The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tlr1  -  toll-like receptor 1

Mus musculus

Synonyms: TIL, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tlr1


High impact information on Tlr1


Chemical compound and disease context of Tlr1


Biological context of Tlr1


Anatomical context of Tlr1

  • These results indicate that mRNAs for Tlr1 through Tlr6 are expressed by uterine epithelial cells and that treatment with specific TLR agonists alters the expression of key chemokines and proinflammatory cytokines that contribute to the defense of the uterus against potential pathogens [18].
  • Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice [19].
  • Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering [20].
  • Results of a previous study indicated that cell-wall components of pneumococci are recognized by Toll-like receptor (TLR)2 but suggested that pneumolysin induces inflammatory events independently of this receptor [21].
  • In this study, we demonstrate that different Toll-like receptor (TLR) ligands induce distinct dendritic cell (DC) activation and immune responses in vivo [22].

Associations of Tlr1 with chemical compounds


Regulatory relationships of Tlr1


Other interactions of Tlr1


Analytical, diagnostic and therapeutic context of Tlr1


  1. The expression of toll-like receptor 2 and 4 mRNA in local tissues of model of oropharyngeal candidiasis in mice. Zhang, S., Li, J., Jia, X., Wu, Y. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2004) [Pubmed]
  2. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G.D., Mascarenhas, M.M., Garg, H.G., Quinn, D.A., Homer, R.J., Goldstein, D.R., Bucala, R., Lee, P.J., Medzhitov, R., Noble, P.W. Nat. Med. (2005) [Pubmed]
  3. Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs. Tötemeyer, S., Kaiser, P., Maskell, D.J., Bryant, C.E. Infect. Immun. (2005) [Pubmed]
  4. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. Park, J.M., Ng, V.H., Maeda, S., Rest, R.F., Karin, M. J. Exp. Med. (2004) [Pubmed]
  5. Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guerin and mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response. Gilleron, M., Quesniaux, V.F., Puzo, G. J. Biol. Chem. (2003) [Pubmed]
  6. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Lang, K.S., Recher, M., Junt, T., Navarini, A.A., Harris, N.L., Freigang, S., Odermatt, B., Conrad, C., Ittner, L.M., Bauer, S., Luther, S.A., Uematsu, S., Akira, S., Hengartner, H., Zinkernagel, R.M. Nat. Med. (2005) [Pubmed]
  7. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Leadbetter, E.A., Rifkin, I.R., Hohlbaum, A.M., Beaudette, B.C., Shlomchik, M.J., Marshak-Rothstein, A. Nature (2002) [Pubmed]
  8. IkappaBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Kuwata, H., Matsumoto, M., Atarashi, K., Morishita, H., Hirotani, T., Koga, R., Takeda, K. Immunity (2006) [Pubmed]
  9. TRAIL-R as a negative regulator of innate immune cell responses. Diehl, G.E., Yue, H.H., Hsieh, K., Kuang, A.A., Ho, M., Morici, L.A., Lenz, L.L., Cado, D., Riley, L.W., Winoto, A. Immunity (2004) [Pubmed]
  10. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Kinjyo, I., Hanada, T., Inagaki-Ohara, K., Mori, H., Aki, D., Ohishi, M., Yoshida, H., Kubo, M., Yoshimura, A. Immunity (2002) [Pubmed]
  11. Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis. van Westerloo, D.J., Weijer, S., Bruno, M.J., de Vos, A.F., Van't Veer, C., van der Poll, T. Crit. Care Med. (2005) [Pubmed]
  12. Correlation between chemical structure and biological activities of Porphyromonas gingivalis synthetic lipopeptide derivatives. Makimura, Y., Asai, Y., Taiji, Y., Sugiyama, A., Tamai, R., Ogawa, T. Clin. Exp. Immunol. (2006) [Pubmed]
  13. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. Joosten, L.A., Koenders, M.I., Smeets, R.L., Heuvelmans-Jacobs, M., Helsen, M.M., Takeda, K., Akira, S., Lubberts, E., van de Loo, F.A., van den Berg, W.B. J. Immunol. (2003) [Pubmed]
  14. BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. Liu, Y., Dong, W., Chen, L., Xiang, R., Xiao, H., De, G., Wang, Z., Qi, Y. J. Biol. Chem. (2004) [Pubmed]
  15. An essential role of the NF-kappa B/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. Li, M., Carpio, D.F., Zheng, Y., Bruzzo, P., Singh, V., Ouaaz, F., Medzhitov, R.M., Beg, A.A. J. Immunol. (2001) [Pubmed]
  16. Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway. Ogawa, T., Asai, Y., Hashimoto, M., Takeuchi, O., Kurita, T., Yoshikai, Y., Miyake, K., Akira, S. Int. Immunol. (2002) [Pubmed]
  17. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Shibata, Y., Berclaz, P.Y., Chroneos, Z.C., Yoshida, M., Whitsett, J.A., Trapnell, B.C. Immunity (2001) [Pubmed]
  18. Expression of Toll-like receptors (TLR) and responsiveness to TLR agonists by polarized mouse uterine epithelial cells in culture. Soboll, G., Shen, L., Wira, C.R. Biol. Reprod. (2006) [Pubmed]
  19. Toll-like Receptor 7-Dependent Loss of B Cell Tolerance in Pathogenic Autoantibody Knockin Mice. Berland, R., Fernandez, L., Kari, E., Han, J.H., Lomakin, I., Akira, S., Wortis, H.H., Kearney, J.F., Ucci, A.A., Imanishi-Kari, T. Immunity (2006) [Pubmed]
  20. Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering. Myers, L., Takahashi, C., Mittler, R.S., Rossi, R.J., Vella, A.T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  21. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Malley, R., Henneke, P., Morse, S.C., Cieslewicz, M.J., Lipsitch, M., Thompson, C.M., Kurt-Jones, E., Paton, J.C., Wessels, M.R., Golenbock, D.T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  22. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. Dillon, S., Agrawal, A., Van Dyke, T., Landreth, G., McCauley, L., Koh, A., Maliszewski, C., Akira, S., Pulendran, B. J. Immunol. (2004) [Pubmed]
  23. Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells. Hornef, M.W., Normark, B.H., Vandewalle, A., Normark, S. J. Exp. Med. (2003) [Pubmed]
  24. Can medroxyprogesterone acetate alter Toll-like receptor expression in a mouse model of intrauterine inflammation? Elovitz, M.A., Mrinalini, C. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  25. Toll-like receptor ligands reverse suppression of contact hypersensitivity reactions induced by epicutaneous immunization with protein antigen. Ptak, W., Bryniarski, K., Ptak, M., Majewska, M., Gamian, A., Lobo, F.M., Szczepanik, M. Int. Arch. Allergy Immunol. (2006) [Pubmed]
  26. Carbon monoxide increases macrophage bacterial clearance through Toll-like receptor (TLR)4 expression. Otterbein, L.E., May, A., Chin, B.Y. Cell. Mol. Biol. (Noisy-le-grand) (2005) [Pubmed]
  27. Genetic dissection of innate immunity to infection: the mouse cytomegalovirus model. Beutler, B., Crozat, K., Koziol, J.A., Georgel, P. Curr. Opin. Immunol. (2005) [Pubmed]
  28. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Gilchrist, M., Thorsson, V., Li, B., Rust, A.G., Korb, M., Kennedy, K., Hai, T., Bolouri, H., Aderem, A. Nature (2006) [Pubmed]
  29. JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. Matsuguchi, T., Masuda, A., Sugimoto, K., Nagai, Y., Yoshikai, Y. EMBO J. (2003) [Pubmed]
  30. A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. Sugimoto, K., Ohata, M., Miyoshi, J., Ishizaki, H., Tsuboi, N., Masuda, A., Yoshikai, Y., Takamoto, M., Sugane, K., Matsuo, S., Shimada, Y., Matsuguchi, T. J. Clin. Invest. (2004) [Pubmed]
  31. Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS. Honma, K., Udono, H., Kohno, T., Yamamoto, K., Ogawa, A., Takemori, T., Kumatori, A., Suzuki, S., Matsuyama, T., Yui, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  32. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. Gingras, S., Parganas, E., de Pauw, A., Ihle, J.N., Murray, P.J. J. Biol. Chem. (2004) [Pubmed]
  33. Regulation of Toll-like receptor 4 expression in mouse colon by macrophage migration inhibitory factor. Ohkawara, T., Takeda, H., Miyashita, K., Nishiwaki, M., Nakayama, T., Taniguchi, M., Yoshiki, T., Takana, J., Imamura, M., Sugiyama, T., Asaka, M., Nishihira, J. Histochem. Cell Biol. (2006) [Pubmed]
  34. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Subramanian, S., Tus, K., Li, Q.Z., Wang, A., Tian, X.H., Zhou, J., Liang, C., Bartov, G., McDaniel, L.D., Zhou, X.J., Schultz, R.A., Wakeland, E.K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  35. Effect of Chlamydia pneumoniae on cellular ATP content in mouse macrophages: role of Toll-like receptor 2. Yaraei, K., Campbell, L.A., Zhu, X., Liles, W.C., Kuo, C.C., Rosenfeld, M.E. Infect. Immun. (2005) [Pubmed]
  36. Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Shen, X.D., Ke, B., Zhai, Y., Gao, F., Busuttil, R.W., Cheng, G., Kupiec-Weglinski, J.W. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2005) [Pubmed]
  37. Toll-like receptor 4 mutation impairs the macrophage TNFalpha response to peptidoglycan. Li, Q., Cherayil, B.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  38. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation. Wolfs, T.G., Buurman, W.A., van Schadewijk, A., de Vries, B., Daemen, M.A., Hiemstra, P.S., van 't Veer, C. J. Immunol. (2002) [Pubmed]
  39. Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS. Lee, E.K., Kang, S.M., Paik, D.J., Kim, J.M., Youn, J. Int. Immunol. (2005) [Pubmed]
  40. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. Goldstein, D.R., Tesar, B.M., Akira, S., Lakkis, F.G. J. Clin. Invest. (2003) [Pubmed]
  41. Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Warger, T., Osterloh, P., Rechtsteiner, G., Fassbender, M., Heib, V., Schmid, B., Schmitt, E., Schild, H., Radsak, M.P. Blood (2006) [Pubmed]
  42. MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS. Koedel, U., Rupprecht, T., Angele, B., Heesemann, J., Wagner, H., Pfister, H.W., Kirschning, C.J. Brain (2004) [Pubmed]
WikiGenes - Universities