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MeSH Review

Autistic Disorder

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Disease relevance of Autistic Disorder


Psychiatry related information on Autistic Disorder


High impact information on Autistic Disorder


Chemical compound and disease context of Autistic Disorder


Biological context of Autistic Disorder


Anatomical context of Autistic Disorder


Gene context of Autistic Disorder

  • GFAP levels in children with infantile autism were higher than those in normal children of the same age range [29].
  • Six previous family-based association studies of SLC6A4 in autistic disorder have been conducted, with four studies showing nominally significant transmission disequilibrium and two studies with no evidence of nominally significant transmission disequilibrium [30].
  • Children with large RELN alleles did not show any difference in scores for questions related to the core symptoms of autistic disorder, but there was a tendency for children with at least one large RELN allele to have an earlier age at first phrase (chi(2) = 3.538, P = 0.06) [31].
  • Mutation analysis of the coding sequence of the MECP2 gene in infantile autism [32].
  • No association between the WNT2 gene and autistic disorder [23].

Analytical, diagnostic and therapeutic context of Autistic Disorder


  1. The effect of a switch to ziprasidone in an adult population with autistic disorder: chart review of naturalistic, open-label treatment. Cohen, S.A., Fitzgerald, B.J., Khan, S.R., Khan, A. The Journal of clinical psychiatry. (2004) [Pubmed]
  2. Oral dyskinesia induced by fluoxetine therapy for infantile autism. Albertini, G., Majolini, L., Di Gennaro, G., Quarato, P., Scoppetta, C., Onorati, P., Albertini, G., Majolini, L., Di Gennaro, G., Quarato, P., Scoppetta, C., Onorati, P., Albertini, G., Majolini, L., Di Gennaro, G., Quarato, P., Scoppetta, C., Onorati, P. Pediatric neurology. (2004) [Pubmed]
  3. Folic acid as an adjunct in the treatment of children with the autism fragile-X syndrome (AFRAX). Gillberg, C., Wahlström, J., Johansson, R., Törnblom, M., Albertsson-Wikland, K. Developmental medicine and child neurology. (1986) [Pubmed]
  4. Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder. Cook, E.H., Charak, D.A., Arida, J., Spohn, J.A., Roizen, N.J., Leventhal, B.L. Psychiatry research. (1994) [Pubmed]
  5. Elevated plasma gamma-aminobutyric acid (GABA) levels in autistic youngsters: stimulus for a GABA hypothesis of autism. Dhossche, D., Applegate, H., Abraham, A., Maertens, P., Bland, L., Bencsath, A., Martinez, J. Med. Sci. Monit. (2002) [Pubmed]
  6. Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology. McDougle, C.J., Scahill, L., Aman, M.G., McCracken, J.T., Tierney, E., Davies, M., Arnold, L.E., Posey, D.J., Martin, A., Ghuman, J.K., Shah, B., Chuang, S.Z., Swiezy, N.B., Gonzalez, N.M., Hollway, J., Koenig, K., McGough, J.J., Ritz, L., Vitiello, B. The American journal of psychiatry. (2005) [Pubmed]
  7. Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. Anderson, L.T., Campbell, M., Grega, D.M., Perry, R., Small, A.M., Green, W.H. The American journal of psychiatry. (1984) [Pubmed]
  8. Sertraline response in adults with mental retardation and autistic disorder. Hellings, J.A., Kelley, L.A., Gabrielli, W.F., Kilgore, E., Shah, P. The Journal of clinical psychiatry. (1996) [Pubmed]
  9. Sertraline in adults with pervasive developmental disorders: a prospective open-label investigation. McDougle, C.J., Brodkin, E.S., Naylor, S.T., Carlson, D.C., Cohen, D.J., Price, L.H. Journal of clinical psychopharmacology. (1998) [Pubmed]
  10. Fluvoxamine. An updated review of its use in the management of adults with anxiety disorders. Figgitt, D.P., McClellan, K.J. Drugs (2000) [Pubmed]
  11. A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. McDougle, C.J., Holmes, J.P., Carlson, D.C., Pelton, G.H., Cohen, D.J., Price, L.H. Arch. Gen. Psychiatry (1998) [Pubmed]
  12. Effects of tryptophan depletion in drug-free adults with autistic disorder. McDougle, C.J., Naylor, S.T., Cohen, D.J., Aghajanian, G.K., Heninger, G.R., Price, L.H. Arch. Gen. Psychiatry (1996) [Pubmed]
  13. A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. McDougle, C.J., Naylor, S.T., Cohen, D.J., Volkmar, F.R., Heninger, G.R., Price, L.H. Arch. Gen. Psychiatry (1996) [Pubmed]
  14. A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Gordon, C.T., State, R.C., Nelson, J.E., Hamburger, S.D., Rapoport, J.L. Arch. Gen. Psychiatry (1993) [Pubmed]
  15. Brain metabolism in autism. Resting cerebral glucose utilization rates as measured with positron emission tomography. Rumsey, J.M., Duara, R., Grady, C., Rapoport, J.L., Margolin, R.A., Rapoport, S.I., Cutler, N.R. Arch. Gen. Psychiatry (1985) [Pubmed]
  16. Association between a GABRB3 polymorphism and autism. Buxbaum, J.D., Silverman, J.M., Smith, C.J., Greenberg, D.A., Kilifarski, M., Reichert, J., Cook, E.H., Fang, Y., Song, C.Y., Vitale, R. Mol. Psychiatry (2002) [Pubmed]
  17. Fluorine magnetic resonance spectroscopy measurement of brain fluvoxamine and fluoxetine in pediatric patients treated for pervasive developmental disorders. Strauss, W.L., Unis, A.S., Cowan, C., Dawson, G., Dager, S.R. The American journal of psychiatry. (2002) [Pubmed]
  18. High blood monocyte counts and neopterin levels in children with autistic disorder. Sweeten, T.L., Posey, D.J., McDougle, C.J. The American journal of psychiatry. (2003) [Pubmed]
  19. A pilot study of D-cycloserine in subjects with autistic disorder. Posey, D.J., Kem, D.L., Swiezy, N.B., Sweeten, T.L., Wiegand, R.E., McDougle, C.J. The American journal of psychiatry. (2004) [Pubmed]
  20. Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers. Cook, E.H., Courchesne, R.Y., Cox, N.J., Lord, C., Gonen, D., Guter, S.J., Lincoln, A., Nix, K., Haas, R., Leventhal, B.L., Courchesne, E. Am. J. Hum. Genet. (1998) [Pubmed]
  21. Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Ramoz, N., Reichert, J.G., Smith, C.J., Silverman, J.M., Bespalova, I.N., Davis, K.L., Buxbaum, J.D. The American journal of psychiatry. (2004) [Pubmed]
  22. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Tordjman, S., Anderson, G.M., Pichard, N., Charbuy, H., Touitou, Y. Biol. Psychiatry (2005) [Pubmed]
  23. No association between the WNT2 gene and autistic disorder. McCoy, P.A., Shao, Y., Wolpert, C.M., Donnelly, S.L., Ashley-Koch, A., Abel, H.L., Ravan, S.A., Abramson, R.K., Wright, H.H., DeLong, G.R., Cuccaro, M.L., Gilbert, J.R., Pericak-Vance, M.A. Am. J. Med. Genet. (2002) [Pubmed]
  24. Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. Persico, A.M., Militerni, R., Bravaccio, C., Schneider, C., Melmed, R., Conciatori, M., Damiani, V., Baldi, A., Keller, F. Am. J. Med. Genet. (2000) [Pubmed]
  25. Anterior cingulate gyrus volume and glucose metabolism in autistic disorder. Haznedar, M.M., Buchsbaum, M.S., Metzger, M., Solimando, A., Spiegel-Cohen, J., Hollander, E. The American journal of psychiatry. (1997) [Pubmed]
  26. Cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid in autism. Narayan, M., Srinath, S., Anderson, G.M., Meundi, D.B. Biol. Psychiatry (1993) [Pubmed]
  27. Reassessment of elevated serotonin levels in blood platelets in early infantile autism. Takahashi, S., Kanai, H., Miyamoto, Y. Journal of autism and childhood schizophrenia. (1976) [Pubmed]
  28. Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network. Ozonoff, S., Cook, I., Coon, H., Dawson, G., Joseph, R.M., Klin, A., McMahon, W.M., Minshew, N., Munson, J.A., Pennington, B.F., Rogers, S.J., Spence, M.A., Tager-Flusberg, H., Volkmar, F.R., Wrathall, D. Journal of autism and developmental disorders. (2004) [Pubmed]
  29. A sensitive ELISA for glial fibrillary acidic protein: application in CSF of children. Rosengren, L.E., Ahlsén, G., Belfrage, M., Gillberg, C., Haglid, K.G., Hamberger, A. J. Neurosci. Methods (1992) [Pubmed]
  30. Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. Kim, S.J., Cox, N., Courchesne, R., Lord, C., Corsello, C., Akshoomoff, N., Guter, S., Leventhal, B.L., Courchesne, E., Cook, E.H. Mol. Psychiatry (2002) [Pubmed]
  31. Reelin gene alleles and susceptibility to autism spectrum disorders. Zhang, H., Liu, X., Zhang, C., Mundo, E., Macciardi, F., Grayson, D.R., Guidotti, A.R., Holden, J.J. Mol. Psychiatry (2002) [Pubmed]
  32. Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Beyer, K.S., Blasi, F., Bacchelli, E., Klauck, S.M., Maestrini, E., Poustka, A. Hum. Genet. (2002) [Pubmed]
  33. Functional deficits in autistic disorder: characterization by technetium-99m-HMPAO and SPECT. Mountz, J.M., Tolbert, L.C., Lill, D.W., Katholi, C.R., Liu, H.G. J. Nucl. Med. (1995) [Pubmed]
  34. Effects of fenfluramine on EEG and brainstem average evoked response in infantile autism. Preliminary investigation. Raz, N., Pritchard, W.S., August, G.J. Neuropsychobiology (1987) [Pubmed]
  35. Hypothesis: is infantile autism a hypoglutamatergic disorder? Relevance of glutamate - serotonin interactions for pharmacotherapy. Carlsson, M.L. Journal of neural transmission (Vienna, Austria : 1996) (1998) [Pubmed]
  36. Secretin treatment for autistic disorder: a critical analysis. Patel, N.C., Yeh, J.Y., Shepherd, M.D., Crismon, M.L. Pharmacotherapy (2002) [Pubmed]
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