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Gene Review

GABRG3  -  gamma-aminobutyric acid (GABA) A receptor,...

Homo sapiens

Synonyms: GABA(A) receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit gamma-3
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Disease relevance of GABRG3

  • Lambda and P1 phage clones surrounding both ends of GABRG3 were isolated; the clones derived from the 5' end of GABRG3 were linked to an existing phage contig spanning the 3' end of GABRA5 [1].

Psychiatry related information on GABRG3


High impact information on GABRG3


Biological context of GABRG3


  1. The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. Greger, V., Knoll, J.H., Woolf, E., Glatt, K., Tyndale, R.F., DeLorey, T.M., Olsen, R.W., Tobin, A.J., Sikela, J.M., Nakatsu, Y. Genomics (1995) [Pubmed]
  2. Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder. Menold, M.M., Shao, Y., Wolpert, C.M., Donnelly, S.L., Raiford, K.L., Martin, E.R., Ravan, S.A., Abramson, R.K., Wright, H.H., Delong, G.R., Cuccaro, M.L., Pericak-Vance, M.A., Gilbert, J.R. J. Neurogenet. (2001) [Pubmed]
  3. An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder. Ashley-Koch, A.E., Mei, H., Jaworski, J., Ma, D.Q., Ritchie, M.D., Menold, M.M., Delong, G.R., Abramson, R.K., Wright, H.H., Hussman, J.P., Cuccaro, M.L., Gilbert, J.R., Martin, E.R., Pericak-Vance, M.A. Ann. Hum. Genet. (2006) [Pubmed]
  4. Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12). Gole, L., Crolla, J.A., Thomas, S.N., Jacobs, P.A., Dennis, N.R. Am. J. Med. Genet. A (2004) [Pubmed]
  5. Association of GABRG3 with alcohol dependence. Dick, D.M., Edenberg, H.J., Xuei, X., Goate, A., Kuperman, S., Schuckit, M., Crowe, R., Smith, T.L., Porjesz, B., Begleiter, H., Foroud, T. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
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