation of C(2)H(5)Cl, CH(2)Br(2), or CH(2)Cl(2), distinguishing these enzymes from GST DM11 [2].
1,2-Epoxy-3-(4'-nitrophenoxy)propane and 2,3-dibromo-1-chloropropane were inactivated by GST 5-5 in the NM5004 tester strain, although these chemicals were cytotoxic in both tester strains [3].
Roles of GST 5-5 were also examined for the inactivation of reactive metabolites of several procarcinogens that were formed through oxidation by liver microsomes of polychlorinated biphenyl-treated rats [3].
Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants [4].

Biological context of Gstt1

Microarray analysis revealed a significant upregulation in the renal expression of the GST-pi, GST-Ya, and microsomal GST and GST5-5 genes in nonpregnant and pregnant rats [5].

References

Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathione S-transferase-mediated activation of dihalomethanes. Marsch, G.A., Botta, S., Martin, M.V., McCormick, W.A., Guengerich, F.P. Chem. Res. Toxicol. (2004) [Pubmed]
Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. Guengerich, F.P., McCormick, W.A., Wheeler, J.B. Chem. Res. Toxicol. (2003) [Pubmed]
Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004. Shimada, T., Yamazaki, H., Oda, Y., Hiratsuka, A., Watabe, T., Guengerich, F.P. Chem. Res. Toxicol. (1996) [Pubmed]
Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants. Gisi, D., Maillard, J., Flanagan, J.U., Rossjohn, J., Chelvanayagam, G., Board, P.G., Parker, M.W., Leisinger, T., Vuilleumier, S. Eur. J. Biochem. (2001) [Pubmed]
Effect of mercury vapor exposure on metallothionein and glutathione s-transferase gene expression in the kidney of nonpregnant, pregnant, and neonatal rats. Brambila, E., Liu, J., Morgan, D.L., Beliles, R.P., Waalkes, M.P. J. Toxicol. Environ. Health Part A (2002) [Pubmed]

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