Gene Review:
Irak4 - interleukin-1 receptor-associated kinase 4
Mus musculus
Synonyms:
8430405M07Rik, 9330209D03Rik, IRAK-4, Interleukin-1 receptor-associated kinase 4, NY-REN-64
- Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. Burns, K., Janssens, S., Brissoni, B., Olivos, N., Beyaert, R., Tschopp, J. J. Exp. Med. (2003)
- Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. Asehnoune, K., Strassheim, D., Mitra, S., Kim, J.Y., Abraham, E. J. Immunol. (2004)
- IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. Suzuki, N., Chen, N.J., Millar, D.G., Suzuki, S., Horacek, T., Hara, H., Bouchard, D., Nakanishi, K., Penninger, J.M., Ohashi, P.S., Yeh, W.C. J. Immunol. (2003)
- IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. Suzuki, N., Suzuki, S., Eriksson, U., Hara, H., Mirtosis, C., Chen, N.J., Wada, T., Bouchard, D., Hwang, I., Takeda, K., Fujita, T., Der, S., Penninger, J.M., Akira, S., Saito, T., Yeh, W.C. J. Immunol. (2003)
- Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein. Hatao, F., Muroi, M., Hiki, N., Ogawa, T., Mimura, Y., Kaminishi, M., Tanamoto, K. J. Leukoc. Biol. (2004)
- A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Suzuki, N., Suzuki, S., Millar, D.G., Unno, M., Hara, H., Calzascia, T., Yamasaki, S., Yokosuka, T., Chen, N.J., Elford, A.R., Suzuki, J., Takeuchi, A., Mirtsos, C., Bouchard, D., Ohashi, P.S., Yeh, W.C., Saito, T. Science (2006)
- Metal ion-mediated reduction in surface entropy improves diffraction quality of crystals of the IRAK-4 death domain. Lasker, M.V., Kuruvilla, S.M., Gajjar, M.M., Kapoor, A., Nair, S.K. Journal of biomolecular techniques : JBT. (2006)
- Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70. Mun, H.S., Aosai, F., Norose, K., Piao, L.X., Fang, H., Akira, S., Yano, A. Infect. Immun. (2005)