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Gene Review

ERC2  -  ELKS/RAB6-interacting/CAST family member 2

Homo sapiens

Synonyms: CAST, CAST1, ELKSL, ERC protein 2, KIAA0378, ...
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Disease relevance of ERC2

  • Classification of antiarrhythmic actions is reviewed in the context of the results of the Cardiac Arrhythmia Suppression Trials, CAST 1 and 2 [1].
  • The dog sera were from animals diagnosed with blastomycosis from various endemic regions in North America. T-58 and ERC-2 lysate antigens exhibited a high reactivity with the serum from dogs infected with blastomycosis; however, 48089 lysate showed low reactivity with the same sera [2].

High impact information on ERC2

  • In order of increasing laser resistance the following results were obtained: injection molded PMMA (1.9/GW/cm2) Silicone (2.63 GW/cm2) Lathe-cut PMMA (4.47 GW/cm2), Lathe-cut PMMA with UV absorber (8.32 GW/cm2), Cast-molded PMMA (12.30 GW/cm2) [3].
  • Psychosocial predictors of mortality in the Cardiac Arrhythmia Suppression Trial-1 (CAST-1) [4].
  • There was no significant change in ouabain-resistant 22Na ERC 2 h after oral glucose [5].
  • Overall, the strength ranking (temperature range average/MPa) was: Cristobalite (10.1)>Beauty Cast (7.8)>Novocast (5.1)>Deguvest California (3.4) [6].
  • CONCLUSION: Cast dowel-space preparation had a negative influence on the sealing ability of the remnant root-canal filling material [7].

Biological context of ERC2

  • Soft Cast group had better range of motion and could walk better at 2 weeks, but these differences diminished at 6 weeks [8].

Anatomical context of ERC2

  • In this prospective, randomized study, short-term immobilization with semi-rigid (Soft Cast) and rigid (Scotchcast Plus) synthetic cast materials were compared for the functional treatment of acute grade 3 lateral ligament injuries of the ankle [8].

Analytical, diagnostic and therapeutic context of ERC2

  • When combined with the reduced cost of application, Soft Cast is the material of choice for the initial short-term immobilization for the functional treatment of acute ankle ligament injuries [8].


  1. Classifying antiarrhythmic actions: by facts or speculation. Vaughan Williams, E.M. Journal of clinical pharmacology. (1992) [Pubmed]
  2. Serological differences in three Blastomyces dermatitidis strains. Axtell, R.C., Scalarone, G.M. Mycoses (2002) [Pubmed]
  3. A comparison of Nd:YAG laser damage thresholds for PMMA and silicone intraocular lenses. Bath, P.E., Romberger, A.B., Brown, P. Invest. Ophthalmol. Vis. Sci. (1986) [Pubmed]
  4. Psychosocial predictors of mortality in the Cardiac Arrhythmia Suppression Trial-1 (CAST-1). Gorkin, L., Schron, E.B., Brooks, M.M., Wiklund, I., Kellen, J., Verter, J., Schoenberger, J.A., Pawitan, Y., Morris, M., Shumaker, S. Am. J. Cardiol. (1993) [Pubmed]
  5. The effect of oral glucose on the leucocyte sodium pump in normal and obese subjects. Ng, L.L., Hockaday, T.D. Clin. Endocrinol. (Oxf) (1987) [Pubmed]
  6. Effect of burnout temperature on strength of gypsum-bonded investments. Luk, W.K., Darvell, B.W. Dental materials : official publication of the Academy of Dental Materials. (2003) [Pubmed]
  7. An in vitro study of coronal leakage after intraradicular preparation of cast-dowel space. Pappen, A.F., Bravo, M., Gonzalez-Lopez, S., Gonzalez-Rodriguez, M.P. The Journal of prosthetic dentistry. (2005) [Pubmed]
  8. Comparison of the results of short-term rigid and semi-rigid cast immobilization for the treatment of grade 3 inversion injuries of the ankle. Avci, S., Sayli, U. Injury. (1998) [Pubmed]
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