Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Ggt5 - gamma-glutamyltransferase 5

Rattus norvegicus

Synonyms: GGL, GGT 5, GGT-rel, Gamma-glutamyl leukotrienase, Gamma-glutamyl transpeptidase-related enzyme, ...

Potdar, P.D. et al., Petrescu, I. et al.

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High impact information on Ggtla1

GGT-rel was weakly expressed in normal trachea but was strongly induced by epidermal growth factor in cultures of RTE cells [1].
GGT-rel was also highly expressed in lung tumors induced by inhalation of isobutyl nitrite [1].
The induction of high levels of GGT-rel may play an important role in protecting the lung from oxidative stress or other toxic insults [1].
Glutathione plays an essential role in protecting the pulmonary system from toxic insults. gamma-Glutamyl transpeptidase-related enzyme (GGT-rel) is a novel protein capable of cleaving the gamma-glutamyl peptide bond of glutathione and of converting leukotriene C4 to leukotriene D4 [1].
Infusion of diclofenac (0.1 mM) or aspirin (5 mM) strongly stimulated glycogenolysis and glycolysis (GGL/GL) [2].

Other interactions of Ggtla1

These results demonstrate that GGT-rel 1) is expressed in normal tracheal cells, 2) can be induced by epidermal growth factor, and 3) is elevated after chemical exposure [1].

References

Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells. Potdar, P.D., Andrews, K.L., Nettesheim, P., Ostrowski, L.E. Am. J. Physiol. (1997) [Pubmed]
Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat. Petrescu, I., Tarba, C. Biochim. Biophys. Acta (1997) [Pubmed]

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