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Gene Review

Ggt5  -  gamma-glutamyltransferase 5

Mus musculus

Synonyms: AI551243, GGL, GGT 5, GGT-REL, Gamma-glutamyl leukotrienase, ...
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Disease relevance of Ggtla1


High impact information on Ggtla1


Biological context of Ggtla1

  • Mapping of the GGL transcription start site revealed that the GGL promoter is TATA-less but contains an initiator, a control element for transcription initiation [3].

Anatomical context of Ggtla1


Associations of Ggtla1 with chemical compounds


Other interactions of Ggtla1

  • Here we show that in vivo GGL, and not GGT as previously believed, is primarily responsible for conversion of leukotriene C(4) to leukotriene D(4), the most potent of the cysteinyl leukotrienes and the immediate precursor of leukotriene E(4) [2].

Analytical, diagnostic and therapeutic context of Ggtla1

  • In contrast to wild-type and GGT-deficient mice, GGL-deficient mice do not form leukotriene D(4) in vivo either in blood when exogenous leukotriene C(4) is administered intravenously or in bronchoalveolar lavage fluid of Aspergillus fumigatus extract-induced experimental asthma [2].
  • Northern blots for GGL expression were negative [3].
  • As judged by ribonuclease protection, in situ hybridization, and measurement of enzyme activity, spleen had the highest level of GGL expression [3].


  1. Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. Shi, Z.Z., Han, B., Habib, G.M., Matzuk, M.M., Lieberman, M.W. Mol. Cell. Biol. (2001) [Pubmed]
  2. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Han, B., Luo, G., Shi, Z.Z., Barrios, R., Atwood, D., Liu, W., Habib, G.M., Sifers, R.N., Corry, D.B., Lieberman, M.W. Am. J. Pathol. (2002) [Pubmed]
  3. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. Carter, B.Z., Shi, Z.Z., Barrios, R., Lieberman, M.W. J. Biol. Chem. (1998) [Pubmed]
  4. Gamma-glutamyl leukotrienase cleavage of leukotriene C4. Lieberman, M.W., Shields, J.E., Will, Y., Reed, D.J., Carter, B.Z. Adv. Exp. Med. Biol. (1999) [Pubmed]
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