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Gene Review

Pparg  -  peroxisome proliferator-activated receptor...

Rattus norvegicus

Synonyms: Nr1c3, Nuclear receptor subfamily 1 group C member 3, PPAR-gamma, Peroxisome proliferator-activated receptor gamma
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Analytical, diagnostic and therapeutic context of Pparg


  1. Pioglitazone, a peroxisome proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance. Hasegawa, H., Takano, H., Zou, Y., Qin, Y., Hizukuri, K., Odaka, K., Toyozaki, T., Komuro, I. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  2. Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Collino, M., Aragno, M., Mastrocola, R., Gallicchio, M., Rosa, A.C., Dianzani, C., Danni, O., Thiemermann, C., Fantozzi, R. Eur. J. Pharmacol. (2006) [Pubmed]
  3. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation. Cuzzocrea, S., Pisano, B., Dugo, L., Ianaro, A., Maffia, P., Patel, N.S., Di Paola, R., Ialenti, A., Genovese, T., Chatterjee, P.K., Di Rosa, M., Caputi, A.P., Thiemermann, C. Eur. J. Pharmacol. (2004) [Pubmed]
  4. Decreased expression of peroxisome proliferator-activated receptor gamma in endotoxin-induced acute lung injury. Liu, D., Zeng, B.X., Shang, Y. Physiological research / Academia Scientiarum Bohemoslovaca. (2006) [Pubmed]
  5. Induction of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma during nitric oxide-induced apoptotic PC12 cell death. Lim, S.Y., Jang, J.H., Surh, Y.J. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  6. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Hu, E., Kim, J.B., Sarraf, P., Spiegelman, B.M. Science (1996) [Pubmed]
  7. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Kelly, D., Campbell, J.I., King, T.P., Grant, G., Jansson, E.A., Coutts, A.G., Pettersson, S., Conway, S. Nat. Immunol. (2004) [Pubmed]
  8. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., Yazaki, Y., Kadowaki, T. J. Clin. Invest. (1998) [Pubmed]
  9. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. De Vos, P., Lefebvre, A.M., Miller, S.G., Guerre-Millo, M., Wong, K., Saladin, R., Hamann, L.G., Staels, B., Briggs, M.R., Auwerx, J. J. Clin. Invest. (1996) [Pubmed]
  10. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Way, J.M., Harrington, W.W., Brown, K.K., Gottschalk, W.K., Sundseth, S.S., Mansfield, T.A., Ramachandran, R.K., Willson, T.M., Kliewer, S.A. Endocrinology (2001) [Pubmed]
  11. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Siddiqui, A.M., Cui, X., Wu, R., Dong, W., Zhou, M., Hu, M., Simms, H.H., Wang, P. Crit. Care Med. (2006) [Pubmed]
  12. PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Laplante, M., Sell, H., MacNaul, K.L., Richard, D., Berger, J.P., Deshaies, Y. Diabetes (2003) [Pubmed]
  13. Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma. Kim, S.Y., Kim, H.I., Park, S.K., Im, S.S., Li, T., Cheon, H.G., Ahn, Y.H. Diabetes (2004) [Pubmed]
  14. Placental expression of peroxisome proliferator-activated receptors in rat pregnancy and the effect of increased glucocorticoid exposure. Hewitt, D.P., Mark, P.J., Waddell, B.J. Biol. Reprod. (2006) [Pubmed]
  15. Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene. Sugawara, A., Takeuchi, K., Uruno, A., Kudo, M., Sato, K., Ito, S. Hypertens. Res. (2003) [Pubmed]
  16. Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells. Uchimura, K., Nakamuta, M., Enjoji, M., Irie, T., Sugimoto, R., Muta, T., Iwamoto, H., Nawata, H. Hepatology (2001) [Pubmed]
  17. Fasting increases gene expressions of uncoupling proteins and peroxisome proliferator-activated receptor-gamma in brown adipose tissue of ventromedial hypothalamus-lesioned rats. Kageyama, H., Osaka, T., Kageyama, A., Kawada, T., Hirano, T., Oka, J., Miura, M., Namba, Y., Ricquier, D., Shioda, S., Inoue, S. Life Sci. (2003) [Pubmed]
  18. Peroxisome proliferator-activated receptor gamma regulates angiotensin II-stimulated phosphatidylinositol 3-kinase and mitogen-activated protein kinase in blood vessels in vivo. Benkirane, K., Viel, E.C., Amiri, F., Schiffrin, E.L. Hypertension (2006) [Pubmed]
  19. Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia. Yang, M.S., Ji, K.A., Jeon, S.B., Jin, B.K., Kim, S.U., Jou, I., Joe, E. J. Immunol. (2006) [Pubmed]
  20. A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage. Shimizu, T., Szalay, L., Hsieh, Y.C., Suzuki, T., Choudhry, M.A., Bland, K.I., Chaudry, I.H. Ann. Surg. (2006) [Pubmed]
  21. 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. Sawano, H., Haneda, M., Sugimoto, T., Inoki, K., Koya, D., Kikkawa, R. Kidney Int. (2002) [Pubmed]
  22. Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migration. Goetze, S., Kintscher, U., Kim, S., Meehan, W.P., Kaneshiro, K., Collins, A.R., Fleck, E., Hsueh, W.A., Law, R.E. J. Cardiovasc. Pharmacol. (2001) [Pubmed]
  23. Inhibition of rat mammary gland carcinogenesis by simultaneous targeting of cyclooxygenase-2 and peroxisome proliferator-activated receptor gamma. Badawi, A.F., Eldeen, M.B., Liu, Y., Ross, E.A., Badr, M.Z. Cancer Res. (2004) [Pubmed]
  24. PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein. Ito, E., Ozawa, S., Takahashi, K., Tanaka, T., Katsuta, H., Yamaguchi, S., Maruyama, M., Takizawa, M., Katahira, H., Yoshimoto, K., Nagamatsu, S., Ishida, H. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  25. Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion. Sato, N., Kozar, R.A., Zou, L., Weatherall, J.M., Attuwaybi, B., Moore-Olufemi, S.D., Weisbrodt, N.W., Moore, F.A. Shock (2005) [Pubmed]
  26. Regulation of uncoupling protein-2 mRNA in L6 myotubules: I: Thiazolidinediones stimulate uncoupling protein-2 gene expression by a mechanism requiring ongoing protein synthesis and an active mitogen-activated protein kinase. López-Solache, I., Marie, V., Vignault, E., Camirand, A., Silva, J.E. Endocrine (2002) [Pubmed]
  27. Cardioprotective effects of rosiglitazone are associated with selective overexpression of type 2 angiotensin receptors and inhibition of p42/44 MAPK. Molavi, B., Chen, J., Mehta, J.L. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  28. Differential effects of phthalates on the testis and the liver. Bhattacharya, N., Dufour, J.M., Vo, M.N., Okita, J., Okita, R., Kim, K.H. Biol. Reprod. (2005) [Pubmed]
  29. NF-kappa B-binding activity in an animal diet-induced overweightness model and the impact of subsequent energy restriction. Lamas, O., Moreno-Aliaga, M.J., Martinez, J.A., Marti, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  30. Peroxisome Proliferator-Activated Receptor-gamma Agonists Diminish Peritoneal Functional and Morphological Changes Induced by Bioincompatible Peritoneal Dialysis Solution. Yao, Q., Pawlaczyk, K., Ayala, E.R., Kuzlan, M., Styszynski, A., Breborowicz, A., Heimburger, O., Qian, J., Stenvinkel, P., Axelsson, J., Lindholm, B. Blood Purif. (2006) [Pubmed]
  31. Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro. Routh, R.E., Johnson, J.H., McCarthy, K.J. Kidney Int. (2002) [Pubmed]
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