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Chemical Compound Review

AC1MHUAZ     methyl 2-methylpropanoate

Synonyms: 154182-EP2284169A1, 154182-EP2287161A1, 154182-EP2287162A1, Methyl methacrylate resin, 1-methyl-1-methoxycarbonylethyl, ...
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Disease relevance of Polymethyl methacrylate


Psychiatry related information on Polymethyl methacrylate

  • Although several of the analogs produced up to 50-60% MDMA-appropriate responding, none [with the exception of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA)] resulted in stimulus generalization [6].

High impact information on Polymethyl methacrylate

  • One group underwent dialysis with the widely used cuprophane dialysis membrane, which activates the complement system and leukocytes, and the other group underwent dialysis with a synthetic polymethyl methacrylate membrane, which has a more limited effect on complement and leukocytes [1].
  • METHODS: 180 patients with acute renal failure were randomly assigned bioincompatible Cuprophan (n=90) or polymethyl-methacrylate (n=90) membranes [2].
  • Vis-NIR spectra of all structures were analyzed to reveal the internal architecture with each PS sphere correlating to 21-23 PMMA particles (a LI21-23 stoichiometry), which corresponded well with computer models [7].
  • In situ hydrogenation of terminal halogen in poly(methyl methacrylate) by ruthenium-catalyzed living radical polymerization: direct transformation of "polymerization catalyst" into "hydrogenation catalyst" [8].
  • Intriguing surface morphologies composed of relatively ordered nanoscale domains were found from mixed brushes with PS M(n) slightly smaller than or similar to that of PMMA after treatment with acetic acid, a selective solvent for PMMA [9].

Chemical compound and disease context of Polymethyl methacrylate


Biological context of Polymethyl methacrylate

  • The Janus micelles were obtained via cross-linking the middle block of a microphase-separated PS-block-PB-block-PMMA triblock copolymer in the bulk state, followed by alkaline hydrolysis of the poly(methyl methacrylate) (PMMA) ester groups [15].
  • Real-time LDR-spFRET detection of point mutations in the K-ras gene was accomplished in PMMA microfluidic devices using sheath flows [16].
  • Over the force range investigated, each modified surface was found to induce a significantly different degree of cell adhesion than that caused by PMMA [17].
  • We believe that the PMMA with high molecular weight enwraps the rare earth complexes and keeps the donors and acceptors close, which results in the effective intermolecular energy transfer and, consequently, the high sensitization efficiency [18].
  • Furthermore, SEM observations highlighted two different patterns of bacterial adhesion (isolated bacteria and clusters of bacteria), assuming that hydrophobic IOLs (silicone and PMMA) probably facilitate bacterial colonization and biofilm production [19].

Anatomical context of Polymethyl methacrylate

  • Depletion of ionized calcium markedly reduced PMMA-mediated neutrophil degranulation in the extracorporeal circuit [3].
  • Placement of a polymethyl methacrylate (PMMA) contact lens on the cornea caused swelling rates of 15-28 microns/hr compared to 0-6 microns/hr in paired control corneas [20].
  • The detection of human immunoglobulin M (IgM) was performed using capacitively coupled contactless conductivity detection (CCD) in electrophoresis carried out in conventional capillaries as well as on glass and poly(meth-yl methacrylate) (PMMA) microdevices [21].
  • PURPOSE: To determine changes in topographical thickness of the epithelium and total cornea after hydrogel (2-hydroxyethyl methacrylate; HEMA or soft lens) and PMMA rigid contact lens wear with eyes closed, as measured by optical coherence tomography (OCT) [22].
  • Actin filaments were seen to move precisely only on the PMMA tracks, and their traces drew the exact shapes of the tracks [23].

Associations of Polymethyl methacrylate with other chemical compounds


Gene context of Polymethyl methacrylate


Analytical, diagnostic and therapeutic context of Polymethyl methacrylate


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  10. The physiologic effects of extended wear soft contact lenses. Binder, P.S. Ophthalmology (1980) [Pubmed]
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  14. Posterior capsule opacification in eyes with a silicone or poly(methyl methacrylate) intraocular lens. Kim, M.J., Lee, H.Y., Joo, C.K. Journal of cataract and refractive surgery. (1999) [Pubmed]
  15. Amphiphilic Janus micelles with polystyrene and poly(methacrylic acid) hemispheres. Erhardt, R., Zhang, M., Böker, A., Zettl, H., Abetz, C., Frederik, P., Krausch, G., Abetz, V., Müller, A.H. J. Am. Chem. Soc. (2003) [Pubmed]
  16. Approaching real-time molecular diagnostics: single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes. Wabuyele, M.B., Farquar, H., Stryjewski, W., Hammer, R.P., Soper, S.A., Cheng, Y.W., Barany, F. J. Am. Chem. Soc. (2003) [Pubmed]
  17. Relating the surface properties of intraocular lens materials to endothelial cell adhesion damage. Mateo, N.B., Ratner, B.D. Invest. Ophthalmol. Vis. Sci. (1989) [Pubmed]
  18. Combinatorial study of cofluorescence of rare earth organic complexes doped in the poly(methyl methacrylate) matrix. Ding, J.J., Jiu, H.F., Bao, J., Lu, J.C., Gui, W.R., Zhang, Q.J., Gao, C. Journal of combinatorial chemistry. (2005) [Pubmed]
  19. Bacterial adherence of Staphylococcus epidermidis to intraocular lenses: a bioluminescence and scanning electron microscopy study. Kodjikian, L., Burillon, C., Roques, C., Pellon, G., Freney, J., Renaud, F.N. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  20. Contact lens-induced edema in vitro. Ion transport and metabolic considerations. Huff, J.W. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  21. Detection of human immunoglobulin in microchip and conventional capillary electrophoresis with contactless conductivity measurements. Abad-Villar, E.M., Tanyanyiwa, J., Fernández-Abedul, M.T., Costa-García, A., Hauser, P.C. Anal. Chem. (2004) [Pubmed]
  22. Topographical thickness of the epithelium and total cornea after hydrogel and PMMA contact lens wear with eye closure. Wang, J., Fonn, D., Simpson, T.L. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  23. Control of actin moving trajectory by patterned poly(methylmethacrylate) tracks. Suzuki, H., Yamada, A., Oiwa, K., Nakayama, H., Mashiko, S. Biophys. J. (1997) [Pubmed]
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  28. Map kinase c-JUN N-terminal kinase mediates PMMA induction of osteoclasts. Yamanaka, Y., Abu-Amer, Y., Faccio, R., Clohisy, J.C. J. Orthop. Res. (2006) [Pubmed]
  29. Inhibition of IKK activation, through sequestering NEMO, blocks PMMA-induced osteoclastogenesis and calvarial inflammatory osteolysis. Clohisy, J.C., Yamanaka, Y., Faccio, R., Abu-Amer, Y. J. Orthop. Res. (2006) [Pubmed]
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