Gene Review:
IRF6 - interferon regulatory factor 6
Homo sapiens
Synonyms:
IRF-6, Interferon regulatory factor 6, LPS, OFC6, PIT, ...
- Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. Kondo, S., Schutte, B.C., Richardson, R.J., Bjork, B.C., Knight, A.S., Watanabe, Y., Howard, E., de Lima, R.L., Daack-Hirsch, S., Sander, A., McDonald-McGinn, D.M., Zackai, E.H., Lammer, E.J., Aylsworth, A.S., Ardinger, H.H., Lidral, A.C., Pober, B.R., Moreno, L., Arcos-Burgos, M., Valencia, C., Houdayer, C., Bahuau, M., Moretti-Ferreira, D., Richieri-Costa, A., Dixon, M.J., Murray, J.C. Nat. Genet. (2002)
- Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. Bailey, C.M., Khalkhali-Ellis, Z., Kondo, S., Margaryan, N.V., Seftor, R.E., Wheaton, W.W., Amir, S., Pins, M.R., Schutte, B.C., Hendrix, M.J. J. Biol. Chem. (2005)
- Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population. Ghassibé, M., Bayet, B., Revencu, N., Verellen-Dumoulin, C., Gillerot, Y., Vanwijck, R., Vikkula, M. Eur. J. Hum. Genet. (2005)
- Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. Zucchero, T.M., Cooper, M.E., Maher, B.S., Daack-Hirsch, S., Nepomuceno, B., Ribeiro, L., Caprau, D., Christensen, K., Suzuki, Y., Machida, J., Natsume, N., Yoshiura, K., Vieira, A.R., Orioli, I.M., Castilla, E.E., Moreno, L., Arcos-Burgos, M., Lidral, A.C., Field, L.L., Liu, Y.E., Ray, A., Goldstein, T.H., Schultz, R.E., Shi, M., Johnson, M.K., Kondo, S., Schutte, B.C., Marazita, M.L., Murray, J.C. N. Engl. J. Med. (2004)
- Apolipoproteins modulate the inflammatory response to lipopolysaccharide. Berbée, J.F., Havekes, L.M., Rensen, P.C. J. Endotoxin Res. (2005)
- The effect of prospective payment on rehabilitative care. Dobrez, D.G., Lo Sasso, A.T., Heinemann, A.W. Archives of physical medicine and rehabilitation. (2004)
- Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women. Lebrun, C.E., van der Schouw, Y.T., de Jong, F.H., Pols, H.A., Grobbee, D.E., Lamberts, S.W. Maturitas. (2006)
- Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Ingraham, C.R., Kinoshita, A., Kondo, S., Yang, B., Sajan, S., Trout, K.J., Malik, M.I., Dunnwald, M., Goudy, S.L., Lovett, M., Murray, J.C., Schutte, B.C. Nat. Genet. (2006)
- Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Richardson, R.J., Dixon, J., Malhotra, S., Hardman, M.J., Knowles, L., Boot-Handford, R.P., Shore, P., Whitmarsh, A., Dixon, M.J. Nat. Genet. (2006)
- Prednisolone Dose-Dependently Influences Inflammation and Coagulation during Human Endotoxemia. de Kruif, M.D., Lemaire, L.C., Giebelen, I.A., van Zoelen, M.A., Pater, J.M., van den Pangaart, P.S., Groot, A.P., de Vos, A.F., Elliott, P.J., Meijers, J.C., Levi, M., van der Poll, T. J. Immunol. (2007)
- Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling. Essler, M., Staddon, J.M., Weber, P.C., Aepfelbacher, M. J. Immunol. (2000)
- Functional significance of factor H binding to Neisseria meningitidis. Schneider, M.C., Exley, R.M., Chan, H., Feavers, I., Kang, Y.H., Sim, R.B., Tang, C.M. J. Immunol. (2006)
- Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both. Ichinose, Y., Bakouche, O., Tsao, J.Y., Fidler, I.J. J. Immunol. (1988)
- Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia. van der Poll, T., Jansen, P.M., Montegut, W.J., Braxton, C.C., Calvano, S.E., Stackpole, S.A., Smith, S.R., Swanson, S.W., Hack, C.E., Lowry, S.F., Moldawer, L.L. J. Immunol. (1997)
- Novel mutations in the IRF6 gene for Van der Woude syndrome. Wang, X., Liu, J., Zhang, H., Xiao, M., Li, J., Yang, C., Lin, X., Wu, Z., Hu, L., Kong, X. Hum. Genet. (2003)
- Bacterial lipopolysaccharides: structure, metabolism and mechanisms of action. Freudenberg, M.A., Galanos, C. Int. Rev. Immunol. (1990)
- Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes. Schäkel, K., von Kietzell, M., Hänsel, A., Ebling, A., Schulze, L., Haase, M., Semmler, C., Sarfati, M., Barclay, A.N., Randolph, G.J., Meurer, M., Rieber, E.P. Immunity (2006)
- Opposite Regulation of IL-1beta and Secreted IL-1 Receptor Antagonist Production by Phosphatidylinositide-3 Kinases in Human Monocytes Activated by Lipopolysaccharides or Contact with T Cells. Molnarfi, N., Gruaz, L., Dayer, J.M., Burger, D. J. Immunol. (2007)
- Two missense mutations in the IRF6 gene in two Japanese families with Van der Woude syndrome. Matsuzawa, N., Yoshiura, K., Machida, J., Nakamura, T., Niimi, T., Furukawa, H., Toyoda, T., Natsume, N., Shimozato, K., Niikawa, N. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2004)
- Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. Nakahira, K., Kim, H.P., Geng, X.H., Nakao, A., Wang, X., Murase, N., Drain, P.F., Wang, X., Sasidhar, M., Nabel, E.G., Takahashi, T., Lukacs, N.W., Ryter, S.W., Morita, K., Choi, A.M. J. Exp. Med. (2006)
- Bcl10 plays a critical role in NF-{kappa}B activation induced by G protein-coupled receptors. Wang, D., You, Y., Lin, P.C., Xue, L., Morris, S.W., Zeng, H., Wen, R., Lin, X. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Wang, M., Zukas, A.M., Hui, Y., Ricciotti, E., Pur??, E., Fitzgerald, G.A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- A biosynthetic pathway for anandamide. Liu, J., Wang, L., Harvey-White, J., Osei-Hyiaman, D., Razdan, R., Gong, Q., Chan, A.C., Zhou, Z., Huang, B.X., Kim, H.Y., Kunos, G. Proc. Natl. Acad. Sci. U.S.A. (2006)
- LPS-binding protein circulates in association with apoB-containing lipoproteins and enhances endotoxin-LDL/VLDL interaction. Vreugdenhil, A.C., Snoek, A.M., van 't Veer, C., Greve, J.W., Buurman, W.A. J. Clin. Invest. (2001)
- Identification of novel mutations of IRF6 gene in Chinese families with Van der Woude syndrome. Ye, X.Q., Jin, H.X., Shi, L.S., Fan, M.W., Song, G.T., Fan, H.L., Bian, Z. Int. J. Mol. Med. (2005)
- Variation in IRF6 contributes to nonsyndromic cleft lip and palate. Blanton, S.H., Cortez, A., Stal, S., Mulliken, J.B., Finnell, R.H., Hecht, J.T. Am. J. Med. Genet. A (2005)
- Expression profiles of cIRF6, cLHX6 and cLHX7 in the facial primordia suggest specific roles during primary palatogenesis. Washbourne, B.J., Cox, T.C. BMC Dev. Biol. (2006)
- Peripheral blood neutrophil activation patterns are associated with pulmonary inflammatory responses to lipopolysaccharide in humans. Abraham, E., Nick, J.A., Azam, T., Kim, S.H., Mira, J.P., Svetkauskaite, D., He, Q., Zamora, M., Murphy, J., Park, J.S., Overdier, K., Dinarello, C.A. J. Immunol. (2006)
- T cell-independent, TLR-induced IL-12p70 production in primary human monocytes. Bekeredjian-Ding, I., Roth, S.I., Gilles, S., Giese, T., Ablasser, A., Hornung, V., Endres, S., Hartmann, G. J. Immunol. (2006)
- Cyclooxygenase-2 gene transcription in a macrophage model of inflammation. Kang, Y.J., Wingerd, B.A., Arakawa, T., Smith, W.L. J. Immunol. (2006)
- Escherichia coli Braun lipoprotein induces a lipopolysaccharide-like endotoxic response from primary human endothelial cells. Neilsen, P.O., Zimmerman, G.A., McIntyre, T.M. J. Immunol. (2001)