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Gene Review

GGT5  -  gamma-glutamyltransferase 5

Homo sapiens

Synonyms: GGL, GGT 5, GGT-REL, GGT-rel, GGTLA1, ...
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High impact information on GGTLA1

  • The genes in the repeat are GGT, BCRL, V7-rel, POM121-like, and GGT-rel [1].
  • The deduced amino acid sequence of this cDNA, GGT-rel, exhibited an overall similarity of 39.5% with human GGT [2].
  • Experiments with glutathione added to the medium suggested that GGT-rel could hydrolyze the gamma-glutamyl moiety [2].
  • The present study demonstrates for the first time that an established cell line expressing GGT-rel, a human GGT-related enzyme, metabolizes extracellular GSH to cysteinylglycine (CysGly) in a time-dependent manner when cells were incubated in a medium containing 2.5 mM GSH and 25 mM glycylglycine [3].
  • A higher iron reduction and an increased LPO level determined by malondialdehyde HPLC measurement were also found in GGT-rel-overexpressing cells compared to GGT-rel negative cells [3].

Biological context of GGTLA1


Other interactions of GGTLA1


  1. Low-copy repeats mediate the common 3-Mb deletion in patients with velo-cardio-facial syndrome. Edelmann, L., Pandita, R.K., Morrow, B.E. Am. J. Hum. Genet. (1999) [Pubmed]
  2. Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. Heisterkamp, N., Rajpert-De Meyts, E., Uribe, L., Forman, H.J., Groffen, J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme. Enoiu, M., Aberkane, H., Salazar, J.F., Leroy, P., Groffen, J., Siest, G., Wellman, M. Free Radic. Biol. Med. (2000) [Pubmed]
  4. Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22. Morris, C., Courtay, C., Geurts van Kessel, A., ten Hoeve, J., Heisterkamp, N., Groffen, J. Hum. Genet. (1993) [Pubmed]
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