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Gene Review:

HYALP1 - hyaluronoglucosaminidase pseudogene 1

Homo sapiens

Synonyms: HYAL6

Miller, K.A. et al., Csóka, A.B. et al.

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High impact information on HYALP1

3. One of these (HYALP1) is an expressed pseudogene with mutations in the genomic DNA and cDNA [1].
In this study we show that one of the murine hyases, Hyalp1, which is predominantly expressed in the testis in a 24-kd isoform has neutral enzymatic activity [2].
Antibody-inhibited Spam1 null sperm were more severely retarded (P = 4.2 x 10(-19)), suggesting an up-regulation of Hyalp1 in these mice [2].
On sperm, Hyalp1 is localized on the plasma membrane of the anterior head and was shown to have neutral hyase activity for an isoform of approximately 55-56 kd, contributing modestly to the overall neutral hyase activity [2].
Finally, developmental reverse transcription polymerase chain reaction (RT-PCR) shows that testicular transcripts of Hyalp1 are detected as early as 6 days postparturition, similar to transcripts for Spam1, suggesting that the gene might also play a role in the developing testes prior to spermiogenesis [2].

Anatomical context of HYALP1

A functionality test of the hyaluronic acid (HA) receptor domain identified in the N-terminus by in silico analysis revealed that sperm Hyalp1 is significantly (P = .006) involved in the progesterone-induced HA-enhanced acrosome reaction [2].

References

Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. Csóka, A.B., Scherer, S.W., Stern, R. Genomics (1999) [Pubmed]
Hyalp1 in murine sperm function: evidence for unique and overlapping functions with other reproductive hyaluronidases. Miller, K.A., Shao, M., Martin-Deleon, P.A. J. Androl. (2007) [Pubmed]

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