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Chemical Compound Review

Silicone     silicon

Synonyms: Silicium, Silizium, NanoFET, SILICON, silicio, ...
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Disease relevance of silicon


Psychiatry related information on silicon


High impact information on silicon

  • 2) Silicon is necessary for the association between cells and one or more macromolecules such as osteonectin, which affects cartilage composition and ultimately cartilage calcification [7].
  • The LONI Pipeline Processing Environment's parallel processing efficiency using an integrated client/server dataflow model was 80.9% when running the atlas generation pipeline from a PC client (Acer TravelMate 340T) on 48 dedicated server processors (Silicon Graphics Inc. Origin 3000) [8].
  • Nanoscale Patterning of Two Metals on Silicon Surfaces Using an ABC Triblock Copolymer Template [9].
  • Several recently constructed detailed kinetic models on metabolism (glycolysis), signal transduction (EGF receptor), and the eukaryotic cell cycle (Saccharomyces cerevisiae) have been used to exemplify the Silicon Cell project [10].
  • These results suggest that an active transport system for Si uptake is disrupted in GR1 [11].

Chemical compound and disease context of silicon


Biological context of silicon


Anatomical context of silicon

  • Adult rats were submitted to an 8-mm resection of the sciatic nerve repaired by autograft (AG, n = 9), silicone (SIL, n = 13) or poly-L-lactate-epsilon-caprolactone (PLC, n = 11) single guides, and fascicular tubulization of peroneal and tibial branches with a dual silicone tube (FSIL, n = 9) [21].
  • METHODS: Silicone particles were injected into the anterior chamber of rabbit eyes as tracers to monitor aqueous flow [22].
  • Low Mac-1 expression levels (<10%) accompanied by a low percentage of adhering neutrophils (<10%) were observed for polyethylene (PE), polyisoprene (PI), and silicone (SI) beads [23].
  • METHODS: Silicon elastic catheters were inserted into New Zealand White rabbit external jugular veins from 24 hours to 60 days [24].
  • METHODS: Silicone punctal plugs and collagen implants were exposed to S epidermidis (3 x 10(8) colony forming units/mL) for 0, 5, 30, and 60 minutes, rinsed in sterile saline, and processed for light, scanning (SEM), and transmission (TEM) electron microscopy [25].

Associations of silicon with other chemical compounds

  • Adults rats were submitted to non repaired sciatic nerve crush (CRH, n = 9), section repaired by either aligned epineurial suture (CS, n = 11) or silicone tube (SIL4, n = 13), and 8 mm resection repaired by tubulization (SIL8, n = 12) [26].
  • Using GeneSpring 5.0 (Silicon Genetics) software, transcripts were identified that were upregulated 2-fold or more by DHT in the caput (33 transcripts), the corpus (8 transcripts), and the cauda (9 transcripts) [27].
  • The biotubes were prepared by embedding six kinds of polymeric rods [poly(ethylene) (PE), poly(fluoroacetate) (PFA), poly(methyl methacrylate) (PMMA), segmented poly(urethane) (PU), poly(vinyl chloride) (PVC), and silicone (Si)] as a mold in six subcutaneous pouches in the dorsal skin of New Zealand White rabbits [28].
  • ODS and SI, demonstrating a non-linearity of these parameters with the wettability of materials [29].
  • A randomized comparative study of the Copper T 300, the standard Dalkon Shield and the Silicone Shell Loop D was conducted on 776 parous women [30].

Gene context of silicon

  • On a 100-MHz MIPS R4000 processor (Silicon Graphics Indigo), Sculpt achieves 11 updates per second on a 20-residue fragment and 2 updates per second on an 80-residue protein, using all atoms except non-H-bonding hydrogens, and without electrostatic interactions [31].
  • The segment match modeling method is fully automatic, yields a complete set of atomic co-ordinates without any human intervention and is efficient (14 s/residue on the Silicon Graphics 4D/25 Personal Iris workstation [32].
  • The analysis was carried out using the Atlas Image 2.01 (Clontech) and GeneSpring 4.2 (Silicon Genetics) softwares [33].
  • The Silicone Study. A small piece of the PVR puzzle is put into place [34].
  • Preadsorption of FN on the material surfaces increased subsequent cell spreading and cytoskeletal reorganization on hydrophobic surfaces except SI [35].

Analytical, diagnostic and therapeutic context of silicon


  1. Silicon carbide-coated stents: clinical experience in coronary lesions with increased thrombotic risk. Heublein, B., Ozbek, C., Pethig, K. Journal of endovascular surgery : the official journal of the International Society for Endovascular Surgery. (1998) [Pubmed]
  2. Anterior proliferative vitreoretinopathy in the silicone study. Silicone Study Report Number 10. Diddie, K.R., Azen, S.P., Freeman, H.M., Boone, D.C., Aaberg, T.M., Lewis, H., Radtke, N.D., Ryan, S.J. Ophthalmology (1996) [Pubmed]
  3. Silicone oil tamponade to seal macular holes without position restrictions. Goldbaum, M.H., McCuen, B.W., Hanneken, A.M., Burgess, S.K., Chen, H.H. Ophthalmology (1998) [Pubmed]
  4. The National Cancer Institute Silicone Implant/Multiple Myeloma Registry. Rabkin, C.S., Silverman, S., Tricot, G., Garland, L.L., Ballester, O., Potter, M. Curr. Top. Microbiol. Immunol. (1996) [Pubmed]
  5. Vitrectomy with silicone oil or long-acting gas in eyes with severe proliferative vitreoretinopathy: results of additional and long-term follow-up. Silicone Study report 11. Abrams, G.W., Azen, S.P., McCuen, B.W., Flynn, H.W., Lai, M.Y., Ryan, S.J. Arch. Ophthalmol. (1997) [Pubmed]
  6. Diffusion characteristics of microfabricated silicon nanopore membranes as immunoisolation membranes for use in cellular therapeutics. Smith, C., Kirk, R., West, T., Bratzel, M., Cohen, M., Martin, F., Boiarski, A., Rampersaud, A.A. Diabetes Technol. Ther. (2005) [Pubmed]
  7. Nutritional requirements for boron, silicon, vanadium, nickel, and arsenic: current knowledge and speculation. Nielsen, F.H. FASEB J. (1991) [Pubmed]
  8. The LONI Pipeline Processing Environment. Rex, D.E., Ma, J.Q., Toga, A.W. Neuroimage (2003) [Pubmed]
  9. Nanoscale Patterning of Two Metals on Silicon Surfaces Using an ABC Triblock Copolymer Template. Aizawa, M., Buriak, J.M. J. Am. Chem. Soc. (2006) [Pubmed]
  10. The Silicon Cell initiative: working towards a detailed kinetic description at the cellular level. Snoep, J.L. Curr. Opin. Biotechnol. (2005) [Pubmed]
  11. A rice mutant defective in Si uptake. Ma, J.F., Tamai, K., Ichii, M., Wu, G.F. Plant Physiol. (2002) [Pubmed]
  12. Regional myocardial perfusion of cardioplegic solutions. Eugene, J., Lyons, K.P., Ott, R.A., Gelezunas, V.L., Chang, C.W., Kowall, M.G., Haiduc, N.J. Ann. Thorac. Surg. (1987) [Pubmed]
  13. Bounds in the sensitivity of BioMEMS devices for cell detection. Bhalerao, K.D., Mwenifumbo, S.C., Soboyejo, A.B., Soboyejo, W.O. Biomedical microdevices. (2004) [Pubmed]
  14. 5-lipoxygenase inhibitor (AA-861) attenuates neutrophil-mediated oxidative stress on the venular endothelium in endotoxemia. Suematsu, M., Miura, S., Suzuki, M., Nagata, H., Morishita, T., Oshio, C., Tsuchiya, M. Journal of clinical & laboratory immunology. (1988) [Pubmed]
  15. Endocranial vascular patterns in a familial rabbit model of coronal suture synostosis. Burrows, A.M., O'Loughlin, V.D., Mooney, M.P., Smith, T.D., Losken, H.W., Siegel, M.I. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. (2001) [Pubmed]
  16. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. Colangelo, V., Schurr, J., Ball, M.J., Pelaez, R.P., Bazan, N.G., Lukiw, W.J. J. Neurosci. Res. (2002) [Pubmed]
  17. Postoperative intraocular pressure abnormalities in the Silicone Study. Silicone Study Report 4. Barr, C.C., Lai, M.Y., Lean, J.S., Linton, K.L., Trese, M., Abrams, G., Ryan, S.J., Azen, S.P. Ophthalmology (1993) [Pubmed]
  18. The prognostic utility of the Silicone Study Classification System. Silicone Study Report 9. Silicone Study Group. Lean, J., Azen, S.P., Lopez, P.F., Qian, D., Lai, M.Y., McCuen, B. Arch. Ophthalmol. (1996) [Pubmed]
  19. The incidence of corneal abnormalities in the Silicone Study. Silicone Study Report 7. Abrams, G.W., Azen, S.P., Barr, C.C., Lai, M.Y., Hutton, W.L., Trese, M.T., Irvine, A., Ryan, S.J. Arch. Ophthalmol. (1995) [Pubmed]
  20. Anti-insulin antibody structure and conformation. I. Molecular modeling and mechanics of an insulin antibody. Nell, L.J., McCammon, J.A., Subramaniam, S. Biopolymers (1992) [Pubmed]
  21. Functional impact of axonal misdirection after peripheral nerve injuries followed by graft or tube repair. Valero-Cabré, A., Navarro, X. J. Neurotrauma (2002) [Pubmed]
  22. Demonstration of aqueous streaming through a laser iridotomy window against the corneal endothelium. Yamamoto, Y., Uno, T., Shisida, K., Xue, L., Shiraishi, A., Zheng, X., Ohashi, Y. Arch. Ophthalmol. (2006) [Pubmed]
  23. Simultaneous measurement of biopolymer-mediated Mac-1 up-regulation and adherence of neutrophils: a novel flow cytometric approach for predicting initial inflammatory interaction with foreign materials. Peltroche-Llacsahuanga, H., Schmidt, S., Schnitzler, N., Lütticken, R., Haase, G. J. Immunol. Methods (2001) [Pubmed]
  24. Role of platelet activation in catheter-induced vascular wall injury. Zolpi, E., Filipetto, C., Bertipaglia, B., Taiani, J., Gasparotto, L., Chiavegato, A., Gamba, P., Sartore, S. J. Endovasc. Ther. (2004) [Pubmed]
  25. In vitro adherence of Staphylococcus epidermidis to silicone punctual plugs and collagen implants. John, T., Kopstein, A.B., John, O.C., Lai, C.I., Carey, R.B. Journal of cataract and refractive surgery. (2001) [Pubmed]
  26. Changes in crossed spinal reflexes after peripheral nerve injury and repair. Valero-Cabré, A., Navarro, X. J. Neurophysiol. (2002) [Pubmed]
  27. Androgen-regulated genes in the murine epididymis. Chauvin, T.R., Griswold, M.D. Biol. Reprod. (2004) [Pubmed]
  28. In vivo tissue-engineered small-caliber arterial graft prosthesis consisting of autologous tissue (biotube). Nakayama, Y., Ishibashi-Ueda, H., Takamizawa, K. Cell transplantation. (2004) [Pubmed]
  29. Studies on cell-biomaterial interaction: role of tyrosine phosphorylation during fibroblast spreading on surfaces varying in wettability. Groth, T., Altankov, G. Biomaterials (1996) [Pubmed]
  30. Randomized comparative study of the copper T 300, Dalkon shield, and Shell Loop in parous women. Cooper, D.L., Israel, R., Mishell, D.R. Obstetrics and gynecology. (1975) [Pubmed]
  31. Sculpting proteins interactively: continual energy minimization embedded in a graphical modeling system. Surles, M.C., Richardson, J.S., Richardson, D.C., Brooks, F.P. Protein Sci. (1994) [Pubmed]
  32. Accurate modeling of protein conformation by automatic segment matching. Levitt, M. J. Mol. Biol. (1992) [Pubmed]
  33. Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy. Blasco, F., Peñuelas, S., Cascalló, M., Hernández, J.L., Alemany, C., Masa, M., Calbó, J., Soler, M., Nicolás, M., Pérez-Torras, S., Gómez, A., Tarrasón, G., Noé, V., Mazo, A., Ciudad, C.J., Piulats, J. Oncology (2004) [Pubmed]
  34. The Silicone Study. A small piece of the PVR puzzle is put into place. Campochiaro, P.A. Arch. Ophthalmol. (1997) [Pubmed]
  35. Studies on the biocompatibility of materials: fibroblast reorganization of substratum-bound fibronectin on surfaces varying in wettability. Altankov, G., Grinnell, F., Groth, T. J. Biomed. Mater. Res. (1996) [Pubmed]
  36. Tissue adhesion to bioactive glass-coated silicone tubing in a rat model of peritoneal dialysis catheters and catheter tunnels. Ross, E.A., Batich, C.D., Clapp, W.L., Sallustio, J.E., Lee, N.C. Kidney Int. (2003) [Pubmed]
  37. The validity and reliability of photographic documentation of proliferative vitreoretinopathy. Azen, S.P., Irvine, A.R., Davis, M.D., Stern, W., Lonn, L., Hilton, G., Schwartz, A., Boone, D., Quillen-Thomas, B., Lyons, M. Ophthalmology (1989) [Pubmed]
  38. Early and late complications of silicone patch saphenoplasty at the saphenofemoral junction. De Maeseneer, M.G., Vandenbroeck, C.P., Lauwers, P.R., Hendriks, J.M., De Hert, S.G., Van Schil, P.E. J. Vasc. Surg. (2006) [Pubmed]
  39. The epidemiology of scleroderma among women: assessment of risk from exposure to silicone and silica. Burns, C.J., Laing, T.J., Gillespie, B.W., Heeringa, S.G., Alcser, K.H., Mayes, M.D., Wasko, M.C., Cooper, B.C., Garabrant, D.H., Schottenfeld, D. J. Rheumatol. (1996) [Pubmed]
  40. Single-tube two-round polymerase chain reaction using the LightCycler instrument. Berg, J., Nagl, V., Mühlbauer, G., Stekel, H. J. Clin. Virol. (2001) [Pubmed]
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