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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LHX6  -  LIM homeobox 6

Homo sapiens

Synonyms: LHX6.1, LIM homeobox protein 6, LIM/homeobox protein Lhx6, LIM/homeobox protein Lhx6.1
 
 
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Disease relevance of LHX6

 

High impact information on LHX6

  • The most frequently hypermethylated fragment we found maps close to a cytosine guanine dinucleotide (CpG) island on chromosome 9q33.2, and hypermethylation of this CpG island was associated with transcriptional silencing of an alternative transcript of the LHX6 gene [1].
  • Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes [2].
  • The manipulability, minimal cost and susceptibility of chicks to CL/P will enable more detailed investigations into how perturbations of IRF6, LHX6 and LHX7 contribute to common orofacial clefts [3].
  • LHX7 and LHX6 expression was restricted to the ectomesenchyme immediately underlying the ectoderm of the maxillary and mandibular primordia as well as to the lateral globular projections of the medial nasal process, again underlying the pre-fusion primary palatal epithelia [3].
 

Biological context of LHX6

  • RESULTS: Here we report the isolation of chick orthologues of LHX7, LHX6 and IRF6 and the first characterisation of their profiles of expression during morphogenesis of the midface with emphasis on the period around formation of the primary palate [3].

References

  1. LHX6 is a sensitive methylation marker in head and neck carcinomas. Estécio, M.R., Youssef, E.M., Rahal, P., Fukuyama, E.E., Góis-Filho, J.F., Maniglia, J.V., Goloni-Bertollo, E.M., Issa, J.P., Tajara, E.H. Oncogene (2006) [Pubmed]
  2. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. Liodis, P., Denaxa, M., Grigoriou, M., Akufo-Addo, C., Yanagawa, Y., Pachnis, V. J. Neurosci. (2007) [Pubmed]
  3. Expression profiles of cIRF6, cLHX6 and cLHX7 in the facial primordia suggest specific roles during primary palatogenesis. Washbourne, B.J., Cox, T.C. BMC Dev. Biol. (2006) [Pubmed]
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