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Gene Review

GAPDHS  -  glyceraldehyde-3-phosphate dehydrogenase,...

Homo sapiens

Synonyms: GAPD2, GAPDH-2, GAPDH2, GAPDS, Glyceraldehyde-3-phosphate dehydrogenase, testis-specific, ...
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High impact information on GAPDHS


Biological context of GAPDHS

  • Using affinity matrices and RNA interference, we identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a GAPDS target [4].

Analytical, diagnostic and therapeutic context of GAPDHS

  • The structure of the human GAPD2 gene was determined by polymerase chain reaction (PCR) to identify exon-intron junctions in a genomic clone and in total genomic DNA [2].


  1. Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Miki, K., Qu, W., Goulding, E.H., Willis, W.D., Bunch, D.O., Strader, L.F., Perreault, S.D., Eddy, E.M., O'Brien, D.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells. Welch, J.E., Brown, P.L., O'Brien, D.A., Magyar, P.L., Bunch, D.O., Mori, C., Eddy, E.M. J. Androl. (2000) [Pubmed]
  3. Regulation of glyceraldehyde-3-phosphate dehydrogenase: inheritance and biochemistry of a low-activity genetic variant in the platyfish, Xiphophorus maculatus. Morizot, D.C., Wright, D.A., Siciliano, M.J. J. Exp. Zool. (1982) [Pubmed]
  4. Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. Min, J., Kyung Kim, Y., Cipriani, P.G., Kang, M., Khersonsky, S.M., Walsh, D.P., Lee, J.Y., Niessen, S., Yates, J.R., Gunsalus, K., Piano, F., Chang, Y.T. Nat. Chem. Biol. (2007) [Pubmed]
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