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Gene Review

PPARD  -  peroxisome proliferator-activated receptor...

Homo sapiens

Synonyms: FAAR, NR1C2, NUC1, NUCI, NUCII, ...
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Disease relevance of PPARD


Psychiatry related information on PPARD


High impact information on PPARD

  • PPARB was identified as a target of APC through the analysis of global gene expression profiles in human colorectal cancer (CRC) cells [7].
  • The three 'lipid-sensing' peroxisome proliferator-activated receptors (PPAR-alpha, PPAR-gamma and PPAR-delta) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets [8].
  • Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth [9].
  • The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm [9].
  • We treated Apc(min) mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-delta (PPAR-delta) [9].

Chemical compound and disease context of PPARD


Biological context of PPARD


Anatomical context of PPARD


Associations of PPARD with chemical compounds


Physical interactions of PPARD


Regulatory relationships of PPARD


Other interactions of PPARD


Analytical, diagnostic and therapeutic context of PPARD


  1. Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Chen, S., Tsybouleva, N., Ballantyne, C.M., Gotto, A.M., Marian, A.J. Pharmacogenetics (2004) [Pubmed]
  2. Peroxisome proliferator-activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects. Hu, C., Jia, W., Fang, Q., Zhang, R., Wang, C., Lu, J., Xiang, K. Diabet. Med. (2006) [Pubmed]
  3. Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. Tenenbaum, A., Motro, M., Fisman, E.Z. Cardiovascular diabetology [electronic resource]. (2005) [Pubmed]
  4. Genetic polymorphisms in peroxisome proliferator-activated receptor delta associated with obesity. Shin, H.D., Park, B.L., Kim, L.H., Jung, H.S., Cho, Y.M., Moon, M.K., Park, Y.J., Lee, H.K., Park, K.S. Diabetes (2004) [Pubmed]
  5. PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease. Holzapfel, J., Heun, R., L??tjohann, D., Jessen, F., Maier, W., K??lsch, H. Neurosci. Lett. (2006) [Pubmed]
  6. Mothers of children with autism or communication disorders: successful adaptation and the double ABCX model. Bristol, M.M. Journal of autism and developmental disorders. (1987) [Pubmed]
  7. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. He, T.C., Chan, T.A., Vogelstein, B., Kinzler, K.W. Cell (1999) [Pubmed]
  8. PPARs and the complex journey to obesity. Evans, R.M., Barish, G.D., Wang, Y.X. Nat. Med. (2004) [Pubmed]
  9. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Gupta, R.A., Wang, D., Katkuri, S., Wang, H., Dey, S.K., DuBois, R.N. Nat. Med. (2004) [Pubmed]
  10. Effect of topical PPARbeta/delta and PPARgamma agonists on plaque psoriasis. A pilot study. Kuenzli, S., Saurat, J.H. Dermatology (Basel) (2003) [Pubmed]
  11. Modulation of the expression of peroxisome proliferators-activated receptors in human fibroblasts. Diamond, M.P., Saed, G. Fertil. Steril. (2007) [Pubmed]
  12. Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Gupta, R.A., Tan, J., Krause, W.F., Geraci, M.W., Willson, T.M., Dey, S.K., DuBois, R.N. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  13. Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. Langelier, B., Furet, J.P., Perruchot, M.H., Alessandri, J.M. J. Neurosci. Res. (2003) [Pubmed]
  14. Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial. Andrulionyte, L., Peltola, P., Chiasson, J.L., Laakso, M. Diabetes (2006) [Pubmed]
  15. Developmental regulation of prostacyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation period. Cammas, L., Reinaud, P., Bordas, N., Dubois, O., Germain, G., Charpigny, G. Reproduction (2006) [Pubmed]
  16. The human peroxisome proliferator-activated receptor (PPAR) subtype NUC1 represses the activation of hPPAR alpha and thyroid hormone receptors. Jow, L., Mukherjee, R. J. Biol. Chem. (1995) [Pubmed]
  17. The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages. Vosper, H., Patel, L., Graham, T.L., Khoudoli, G.A., Hill, A., Macphee, C.H., Pinto, I., Smith, S.A., Suckling, K.E., Wolf, C.R., Palmer, C.N. J. Biol. Chem. (2001) [Pubmed]
  18. Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor alpha. Combs, C.K., Bates, P., Karlo, J.C., Landreth, G.E. Neurochem. Int. (2001) [Pubmed]
  19. Regulatory role of peroxisome proliferator-activated receptor delta (PPAR delta) in muscle metabolism. A new target for metabolic syndrome treatment? Grimaldi, P.A. Biochimie (2005) [Pubmed]
  20. Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. Skogsberg, J., McMahon, A.D., Karpe, F., Hamsten, A., Packard, C.J., Ehrenborg, E. J. Intern. Med. (2003) [Pubmed]
  21. Characterization of the human peroxisome proliferator activated receptor delta gene and its expression. Skogsberg, J., Kannisto, K., Roshani, L., Gagne, E., Hamsten, A., Larsson, C., Ehrenborg, E. Int. J. Mol. Med. (2000) [Pubmed]
  22. Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives. Lampen, A., Carlberg, C., Nau, H. Eur. J. Pharmacol. (2001) [Pubmed]
  23. Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer. Babbar, N., Ignatenko, N.A., Casero, R.A., Gerner, E.W. J. Biol. Chem. (2003) [Pubmed]
  24. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. Zuo, X., Wu, Y., Morris, J.S., Stimmel, J.B., Leesnitzer, L.M., Fischer, S.M., Lippman, S.M., Shureiqi, I. Oncogene (2006) [Pubmed]
  25. Prostacyclin-dependent apoptosis mediated by PPAR delta. Hatae, T., Wada, M., Yokoyama, C., Shimonishi, M., Tanabe, T. J. Biol. Chem. (2001) [Pubmed]
  26. Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein beta. Han, S., Ritzenthaler, J.D., Wingerd, B., Roman, J. J. Biol. Chem. (2005) [Pubmed]
  27. Waterborne gemfibrozil challenges the hepatic antioxidant defense system and down-regulates peroxisome proliferator-activated receptor beta (PPARbeta) mRNA levels in male goldfish (Carassius auratus). Mimeault, C., Trudeau, V.L., Moon, T.W. Toxicology (2006) [Pubmed]
  28. Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells. Fauconnet, S., Lascombe, I., Chabannes, E., Adessi, G.L., Desvergne, B., Wahli, W., Bittard, H. J. Biol. Chem. (2002) [Pubmed]
  29. Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners. Fehlberg, S., Trautwein, S., Göke, A., Göke, R. Biochem. J. (2002) [Pubmed]
  30. Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells. Xu, L., Han, C., Lim, K., Wu, T. Cancer Res. (2006) [Pubmed]
  31. Functional relationship between MyoD and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription. Solanes, G., Pedraza, N., Iglesias, R., Giralt, M., Villarroya, F. Mol. Endocrinol. (2003) [Pubmed]
  32. The increase in plasminogen activator inhibitor type-1 expression by stimulation of activators for peroxisome proliferator-activated receptors in human endothelial cells. Ye, P., Hu, X., Zhao, Y. Chin. Med. Sci. J. (2002) [Pubmed]
  33. Single Nucleotide Polymorphisms in the Peroxisome Proliferator-Activated Receptor {delta} Gene Are Associated With Skeletal Muscle Glucose Uptake. Vänttinen, M., Nuutila, P., Kuulasmaa, T., Pihlajamäki, J., Hällsten, K., Virtanen, K.A., Lautamäki, R., Peltoniemi, P., Takala, T., Viljanen, A.P., Knuuti, J., Laakso, M. Diabetes (2005) [Pubmed]
  34. BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells. Kharroubi, I., Lee, C.H., Hekerman, P., Darville, M.I., Evans, R.M., Eizirik, D.L., Cnop, M. Diabetologia (2006) [Pubmed]
  35. Three peroxisome proliferator-activated receptor isotypes from each of two species of marine fish. Leaver, M.J., Boukouvala, E., Antonopoulou, E., Diez, A., Favre-Krey, L., Ezaz, M.T., Bautista, J.M., Tocher, D.R., Krey, G. Endocrinology (2005) [Pubmed]
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