Disease relevance of FVT1

• FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma [1].

High impact information on FVT1

• These and other data suggest that genes at 18q21.3, other than BCL2 and FVT1, may be targets for translocation in certain subgroups of B-NHL [2].
• The FVT-1 gene is weakly expressed in all the analyzed normal hematopoietic tissues but a very high rate of transcription is observed in some T-cell malignancies and in phytohemagglutinin-stimulated lymphocytes [1].
• Immunofluorescence microscopic analysis revealed that hFVT-1 is localized at the endoplasmic reticulum [3].
• FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane [3].
• Moreover, purified recombinant hFVT-1 protein exhibited NADPH-dependent KDS reductase activity [3].

Anatomical context of FVT1

• Moreover, a proteinase K digestion assay revealed that the large hydrophilic domain of hFVT-1, which contains putative active site residues, faces the cytosol [3].

Associations of FVT1 with chemical compounds

• Their synthesis is initiated with the condensation of l-serine with palmitoyl-CoA, producing 3-ketodihydrosphingosine (KDS), followed by a reduction to dihydrosphingosine by KDS reductase [3].

Analytical, diagnostic and therapeutic context of FVT1

• Northern blot analyses demonstrated that both hFVT-1 and mFVT-1 mRNAs are ubiquitously expressed, suggesting that FVT-1 is a major KDS reductase [3].

References