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Gene Review

Lhx6  -  LIM homeobox protein 6

Mus musculus

Synonyms: LIM/homeobox protein Lhx6, LIM/homeobox protein Lhx6.1, Lhx6.1
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High impact information on Lhx6

  • Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus [1].
  • In the ventral telencephalon, although calbindin- and Lhx6-expressing cortical neurons were generated at embryonic day 12.5, their tangential migration into the neocortex was dramatically and specifically reduced in the mutant marginal zone [2].
  • Consistently, Lhx6, another target of Fgf8 signaling, is also upregulated in the Hoxa2(-/-) second arch mesenchyme [3].
  • We also present evidence implicating the Lhx6 and Lhx7 LIM-homeobox genes in the development of distinct interneuron subtypes [4].
  • In the mouse, embryonic expression of Clim-2 is particularly pronounced in facial ectomesenchyme and limb bud mesenchyme in association with Lim genes, Lhx-6 and Lmx-1 respectively [5].

Biological context of Lhx6


Anatomical context of Lhx6

  • More specifically, expression of Lhx6 and Lhx7 was detected prior to initiation of tooth formation in the presumptive oral and odontogenic mesenchyme of the maxillary and mandibular processes [6].
  • Using explant cultures, we have shown that expression of Lhx6 and Lhx7 in mandibular mesenchyme was under the control of signals derived from the overlying epithelium; such signals were absent from the epithelium of the non-odontogenic second branchial arch [6].
  • The expression pattern of mr-gef during early telencephalic neurogenesis is strikingly similar to that of GABA and the LIM homeobox gene Lhx6, a transcription factor expressed by GABAergic interneurons generated in the ventral telencephalon, some of which migrate into the cortex during development [9].

Other interactions of Lhx6

  • We have identified two genes belonging to a novel subfamily of mammalian Lhx genes, designated Lhx6 and Lhx7 [6].

Analytical, diagnostic and therapeutic context of Lhx6


  1. Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus. Choi, G.B., Dong, H.W., Murphy, A.J., Valenzuela, D.M., Yancopoulos, G.D., Swanson, L.W., Anderson, D.J. Neuron (2005) [Pubmed]
  2. A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration. Ferguson, K.L., McClellan, K.A., Vanderluit, J.L., McIntosh, W.C., Schuurmans, C., Polleux, F., Slack, R.S. EMBO J. (2005) [Pubmed]
  3. Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1. Bobola, N., Carapuço, M., Ohnemus, S., Kanzler, B., Leibbrandt, A., Neubüser, A., Drouin, J., Mallo, M. Development (2003) [Pubmed]
  4. Origin and molecular specification of striatal interneurons. Marin, O., Anderson, S.A., Rubenstein, J.L. J. Neurosci. (2000) [Pubmed]
  5. Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Tucker, A.S., Al Khamis, A., Ferguson, C.A., Bach, I., Rosenfeld, M.G., Sharpe, P.T. Development (1999) [Pubmed]
  6. Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Grigoriou, M., Tucker, A.S., Sharpe, P.T., Pachnis, V. Development (1998) [Pubmed]
  7. Lhx6 regulates the migration of cortical interneurons from the ventral telencephalon but does not specify their GABA phenotype. Alifragis, P., Liapi, A., Parnavelas, J.G. J. Neurosci. (2004) [Pubmed]
  8. New cellular models for tracking the odontoblast phenotype. Priam, F., Ronco, V., Locker, M., Bourd, K., Bonnefoix, M., Duchêne, T., Bitard, J., Wurtz, T., Kellermann, O., Goldberg, M., Poliard, A. Arch. Oral Biol. (2005) [Pubmed]
  9. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell, A., Alberta, J., Hornby, F., Stiles, C.D., Williams, B.P. Brain Res. Dev. Brain Res. (2003) [Pubmed]
  10. Comparison of the expression patterns of two LIM-homeodomain genes, Lhx6 and L3/Lhx8, in the developing palate. Zhang, Y., Mori, T., Takaki, H., Takeuch, M., Iseki, K., Hagino, S., Murakawa, M., Yokoya, S., Wanaka, A. Orthodontics & craniofacial research. (2002) [Pubmed]
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