High impact information on Ppard

• Peroxisome proliferator-activated receptor delta is up-regulated during vascular lesion formation and promotes post-confluent cell proliferation in vascular smooth muscle cells [1].
• Either was more effective than the combination of peroxisome proliferator-activated receptor gamma and alpha activation, suggesting that peroxisome proliferator-activated receptor delta is involved in this lipid formation [2].
• Linoleic acid and carbaprostacyclin, both peroxisome proliferator-activated receptor delta and alpha ligand-activators, were more effective but less specific, stimulating lipid formation in both types of cells [2].
• Placental expression of Ppara, Ppard, and Rxra was unaffected by dexamethasone treatment [3].
• The aim of this study was to examine the expression and regulation of peroxisome proliferator-activated receptor delta (PPARdelta) gene in rat uterus during early pregnancy by in situ hybridization and immunohistochemistry [4].

Biological context of Ppard

• Recent gene deletion studies indicate that PPARG and PPARD play critical roles in rodent development, including effects on placental vascularization [3].

Anatomical context of Ppard

• Differential expression of peroxisome proliferator-activated receptor delta at implantation sites and in decidual cells of rat uterus [4].

References