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Gene Review

GABRA5  -  gamma-aminobutyric acid (GABA) A receptor,...

Homo sapiens

Synonyms: GABA(A) receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-5
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Disease relevance of GABRA5


Psychiatry related information on GABRA5


High impact information on GABRA5

  • We report a 50-60 kb domain of allele-specific replication between the gamma-aminobutyric acid receptor subunit beta 3 (GABRB3) and alpha 5 (GABRA5) genes [8].
  • The two loci, GABRA5 and D15S24, flanking D15S12, are both hypervariable, and many different haplotypes were observed with the alleles at the three loci on both ty-pos OCA-associated chromosomes and "normal" chromosomes.(ABSTRACT TRUNCATED AT 250 WORDS)[9]
  • GABRB3 encompasses approximately 250 kb, while GABRA5 is contained within 70 kb [10].
  • Moreover, we have found replication asynchrony across the GABRA5 duplication, suggesting for the first time that the imprinted part of chromosome 15q extends proximal of the region commonly deleted in Angelman and Prader-Willi syndromes [11].
  • GABRB3 spans 250 kb of DNA and is organized into 9 exons that range from 68 to 504 bp, while GABRA5 is encoded by 11 exons (65 to 924 bp in length) within 86 kb [2].

Biological context of GABRA5


Anatomical context of GABRA5

  • Several genes/transcripts (for example, GABRA5, GABRB3) had increased expression in UPD cell lines compared with deletion, but less than controls indicating paternal bias [13].

Other interactions of GABRA5


Analytical, diagnostic and therapeutic context of GABRA5


  1. FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions. Knoll, J.H., Sinnett, D., Wagstaff, J., Glatt, K., Wilcox, A.S., Whiting, P.M., Wingrove, P., Sikela, J.M., Lalande, M. Hum. Mol. Genet. (1993) [Pubmed]
  2. Structure and organization of GABRB3 and GABRA5. Glatt, K., Glatt, H., Lalande, M. Genomics (1997) [Pubmed]
  3. The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. Greger, V., Knoll, J.H., Woolf, E., Glatt, K., Tyndale, R.F., DeLorey, T.M., Olsen, R.W., Tobin, A.J., Sikela, J.M., Nakatsu, Y. Genomics (1995) [Pubmed]
  4. Duplication of the 15q11-13 region in a patient with autism, epilepsy and ataxia. Bundey, S., Hardy, C., Vickers, S., Kilpatrick, M.W., Corbett, J.A. Developmental medicine and child neurology. (1994) [Pubmed]
  5. The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder. Otani, K., Ujike, H., Tanaka, Y., Morita, Y., Katsu, T., Nomura, A., Uchida, N., Hamamura, T., Fujiwara, Y., Kuroda, S. Neurosci. Lett. (2005) [Pubmed]
  6. Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder. Menold, M.M., Shao, Y., Wolpert, C.M., Donnelly, S.L., Raiford, K.L., Martin, E.R., Ravan, S.A., Abramson, R.K., Wright, H.H., Delong, G.R., Cuccaro, M.L., Pericak-Vance, M.A., Gilbert, J.R. J. Neurogenet. (2001) [Pubmed]
  7. Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder. Papadimitriou, G.N., Dikeos, D.G., Karadima, G., Avramopoulos, D., Daskalopoulou, E.G., Vassilopoulos, D., Stefanis, C.N. Am. J. Med. Genet. (1998) [Pubmed]
  8. Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental 15q11-13 contribution. LaSalle, J.M., Lalande, M. Nat. Genet. (1995) [Pubmed]
  9. The tyrosinase-positive oculocutaneous albinism gene shows locus homogeneity on chromosome 15q11-q13 and evidence of multiple mutations in southern African negroids. Kedda, M.A., Stevens, G., Manga, P., Viljoen, C., Jenkins, T., Ramsay, M. Am. J. Hum. Genet. (1994) [Pubmed]
  10. High-resolution mapping of the gamma-aminobutyric acid receptor subunit beta 3 and alpha 5 gene cluster on chromosome 15q11-q13, and localization of breakpoints in two Angelman syndrome patients. Sinnett, D., Wagstaff, J., Glatt, K., Woolf, E., Kirkness, E.J., Lalande, M. Am. J. Hum. Genet. (1993) [Pubmed]
  11. A large polymorphic repeat in the pericentromeric region of human chromosome 15q contains three partial gene duplications. Ritchie, R.J., Mattei, M.G., Lalande, M. Hum. Mol. Genet. (1998) [Pubmed]
  12. Human gamma-aminobutyric acid-type A receptor alpha5 subunit gene (GABRA5): characterization and structural organization of the 5' flanking region. Kim, Y., Glatt, H., Xie, W., Sinnett, D., Lalande, M. Genomics (1997) [Pubmed]
  13. Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD. Bittel, D.C., Kibiryeva, N., Talebizadeh, Z., Butler, M.G. J. Med. Genet. (2003) [Pubmed]
  14. Organisation of the pericentromeric region of chromosome 15: at least four partial gene copies are amplified in patients with a proximal duplication of 15q. Fantes, J.A., Mewborn, S.K., Lese, C.M., Hedrick, J., Brown, R.L., Dyomin, V., Chaganti, R.S., Christian, S.L., Ledbetter, D.H. J. Med. Genet. (2002) [Pubmed]
  15. Lack of association between juvenile myoclonic epilepsy and GABRA5 and GABRB3 genes. Guipponi, M., Thomas, P., Girard-Reydet, C., Feingold, J., Baldy-Moulinier, M., Malafosse, A. Am. J. Med. Genet. (1997) [Pubmed]
  16. Possible association between childhood absence epilepsy and the gene encoding GABRB3. Feucht, M., Fuchs, K., Pichlbauer, E., Hornik, K., Scharfetter, J., Goessler, R., Füreder, T., Cvetkovic, N., Sieghart, W., Kasper, S., Aschauer, H. Biol. Psychiatry (1999) [Pubmed]
  17. Case-control study and transmission/disequilibrium tests of the genes encoding GABRA5 and GABRB3 in a Chinese population affected by childhood absence epilepsy. Lü, J.J., Zhang, Y.H., Pan, H., Chen, Y.C., Liu, X.Y., Jiang, Y.W., Bao, X.H., Shen, Y., Wu, H.S., Xu, K.M., Wu, X.R. Chin. Med. J. (2004) [Pubmed]
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