Disease relevance of ERAL1

• Retrovirus expression cassettes were used to generate the HSV-EBV-retrovirus hybrid vectors, HERE and HERA, which code for the ecotropic and the amphotropic envelopes, respectively [1].
• METHODS: HERA is an international multicentre randomised trial that compared 1 or 2 years of trastuzumab treatment with observation alone after standard neoadjuvant or adjuvant chemotherapy in women with HER2-positive node positive or high-risk node negative breast cancer [2].

High impact information on ERAL1

• Many recent neuroimaging studies of episodic memory have indicated an asymmetry in prefrontal involvement, with the left prefrontal cortex more involved than the right in encoding, the right more than the left in retrieval (hemispheric encoding and retrieval asymmetry, or HERA model) [3].
• A characteristic feature of small-x lepton-proton data from HERA is geometric scaling: the fact that in the region of small Bjorken variable x, x less, similar 0.01, all data can be described by a single variable Q(2)/Q(2)(s,p)(x), with all x dependence encoded in the so-called saturation momentum Q(s,p)(x) [4].
• The Hermes experiment has investigated the tensor spin structure of the deuteron using the 27.6 GeV/c positron beam of DESY HERA [5].
• The Hera database and its use in the characterization of endoplasmic reticulum proteins [6].
• ERAL1 may be an attractive candidate for a tumor suppressor gene since ERAL1 is located in a chromosomal region where loss of heterozygosity is often associated with various types of cancer [7].

Biological context of ERAL1

• ERAL1 maps to 17q11.2 in human and is located in the syntenic region of mouse chromosome 11 [7].

Anatomical context of ERAL1

• In the proximal phalangeal lateral, floating, and fifth metatarsal types, the lat eral accessory sixth digit was excised [8].

Associations of ERAL1 with chemical compounds

• Near the pillars, a temple for sacrifices dedicated to Hera and a statue of Apollo manteion in the Prytaneoion have been found [9].
• The use of intraoperative vasopressors was significantly higher in the CEGA group (P < 0.01) but the use of intravenous glyceryl trinitrate was significantly lower (P < 0.01) [10].
• CEGA can control pain due to CO2-induced peritoneal irritation, providing excellent intra- and postoperative analgesia [11].

Analytical, diagnostic and therapeutic context of ERAL1

• In contrast, the HERA prediction of asymmetry was fitted only by EEG gamma responses, but only in the posterior parietal areas [3].
• Analgesia was better in the CEGA group, with VAS values at 0, 1, 2, 4, 6, 12 and 24 h significantly (p < 0.05) lower than those observed in the GA group [12].
• CONCLUSIONS: The use of CEGA for laparoscopic cholecystectomy seems to be effective and safe and to offer some advantages as compared to TIVA alone [11].
• MATERIALS AND METHODS: 50 patients scheduled for radical cystectomy were randomized to two groups: group GA - general anesthesia, n = 25 and group CEGA - combined epidural and general anesthesia [12].
• Fifty patients undergoing elective abdominal aortic surgery were randomised to receive either combined epidural and general anaesthesia and postoperative epidural analgesia (CEGA) or general anaesthesia and postoperative intravenous morphine infusion (GA) [10].

References